Relaxin: A Magical Therapy for Healthy Heart

Abstract

Relaxin (a peptide hormone) has emerged as a cardio protective agent and plays a vital role in normal cardiac function. By activation a complex network of signalling cascade, relaxin is responsible for creating a healthy environment for heart functioning. Under pathological conditions, such as cardiomyopathy and heart failure, the expression level of relaxin is increased dramatically to protect the heart. By promoting angiogenesis, vasodilatation, improving ischemia/reperfusion injury and remodeling, relaxin has emerged as a magical agent to address cardiac abnormalities. Over the past 3 decades, various cardio protection strategies are in use to deal with cardiac diseases, however, till date, no effective therapy is in clinical practice. Relaxin has emerged as a novel therapeutic agent to have beneficial action during various pathological conditions. In this review, we have discussed different cardio protective roles of relaxin that marks it, as an effective agent to tackle heart-related diseases.

Relaxin inhibits 177Lu-EDTMP associated cell death in osteosarcoma cells through notch-1 pathway

“…were unearthed (8)(9)(10)(11). Humans express three types of relaxins (relaxin 1, relaxin 2, and relaxin 3), and each performs a unique role (12,13). It has been reported that relaxin 2 (RLXH2) gets overexpressed in different cancers and aids in cell proliferation, metastasis and invasiveness (14,15).…”