Release Adjustment of Two Drugs with Different Solubility Combined in a Matrix Tablet

Chaerunisaa, Anis Yohana; Ali, Rebaz; Dashevskiy, Andriy

doi:10.1208/s12249-019-1294-2

Cited by 8 publications

(5 citation statements)

References 27 publications

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“…The main mechanisms for water-soluble and water-insoluble drugs are diffusion and erosion, respectively. 15) The dissolution results clarified differences in the dissolution behaviors of the APIs and water-soluble polymers from the three model tablets.…”

Section: Discussionmentioning

confidence: 89%

“…The dissolution of base excipients, in addition to APIs, is important information for the development of SRFs, especially those prepared from water-soluble polymer matrices. However, few studies have reported the dissolution of the polymer excipients, [14][15][16] because conventional analytical methods are usually labor-intensive and time-consuming. With an appropriate analytical method, much information can be made available concerning the dissolution behaviors of APIs and polymers to aid formulation design.…”

Section: Discussionmentioning

confidence: 99%

“…14) Utilizing gravimetry, Chaerunisaa et al reported a modification to the release of two APIs with different solubilities in a combined matrix tablet as a fixed-dose combination for extended release. 15) In gravimetry, tablets must be removed from the dissolution test machine, resulting in the termination of the dissolution test. Additionally, it takes considerable time to dry wet tablets.…”

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Simultaneous Determination of Active Pharmaceutical Ingredients and Water-Soluble Polymers: Analysis of Dissolution Profiles from Sustained-Release Formulations and Mechanisms Involved

Kimoto

Sakane

Katsumi

et al. 2022

CHEMICAL & PHARMACEUTICAL BULLETIN

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The dissolution behaviors of base excipients from sustained-release formulations have been investigated using various methodologies. However, the dissolution of polymers has not been fully evaluated because differences between formulations are still verified only by the release of active pharmaceutical ingredients (APIs). In our previous study, we proposed a quick and simultaneous analysis of dissolved APIs and watersoluble polymers by ultra HPLC using charged aerosol and photodiode array detectors. The purpose of this study was to verify whether the analysis system could be adapted to other water-soluble polymers. Dissolution tests were conducted using matrix model tablets prepared from three polymers and three APIs (propranolol, ranitidine, and cilostazol) with different solubilities. The dissolution profiles of the polymers and APIs were determined using the proposed analysis system and compared. The results clarified differences in the dissolution behaviors of the APIs and polymers. The polymers, especially hydroxypropyl cellulose, exhibited the dissolution properties characteristic of each model formulation. Propranolol and ranitidine showed the diffusion type, while cilostazol showed the erosion type release mechanism due to their different solubilities. The release of cilostazol was delayed in all models compared to the polymer, which may be due to the aggregation of cilostazol in the gel layer. This analytical method can be used to study the dissolution behavior (diffusion or erosion) of APIs from matrix tablets containing various polymers. This method will provide useful information on release control, which will make it easier and more efficient to design appropriate formulations and analyze the release mechanisms.

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Section: Discussionmentioning

confidence: 89%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Simultaneous Determination of Active Pharmaceutical Ingredients and Water-Soluble Polymers: Analysis of Dissolution Profiles from Sustained-Release Formulations and Mechanisms Involved

Kimoto

Sakane

Katsumi

et al. 2022

CHEMICAL & PHARMACEUTICAL BULLETIN

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“…Indeed, the mucoadhesive polymers used for developing the patches have been widely referred to and used by formulation scientists due to their affordability, drug release versatility, attractive mechanical properties, and biocompatibility. [41][42][43][44] In our team's preliminary studies, 22 we obtained great advances with local anesthesia by determining the onset and duration of anesthesia following the administration of a monolayer (drug release) in volunteers. However, the first prototype was rectangular and its edges were not delimited by the mucoadhesive and backing layers used herein.…”

Section: Discussionmentioning

confidence: 99%

Needle-free anesthesia: clinical efficacy of a mucoadhesive patch for atraumatic anesthesia in dental procedures

et al. 2021

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“…The methocel ® is white or off white powder [13]. It is inert and gives good control through gel formation and erosion [14]. Physical structures of HPMC hydrogels (a1, b1 at lower temperatures and a2, b2 at higher temperatures) [16] These polymers can control the release of the active pharmaceutical ingredient [17,18].…”

Section: Introductionmentioning

confidence: 99%

Estimation of Quality Characteristics for Sustained Releasing and Acting Formulation of Domperidone

Zeb-un-Nisa¹,

Ali²,

Shahnaz³

et al. 2021

Pharmacophore

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The present study aimed to design a sustained releasing and acting formulation of Domperidone with the aid of hydrophilic Methocel® K4M. Domperidone is an antiemetic drug used to treat nausea and vomiting. Generally, the dosing frequency is twice or thrice daily. Sustained-release formulation was prepared with different ratios of K4M. Furthermore, its quality and stability were determined. Pre-compression and post-compression characteristics were examined and the optimized formulation was selected for dissolution studies and also for similarity profiles. Drug dissolution studies revealed formulated tablet containing CF2 depicted the ideal release profile for once-daily consumption. Long-acting domperidone matrices were not just prepared but also displayed desirable properties required for an ideal once-daily formulation. The mechanism might be gel layer formation which afterward proceeded by gel erosion, hence giving a long slowreleasing pattern and desirable therapeutic effect. The concept of controlled release formulations helps the patients and care givers by reducing dosing frequency and chances of missed doses or overnight gap in administration of dose.

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Release Adjustment of Two Drugs with Different Solubility Combined in a Matrix Tablet

Cited by 8 publications

References 27 publications

Simultaneous Determination of Active Pharmaceutical Ingredients and Water-Soluble Polymers: Analysis of Dissolution Profiles from Sustained-Release Formulations and Mechanisms Involved

Simultaneous Determination of Active Pharmaceutical Ingredients and Water-Soluble Polymers: Analysis of Dissolution Profiles from Sustained-Release Formulations and Mechanisms Involved

Needle-free anesthesia: clinical efficacy of a mucoadhesive patch for atraumatic anesthesia in dental procedures

Estimation of Quality Characteristics for Sustained Releasing and Acting Formulation of Domperidone

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