Release behaviour and biocompatibility of drug-loaded pH sensitive particles

Sipahigil, Oya; Gürsoy, Aylâ; Çakalağaoğlu, Fulya; Okar, İmer

doi:10.1016/j.ijpharm.2005.12.024

Cited by 19 publications

(17 citation statements)

References 17 publications

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“…Chitosan (Chi), an N-deacetylated derivative of chitin and a naturally occurring biopolymer with minimal toxicity that exhibits mucoadhesive properties, was identified as a potential component to increase GI transit time of the vitamin and consequently its bioavailability. Various formulations of Chi particles have been studied to promote sustained release of both hydrophilic [19][20][21] and hydrophobic [22,23] drugs, to increase mucoadhesion [24][25][26], for drug targeting [27] and pH-sensitive drug delivery [19,28], DNA transfection [29][30][31], protein protection and delivery [32][33][34][35], increased absorption and uptake [36,37], as well as for vaccination [38][39][40][41][42][43]. Chi-based particles were also used to delay gastric emptying [44,45].…”

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confidence: 99%

Chitosan/PLGA Particles for Controlled Release of α-Tocopherol in The GI Tract Via Oral Administration

et al. 2011

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confidence: 99%

Chitosan/PLGA Particles for Controlled Release of α-Tocopherol in The GI Tract Via Oral Administration

et al. 2011

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“…Chitosan exhibits unique functional, nutritional, and biomedical properties (Remuńår-López et al, 1998;Kim et al, 2003;Torre et al, 2003). Chitosan has been used for many biomedical and pharmaceutical applications to improve drug delivery as well as for controlled delivery (Sanil et al, 2007;Sipahigil et al, 2006). In the case of drug delivery applications, chitosan has been employed for preparation of drug-loaded microcapsules/ microspheres and used to provide controlled drug release and improve bioavailability of drugs (Lee et al, 1996).…”

Section: Introductionmentioning

confidence: 99%

“…Polyelectrolyte complex (PEC) in the form of beads or microspheres formed by cationic polymer(s) and anionic polymer(s) could further enhance the controlled or prolonged release of the drug. Examples of PEC for controlling drug release include alginate/chitosan (Parfitt, Marindale, 1996), chitosan-cellulose multicore microparticles (Sanil et al,2007), chitosan-coated pectin (Sipahigil et al, 2006), chitosan/poly(acrylic acid) complexes (Sezer, Akbuga, 1999), poly(vinylalcohol)/sodium alginate blend beads (Gonzålez-Rodriguez et al, 2002), and poly(methacrylic acid-g-ethylene glycol) particles (Lee et al, 1996). The non-steroidal anti-inflammatory drug, sodium diclofenac is a good candidate for the development of oral sustained release formulations.…”

Section: Introductionmentioning

confidence: 99%

Effect of cross-linked biodegradable polymers on sustained release of sodium diclofenac-loaded microspheres

Saha¹,

Ray²

2013

Braz. J. Pharm. Sci.

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The objective of this study was to formulate an oral sustained release delivery system of sodium diclofenac(DS) based on sodium alginate (SA) as a hydrophilic carrier in combination with chitosan (CH) and sodium carboxymethyl cellulose (SCMC) as drug release modifiers to overcome the drug-related adverse effects and to improve bioavailability. Microspheres of DS were prepared using an easy method of ionotropic gelation. The prepared beads were evaluated for mean particle size, entrapment efficiency, swelling capacity, erosion and in-vitro drug release. They were also subjected to various studies such as Fourier Transform Infra-Red Spectroscopy (FTIR) for drug polymer compatibility, Scanning Electron Microscopy for surface morphology, X-ray Powder Diffraction Analysis (XRD) and Differential Scanning Calorimetric Analysis (DSC) to determine the physical state of the drug in the beads. The addition of SCMC during the preparation of polymeric beads resulted in lower drug loading and prolonged release of the DS. The release profile of batches F5 and F6 showed a maximum drug release of 96.97 ± 0.356% after 8 h, in which drug polymer ratio was decreased. The microspheres of sodium diclofenac with the polymers were formulated successfully. Analysis of the release profiles showed that the data corresponds to the diffusion-controlled mechanism as suggested by Higuchi.Uniterms: Alginate beads/preparation. Alginate beads/evaluation. Drugs/sustained release. Interpenetrating network. Sodium diclofenac/microsphere/sustained release. Ionotropic gelation.

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“…Examples of PECs for controlling drug release include alginate/CS (3,4), CS/carrageenan (5), CS-cellulose multicore microparticles (6), CS-coated pectin (7), CS/poly(acrylic acid) complexes (8), poly(vinyl alcohol)/sodium alginate blend beads (9), and poly(methacrylic acid-g-ethylene glycol) particles (10).…”

Section: Introductionmentioning

confidence: 99%

Chitosan/Polyethylene Glycol Beads Crosslinked with Tripolyphosphate and Glutaraldehyde for Gastrointestinal Drug Delivery

2010

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Abstract. This study reports on the preparation of chitosan (CS)/polyethylene glycol (PEG) hydrogel beads using sodium diclofenac (DFNa) as a model drug. Following the optimization of the polymer to drug ratio, the chitosan beads were modified by ionic crosslinking with sodium tripolyphosphate (TPP). The CS/PEG/DFNa beads obtained from a (w/w/w) ratio of 1/0.5/0.5 with crosslinking in 10% (w/v) TPP at pH 6.0 for 30 min yielded excellent DFNa encapsulation levels with over 90% loading efficiency. The dissolution profile of DFNa from CS/PEG/DFNa beads demonstrated that this formulation was able to maintain a prolonged drug release for approximately 8 h. Among the formulations tested, the CS/PEG/ DFNa (1/0.5/1 (w/w/w)) beads crosslinked with a combination of TPP (10% (w/v) for 30 min) and glutaraldehyde (GD) (5% (w/v)) were able to provide minimal DFNa release in the gastric and duodenal simulated fluids (pH 1.2 and 6.8, respectively) allowing for a principally gradual drug release over 24 h in the intestinal (jejunum and ileum) simulated fluid (pH 7.4). Thus, overall the CS/PEG beads crosslinked with TPP and GD look to be a promising and novel alternative gastrointestinal drug release system.

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Release behaviour and biocompatibility of drug-loaded pH sensitive particles

Cited by 19 publications

References 17 publications

Chitosan/PLGA Particles for Controlled Release of α-Tocopherol in The GI Tract Via Oral Administration

Chitosan/PLGA Particles for Controlled Release of α-Tocopherol in The GI Tract Via Oral Administration

Effect of cross-linked biodegradable polymers on sustained release of sodium diclofenac-loaded microspheres

Chitosan/Polyethylene Glycol Beads Crosslinked with Tripolyphosphate and Glutaraldehyde for Gastrointestinal Drug Delivery

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