Release kinetic study of RHPC coated aspirin microcapsules

Abstract

The present communication deals with the study of the effect of pH on the drug release characteristics and the drug release kinetic from the RHPC (Rosin Hard Paraffin Combination) coated aspirin microcapsules. For the purpose of the present study the aspirin microcapsules were prepared by pan coating method imparting 15 coats using 10 per cent RHPC solution in acetone. A standard coating procedure was used to coat the aspirin granules. Dissolution studies were carried out in media with different pH. To get a clear picture drug release studies were conducted in each media for 3 h. The results showed that the RHPC films were resistant to acidic pH releasing less than 5 per cent and 15 per cent drug in 3 h in pH 1.2 and 3.0 respectively. The T 50% in pH 5.0 media was 163 min. The drug was released very quickly in pH 7.2 and 8.0. The release kinetic study showed that the release followed the classical first order pattern though the coated microcapsules used to be intact during the dissolution process, in case of the acidic pH media. The release kinetic was changed when the pH of the dissolution media was 7.2 and above. It was found that during the dissolution process the granules undergo erosion and the release mechanism does not follow a single process.

Forest Products with Health-Promoting and Medicinal Properties

“…It is a brittle, transparent, glassy solid produced by heating fresh liquid resin to vaporize the volatile liquid terpene components. Rosin and rosin derivatives have been pharmaceutically evaluated as microencapsulating materials and as anhydrous binding agents in tablets (Fulzele et al 2002(Fulzele et al , 2007Pathak and Dorle 1990;Sahu et al 1999;Satturwar et al 2004;Lee et al 2005). Rosin biomaterias have excellent biocompatibility and degradation features, and film-forming ability (Fulzele et al 2003).…”

Polyethylene-Starch Extrudates as Erodible Carriers for Bioactive Materials: I. Erodibility and in vitro Dye Release Studies

“…Early application of these types of drug delivery systems was in the field of contraception; since then, many reports have been published concerning long-term release of several drugs [1][2][3][4] and different drug delivery systems [5][6][7][8][9].…”