Release kinetics of 5-aminosalicylic acid from halloysite

Aguzzi, Carola; Viseras, César; Cerezo, Pilar; Salcedo, I.; Sánchez-Espejo, Rita; Valenzuela, Carolina

doi:10.1016/j.colsurfb.2012.12.041

Cited by 67 publications

(40 citation statements)

References 46 publications

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“…Controlled loading and sustained release of 5-aminosalycilic acid into HNT was proved (Aguzzi et al, 2013). The introduction of 5-aminosalycilic acid/HNT within the thermoplastic starch generates a biopolymer that can transport the drug through the acidic medium of the stomach and that can release it in sustained manner in the colon.…”

Section: Applications Of Hnt/polysaccharide Nanocompositesmentioning

confidence: 99%

Halloysite ‐Based Bionanocomposites

Lazzara

Massaro

Milioto

et al. 2017

Handbook of Composites From Renewable Materials

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Scientific research has been invigorated by a new class of biodegradable materials as alternatives to polymers derived from fossils. Such biomaterials can also offer economic advantages because they are derived from renewable resources. Several biopolymers (gelatin, chitin, chitosan, starch, pectin, cellulose and its modified versions, etc.) have been exploited to produce films and formulations. Their use is limited because of fast degradation, predominant hydrophilic character, and, in some cases, unsatisfactory mechanical properties. However, the properties of these polymers can be improved by using inorganic fillers such as additives. Halloysite nanotube is a promising green filler for this purpose.

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Section: Applications Of Hnt/polysaccharide Nanocompositesmentioning

confidence: 99%

Halloysite ‐Based Bionanocomposites

Lazzara

Massaro

Milioto

et al. 2017

Handbook of Composites From Renewable Materials

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“…We suggest that the high affinity site corresponds to the surface of the inner lumen, which is expected to bind the mildly acidic quercetin through strong H-bonding and Coulombic interactions, from which it is slowly released following solid-liquid reversible adsorption-desorption kinetics. 53 The intermediate affinity L 2 site corresponds to the solid drug accumulated in the hollow space inside HNTs, which is not easily reached by solvents, whereas the fast release site L 1 corresponds to the quercetin absorbed at the ends of HNTs, as depicted in Fig. 9.…”

Section: Hnt/que Nanotubesmentioning

confidence: 99%

A synergic nanoantioxidant based on covalently modified halloysite–trolox nanotubes with intra-lumen loaded quercetin

et al. 2016

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We describe the preparation and properties of the first example of a synergic nanoantioxidant, obtained by different functionalizations of the external surface and the inner lumen of halloysite nanotubes (HNTs). Trolox, a mimic of natural a-tocopherol, was selectively grafted on the HNT external surface; while quercetin, a natural polyphenolic antioxidant, was loaded into the inner lumen to afford a bi-functional nanoantioxidant, HNT-Trolox/Que, which was investigated for its reactivity with transient Synergism between the distinct antioxidant functions was based on the rapid reaction of externally exposed Trolox (rate constant with peroxyl radicals was 1.1 Â 10 6 M À1 s À1 and 9 Â 10 4 M À1 s À1respectively in chlorobenzene and acetonitrile, at 30 1C), followed by its regeneration by quercetin released from the HNT lumen. The advantages of this novel nanoantioxidant are discussed.

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“…Each study performed highlighted that although halloysite can be easily taken up by the cultured cells, accumulating predominantly near its perinuclear region, its toxicity was reported to be very low. 22 brilliant green, 23 salicylic acid 24 and so on, 25,26 which all focused on its inherent lumen. Recently Zhou et al reported a dual-DDS comprising poly(L-lactide)/HNTs electrospun mats capable of co-delivering hydrophilic and hydrophobic drugs.…”

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confidence: 99%

Dual drug-loaded halloysite hybrid-based glycocluster for sustained release of hydrophobic molecules

et al. 2016

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A dual drug-loaded HNT-CD glycocluster delivery system based on halloysite nanotubes and carbohydrate functionalized cyclodextrin was developed by a green protocol using solvent-free microwave irradiation.The nanohybrid was employed for concurrent load and release of silibinin and curcumin. The new delivery system was characterized by means of TGA, FT-IR spectroscopy, SEM and DLS. These techniques confirm the successful loading of the two drugs in the system. SEM and DLS measurements highlighted that the nanomaterial preserves a tubular structure with an average hydrodynamic radius of ca. 200 nm. The release of the drugs from the HNT glycocluster was investigated by means of UV-vis spectroscopy at two different pH values simulanting the typical physiological conditions of either gastric or intestinal fluids.Enzyme-linked lectin assays (ELLA) demonstrated that highly mannoside-cyclodextrins HNT entities display high affinity towards mannose selective ConA lectin. Biological assays showed that the new drug delivery system exhibits anti-proliferative activity against the investigated cell lines. Fluorescence microscopy confirmed ELLA results and it showed a high propensity of this drug delivery system to cross cell membranes and to penetrate into the cell nucleus. The results revealed that the synthesized multicavity system is a material of suitable size and nanoarchitecture to transport drugs into living cells.

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Release kinetics of 5-aminosalicylic acid from halloysite

Cited by 67 publications

References 46 publications

Halloysite ‐Based Bionanocomposites

Halloysite ‐Based Bionanocomposites

A synergic nanoantioxidant based on covalently modified halloysite–trolox nanotubes with intra-lumen loaded quercetin

Dual drug-loaded halloysite hybrid-based glycocluster for sustained release of hydrophobic molecules

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