Release Kinetics of Cardiac Biomarkers in Patients Undergoing Transcoronary Ablation of Septal Hypertrophy

Liebetrau, Christoph; Möllmann, Helge; Nef, Holger; Szardien, Sebastian; Rixe, Johannes; Troidl, Christian; Willmer, Matthias; Hoffmann, Jedrzej; Weber, Michael; Rolf, Andreas; Hamm, Christian W.

doi:10.1373/clinchem.2011.178129

Cited by 40 publications

(33 citation statements)

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“…The presence of pregnancyassociated, placenta-specific microRNAs (miRNAs) 1 in the plasma of pregnant women has recently been reported (1 ). Such miRNAs have potential as molecular markers for complete hydatidiform mole (CHM), which is usually diploid and androgenetic in origin.…”

Section: To the Editormentioning

confidence: 99%

“…There were no significant differences between the CHM and control groups in maternal age or gestational age (data not shown). Preparation and extraction of total RNA containing small RNA molecules from tissue samples or from 1.2-mL samples of cell-free plasma, as well as absolute RT-qPCR analysis, were performed as described previously (1,2 ). The intraassay CVs for hsamiR-520b, -miR-520f, and -520c-3p) in the absolute RT-qPCR assays were 8.1%, 6.4%, and 6.8%, respectively.…”

Section: To the Editormentioning

confidence: 99%

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Ninety-Minute vs 3-h Performance of High-Sensitivity Cardiac Troponin Assays for Predicting Hospitalization for Acute Coronary Syndrome

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Section: To the Editormentioning

confidence: 99%

Section: To the Editormentioning

confidence: 99%

Ninety-Minute vs 3-h Performance of High-Sensitivity Cardiac Troponin Assays for Predicting Hospitalization for Acute Coronary Syndrome

et al. 2013

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“…TASH was performed according to routine clinical practice. A description of the pre-and postprocedural management of the patients has recently been published (18 ). All patients received analgesic and anxiolytic pretreatment.…”

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confidence: 99%

“…A 2-tailed P value Ͻ0.05 was considered statistically significant. Table 1 summarizes the clinical and procedural characteristics of all the patients [13 men, 8 women; mean (SD) age, 59.0 (13.29) years] enrolled in the study; these data have been described in detail elsewhere (18 ). All TASH procedures were performed with a single septal branch occlusion in a single-session procedure.…”

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confidence: 99%

“…It reaches a maximum after 90 min and returns to baseline concentrations after 24 h. We used the TASH procedure as a model of AMI because it closely mimics the pathophysiology of AMI and permits a well-defined chronological assignment of biomarker release in response to the initiation of myocardial infarction (18 ). We cannot entirely exclude the possibility that this early increase in copeptin is partly related to the pain and stress caused by the TASH procedure itself; however, all patients received analgesic and anxiolytic pretreatment to lower their stress levels.…”

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Release Kinetics of Copeptin in Patients Undergoing Transcoronary Ablation of Septal Hypertrophy

et al. 2013

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BACKGROUND The release kinetics of copeptin in patients with acute myocardial infarction (AMI) have been difficult to establish. METHODS We analyzed the release kinetics of copeptin in patients with hypertrophic obstructive cardiomyopathy undergoing transcoronary ablation of septal hypertrophy (TASH) as a model of AMI. We included 21 consecutive patients who underwent TASH. Blood samples were collected before and at 15, 30, 45, 60, 75, 90, and 105 min, and at 2, 4, 8, and 24 h after TASH. Serum copeptin was quantified by a sandwich immunoluminometric assay. RESULTS All patients had copeptin concentrations below the 99th percentile at baseline. The median copeptin concentration was significantly increased at 30 min [16.0 pmol/L; interquartile range (IQR), 13.4–20.2 pmol/L], compared with the median baseline concentration (6.6 pmol/L; IQR, 5.3–8.3 pmol/L; P = 0.002). The copeptin concentration peaked 90 min after induction of myocardial infarction and returned to baseline concentrations (median, 8.2 pmol/L; IQR, 6.3–10.1) after 24 h, compared with the above baseline values (P = 0.06). Serum creatine kinase (CK) activities were significantly increased above baseline values by 1 day after TASH [median maximal postprocedural CK activity, 935.0 U/L (IQR, 545.5–1115.0 U/L); median baseline CK activity, 80.0 U/L (IQR, 63.5–109.0 U/L); P < 0.001]. CONCLUSIONS Our results provide additional evidence that early rule-out of suspected AMI is possible by using the copeptin concentration in combination with cardiac troponin T.

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Emerging roles of thioredoxin cycle enzymes in the central nervous system

Patenaude¹,

Murthy

Mirault

2005

CMLS, Cell. Mol. Life Sci.

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The thioredoxins (Trxs) constitute a family of enzymes which catalyze the reduction of protein disulfide bonds. Recent animal studies have revealed the importance of the Trx superfamily in various experimental systems. For example, the homozygous disruption of the genes encoding cytoplasmic (TRX1) or mitochondrial Trx (TRX2) in mice generates lethal embryonic phenotypes. In contrast, transgenic mice overexpressing TRX1 show an extended life span and are relatively resistant to ischemia- mediated brain damage. In addition to their capacity to detoxify peroxides in concert with peroxiredoxins and Trx reductases, Trx isozymes perform multiple redox signaling functions mediated by their specific interaction with various proteins, including redox-regulated kinases and transcription factors. Recent studies indicate that specific isoforms of Trx cycle enzymes, targeted to different cell compartments, are key regulators of fundamental processes, such as gene expression, cell growth and apoptosis. The present review is primarily focused on the emerging neuroprotective role of these proteins in the central nervous system.

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Release Kinetics of Cardiac Biomarkers in Patients Undergoing Transcoronary Ablation of Septal Hypertrophy

Abstract: BACKGROUND:The release kinetics of cardiac troponin T measured with conventional vs high-sensitivity cardiac troponin T (hs-cTnT) assays in patients with acute myocardial infarction (AMI) is difficult to establish.

Cited by 40 publications

References 37 publications

Ninety-Minute vs 3-h Performance of High-Sensitivity Cardiac Troponin Assays for Predicting Hospitalization for Acute Coronary Syndrome

Ninety-Minute vs 3-h Performance of High-Sensitivity Cardiac Troponin Assays for Predicting Hospitalization for Acute Coronary Syndrome

Release Kinetics of Copeptin in Patients Undergoing Transcoronary Ablation of Septal Hypertrophy

Emerging roles of thioredoxin cycle enzymes in the central nervous system

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