Release kinetics study of fatty acids eutectic mixture gated mesoporous carbon nanoparticles for chemo-photothermal therapy

Lü, Hong‐Yan; Liu, Nan; Sun, Tao; Li, Zhu; Luo, Xinyi; Zhao, Qinfu; Wang, Siling

doi:10.1016/j.colsurfa.2023.131450

Cited by 8 publications

(2 citation statements)

References 49 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Photothermal therapy (PTT), which treats tumors by inducing the apoptosis of cancer cells through the generation of heat using near-infrared photothermal agents, has garnered attention for its distinct benefits, including high specificity, powerful selectivity, and manageability. − However, when treating cancer with PTT alone, entire tumor eradication is difficult because of the uneven distribution of heat, which inevitably leads to tumor recurrence. , An excellent way to increase the effectiveness of the treatment is to combine PTT with other therapeutic modalities that take advantage of the benefits of diverse approaches. , Among other combination therapies, photothermal/chemotherapy has been identified as a promising method. , Chemotherapy is the most commonly used and has an inhibitory effect on a large number of tumors among the traditional treatment methods, while doxorubicin hydrochloride (DOX) is a clinically used broad-spectrum chemotherapeutic drug. , In the strategy, the heat generated by photothermal agents can boost drug release precisely in the area that has been exposed to radiation and increase cancer cells’ drug uptake, resulting in a synergistic therapeutic effect . Meanwhile, PTT combined with chemotherapy can effectively induce the body’s immunity to inhibit tumor metastasis .…”

Section: Introductionmentioning

confidence: 99%

“…11,12 In the strategy, the heat generated by photothermal agents can boost drug release precisely in the area that has been exposed to radiation and increase cancer cells' drug uptake, resulting in a synergistic therapeutic effect. 13 Meanwhile, PTT combined with chemotherapy can effectively induce the body's immunity to inhibit tumor metastasis. 14 The challenge of this enhancement strategy is that nanomaterials can act not only as PTT function agents but also as carriers to selectively deliver small molecule anticancer drugs to tumors.…”

Section: ■ Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Bioorthogonal Glycoengineering-Mediated Multifunctional Liquid Metal Nanoprobes for Highly Efficient Photoacoustic Imaging-Guided Photothermal/Chemotherapy of Tumor

Wang

Zhang

et al. 2023

ACS Appl. Bio Mater.

View full text Add to dashboard Cite

The development of a multifunctional cancer diagnosis and treatment platform offers excellent prospects for the effective eradication of malignant solid tumors. Herein, a doxorubicin hydrochloride (DOX)-loaded tannic acid (TA)coated liquid metal (LM) multifunctional nanoprobe was synthesized and applied as a highly efficient platform for the photoacoustic (PA) imaging-guided photothermal/chemotherapy of tumor. The multifunctional nanoprobes exhibited strong nearinfrared absorption, a remarkable photothermal conversion efficiency (PCE) of 55%, and high DOX loading capacity. Combined with the large intrinsic thermal expansion coefficient of LM, highly efficient PA imaging and effective drug release were realized. The LM-based multifunctional nanoprobes were specifically adsorbed into the cancer cells and tumor tissues via glycoengineering biorthogonal chemistry. The in vitro and in vivo photothermal/chemo-anticancer activity confirmed their promising potential in cancer treatment. The subcutaneous breast tumor-bearing mice completely recovered in 5 days under light illumination with clear PA imaging presentation, which showed better antitumor outcomes than single-mode chemotherapy or photothermal therapy (PTT), while keeping side effects at a minimum. Such an LM-based PA imaging-guided photothermal/chemotherapy strategy provided a valuable platform for resistant cancer precise treatment and intelligent biomedicine.

show abstract

Section: Introductionmentioning

confidence: 99%

Section: ■ Introductionmentioning

confidence: 99%

Bioorthogonal Glycoengineering-Mediated Multifunctional Liquid Metal Nanoprobes for Highly Efficient Photoacoustic Imaging-Guided Photothermal/Chemotherapy of Tumor

Wang

Zhang

et al. 2023

ACS Appl. Bio Mater.

View full text Add to dashboard Cite

show abstract

Eutectic Mixtures of APIs: A way to Improve the Physiochemical Properties and Oral Bioavailability of the Drugs

Singh,

Sharma,

Singh Raman@

et al. 2024

ChemistrySelect

View full text Add to dashboard Cite

Eutectic mixtures (EMs) are consisted of two or more components with a specific composition and melting point, have received a lot of attention in pharmaceutical research due to their potential to improve the physicochemical properties and oral bioavailability of active pharmaceutical ingredients (APIs). This review summarizes the most recent research on eutectic combinations of APIs and their use in pharmaceutical formulations. First, the fundamental concepts and characteristics of EMs are reviewed, focusing on their distinct thermodynamic properties and possible advantages in drug delivery systems. The tactics used for forming and characterizing EMs are then described, including techniques such as thermal analysis, spectroscopy, and microscopy. The review delves into the diverse approaches utilized to enhanced the solubility, dissolution rate and oral absorption of poorly water‐soluble APIs through the formation of EMs, including the selection of suitable co‐formers, optimization of composition ratios, and formulation techniques. Furthermore, notable examples of EMs in pharmaceutical development are presented, showcasing their efficacy in enhancing the bioavailability of a wide range of drug compounds across different therapeutic classes. Overall, this review covers the potential of EMs as a promising approach to address formulation challenges and improve the therapeutic performance of APIs, paving the way for the development of more effective and patient‐friendly drug products.

show abstract

Mesoporous carbon in biomedicine: Modification strategies and biocompatibility

Zhang

Zhao

et al. 2023

Carbon

View full text Add to dashboard Cite

Release kinetics study of fatty acids eutectic mixture gated mesoporous carbon nanoparticles for chemo-photothermal therapy

Cited by 8 publications

References 49 publications

Bioorthogonal Glycoengineering-Mediated Multifunctional Liquid Metal Nanoprobes for Highly Efficient Photoacoustic Imaging-Guided Photothermal/Chemotherapy of Tumor

Bioorthogonal Glycoengineering-Mediated Multifunctional Liquid Metal Nanoprobes for Highly Efficient Photoacoustic Imaging-Guided Photothermal/Chemotherapy of Tumor

Eutectic Mixtures of APIs: A way to Improve the Physiochemical Properties and Oral Bioavailability of the Drugs

Mesoporous carbon in biomedicine: Modification strategies and biocompatibility

Contact Info

Product

Resources

About