2015
DOI: 10.1016/j.ijpharm.2015.07.004
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Release mechanisms of tacrolimus-loaded PLGA and PLA microspheres and immunosuppressive effects of the microspheres in a rat heart transplantation model

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Cited by 27 publications
(11 citation statements)
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“…The relatively lower volume of the gel reduces the barrier to diffusion and thus, increases the degradation and drug release rates. Previous research has corroborated that the release rate of tacrolimus from the microspheres decreased with an increase in the PLGA content (Kojima et al, 2015).…”
Section: Discussionmentioning
confidence: 70%
“…The relatively lower volume of the gel reduces the barrier to diffusion and thus, increases the degradation and drug release rates. Previous research has corroborated that the release rate of tacrolimus from the microspheres decreased with an increase in the PLGA content (Kojima et al, 2015).…”
Section: Discussionmentioning
confidence: 70%
“…More comprehensive pharmacokinetic work, together with allotransplantation animal study, is currently underway, and results will be presented in a separate paper. As exhibited in Table 4, plasma concentrations of tacrolimus during a 28-day period after administration were stable at approximately 10 ng/mL, a level generally considered clinically relevant [23,26]. Therefore, the linear in vitro release rates reflected consistent in vivo plasma concentrations.…”
Section: Resultsmentioning
confidence: 95%
“…This system has been utilized to treat various diseases successfully when inconvenience and limitations related to chronic oral treatments cannot be avoided [46]. Another application is the encapsulation of tacrolimus (TAC), which is effective in controlling rejection in the porcine small bowel transplantation and improving the allograft survival time in a heart transplant rat model while avoiding side effects [47,48].…”
Section: Microspherementioning
confidence: 99%