Release of Amino Acids, Fluorescamine-Reactive Substances and Substance P from the Epidermis of the Living Animal

Wormser, Uri; Shoham, Shai; Brodsky, Berta

doi:10.1159/000029851

Cited by 1 publication

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“…We have shown that substance P is released from skin terminals upon exposure to high temperature and exposure to the alkylating agent nitrogen mustard (8). It was assumed that substance P is involved in the initiation of the inflammatory process, leading to the erythema, edema and finally to blister and ulceration.…”

Section: Mechanism Of the Protective Activity Of Iodinementioning

confidence: 99%

Development of Protective Agent Against Sulfur Mustard-Induced Skin Lesions

Wormser¹

2002

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Public reporting burden for this collection of information is estimated to average 1 hour per response, including the time for reviewing instructions, searching existing data sources, gathering and maintaining the data needed and completing and reviewing this collection of information. Send comments regarding this burden estimate or any other aspect of this collection of information, including suggestions for reducing this burden to Washington Headquarters Services, Directorate for Information Operations and Reports, 1215 Jefferson Davis Highway, Suite 1204, Arlington, VA 22202-4302, and AUTHOR(S)Uri Wormser, Ph.D. PERFORMING ORGANIZATION NAME(S) AND ADDRESS(ES)The Sulfur mustard (SM) is a powerful chemical warfare vesicant. No efficient pharmacological antidote is available against this blisterogen. The present study demonstrates the protective effect of newly developed iodine preparation for topical treatment after exposure to SM. In the haired guinea pig model, post-exposure treatment with iodine reduced the degree of skin lesions caused by lul SM. We have seen that intervals of 15, 30, and 45 min between exposure and treatment caused statistically significant reduction of 93%, 91% and 50%, respectively, in ulceration area. Longer interval of 60 min also reduced the lesion by 50% but without statistical significance. The longer was iodine left on the skin the better was the protection achieved, whereas the best protection was observed when iodine was left 2 hours on skin. There was also relationship between degree of protection and SM dose. GC-MS studies showed that iodine did not chemically modified SM. We continued to attempt identifying the previously reported protective factor produced in iodine-treated skin by HPLC and HPLC-MS. In the near future intensive effort will be invested in this issue and in further establishment of the protective effect of iodine.14. SUBJECT TERMSo mustard gas, skin, povidone iodine, neuropeptides PI -Signature Date INTRODUCTIONSulfur mustard [C1-CH 2 -CH 2 -S-CH2-CH 2 -C1] is a highly potent alkylating agent and severely cytotoxic vesicant Topical exposure to SM results in erythema which appears within hours of intoxication followed by edema, blistering and ulceration observed within tens of hours following poisoning (1-5). The devastating effect of SM was demonstrated in several conflicts in this century emphasizing the great need of an efficient pharmacological antidote against mustard gas toxicity. Numerous compounds have been tested for their antidotal activity against SM however, they were too weak to be used as protectants against the vesicant. The purpose of the present study was to develop a pharmacological antidote for post-exposure treatment ofSM-exposed individuals.

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Section: Mechanism Of the Protective Activity Of Iodinementioning

confidence: 99%

Development of Protective Agent Against Sulfur Mustard-Induced Skin Lesions

Wormser¹

2002

Self Cite

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Release of Amino Acids, Fluorescamine-Reactive Substances and Substance P from the Epidermis of the Living Animal

Cited by 1 publication

References 16 publications

Development of Protective Agent Against Sulfur Mustard-Induced Skin Lesions

Development of Protective Agent Against Sulfur Mustard-Induced Skin Lesions

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