Release of creatine phosphokinase from muscle—I

Meltzer, Herbert Y.; Margulies, Paul

doi:10.1016/0006-2952(71)90455-2

Biochemical Pharmacology

1971

DOI: 10.1016/0006-2952(71)90455-2

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Release of creatine phosphokinase from muscle—I

Herbert Y. Meltzer

Paul Margulies

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1973

1977

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Cited by 9 publications

References 23 publications

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Serotonin-Induced Muscle Weakness

Patten¹,

Oliver²,

Engel³

1974

Archives of Neurology

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Infusions of serotonin into a rat nervemuscle preparation decreased the force of the evoked twitch of anterior tibial and soleus muscles. Antiserotonin drugs (cyproheptadine hydrochloride, methysergide, chlorpromazine hydrochloride) prevented the adverse effect of serotonin if they were given prior to the serotonin infusion. These experiments support the hypothesis that serotonin may play a role in some diseases of muscle.

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Serotonin-Induced Muscle Weakness

Patten¹,

Oliver²,

Engel³

1974

Archives of Neurology

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Antimicrobial Action of Compound 48/80 against Protozoa, Bacteria, and Fungi

Lenney

Siddiqui

Schnell

et al. 1977

Journal of Pharmaceutical Sciences

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Screening of malignant hyperthermia susceptible families by creatine phosphokinase measurement and other clinical investigations

Britt

Endrényi

Peters

et al. 1976

Canad. Anaesth. Soc. J.

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We investigated 56 families afflicted with malignant hyperpyrexia. One hundred and twenty-four individuals within these families had had an episode of malignant hyperthermia, of whom we saw seventy-two. Serum creatine phosphokinase (CPK) was statistically higher in affected individuals and in close relatives than in normal volunteers. The magnitude of the serum CPK elevations varied significantly between families. While in some families the serum CPK was clearly elevated in affected individuals, in other families the serum CPK was normal or only moderately or inconsistently raised. In these latter families serum CPK measurement was therfore of little or no value in identifying afflicted members. The incidence of musculoskeletal abnormalities was greater in affected individuals and in close relatives than in the general population. Thus, the concomitant individual belonging to a family known to be susceptible to malignant hyperthermia was a better indicator of the MH trait than was the presence of only one of these parameters. For reasons which we do not fully understand, MHS individuals were found to require fewer anaesthetics than normal persons. The incidence of MH crises within each family fell significantly following investigation, counselling, and issuance of Medic-Alert bracelets.

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Release of creatine phosphokinase from muscle—I

Cited by 9 publications

References 23 publications

Serotonin-Induced Muscle Weakness

Serotonin-Induced Muscle Weakness

Antimicrobial Action of Compound 48/80 against Protozoa, Bacteria, and Fungi

Screening of malignant hyperthermia susceptible families by creatine phosphokinase measurement and other clinical investigations

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