Release of Drugs from IUDs Using an Ethylene Vinyl Acetate Matrix

Wheeler, R. G.; Friel, P.

doi:10.1007/978-1-4757-0737-3_9

Cited by 3 publications

(1 citation statement)

References 13 publications

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“…For example, at high loadings (e.g., for cases of M0.4 and M0.6), release become aggressively erosionlike. Loading levels that affect the microstructure alterations in the monolithic dispersion systems have been theoretically described by percolation theory. − Loadings of soluble fitcBSA/PEG aggregates in this study are in the range of 9−22%. For even higher loadings, for example, up to 50%, the leaching release would actually provide a convenient means to prepare 3-D porous nanofibers with nanotopographical surface features and pronounced increase in surface area as demonstrated elsewhere …”

Section: Resultsmentioning

confidence: 95%

Coaxial Electrospinning of (Fluorescein Isothiocyanate-Conjugated Bovine Serum Albumin)-Encapsulated Poly(ε-caprolactone) Nanofibers for Sustained Release

et al. 2006

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As an aim toward developing biologically mimetic and functional nanofiber-based tissue engineering scaffolds, we demonstrated the encapsulation of a model protein, fluorescein isothiocyanate-conjugated bovine serum albumin (fitcBSA), along with a water-soluble polymer, poly(ethylene glycol) (PEG), within the biodegradable poly(epsilon-caprolactone) (PCL) nanofibers using a coaxial electrospinning technique. By variation of the inner flow rates from 0.2 to 0.6 mL/h with a constant outer flow rate of 1.8 mL/h, fitcBSA loadings of 0.85-2.17 mg/g of nanofibrous membranes were prepared. Variation of flow rates also resulted in increases of fiber sizes from ca. 270 nm to 380 nm. The encapsulation of fitcBSA/PEG within PCL was subsequently characterized by laser confocal scanning microscopy, transmission electron microscopy (TEM), and X-ray photoelectron spectroscopy (XPS) analysis. In vitro release studies were conducted to evaluate sustained release potential of the core-sheath-structured composite nanofiber PCL-r-fitcBSA/PEG. As a negative control, composite nanofiber PCL/fitcBSA/PEG blend was prepared from a normal electrospinning method. It was found that core-sheath nanofibers PCL-r-fitcBSA/PEG pronouncedly alleviated the initial burst release for higher protein loading and gave better sustainability compared to that of PCL/fitcBSA/PEG nanofibers. The present study would provide a basis for further design and optimization of processing conditions to control the nanostructure of core-sheath composite nanofibers and ultimately achieve desired release kinetics of bioactive proteins (e.g., growth factors) for practical tissue engineering applications.

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Section: Resultsmentioning

confidence: 95%