Release of Endogenous Opioids Following Transcutaneous Electric Nerve Stimulation in an Experimental Model of Acute Inflammatory Pain

Sabino, George Schayer; Santos, Cristiane M.F.; Francischi, Janetti Nogueira de; Resende, Marcos Antônio de

doi:10.1016/j.jpain.2007.09.003

Cited by 96 publications

(79 citation statements)

References 35 publications

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“…35) However, others studies reported that blockade of peripheral opioid receptors prevented the analgesic effect produced by low, but not high frequency TENS. [35][36][37] In addition, it was known that a variety of neurotransmitters including endogenous ligand norepinephrine, GABA and serotonin were involved in analgesic actions of TENS.…”

Section: Endogenous Opioid Theorymentioning

confidence: 99%

Basic Understanding of Transcutaneous Electrical Nerve Stimulation

Jung¹,

Byun²,

Choi³

2016

Journal of Oral Medicine and Pain

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Transcutaneous electrical nerve stimulation (TENS) is one of the representative physiotherapical modalities used for the treatment of various musculoskeletal disorders by the application of electrical stimuli. In dental practice, it has long been used in the treatment of acute and chronic orofacial pain conditions including temporomandibular disorders. TENS is the delivery of therapeutic electrical stimuli with a variety of electrical intensity, frequency and duration to stimulate peripheral nerve through surface electrodes with various form and placement. While controversy still remains over the clinical effectiveness and application of TENS, basic understanding of its electrical properties and the expected biological reactions is important to increase the therapeutic effect and decrease the risk of possible side effects. This review, therefore, focuses on basic understanding of TENS including its underlying mechanisms and stimulation parameters.

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Section: Endogenous Opioid Theorymentioning

confidence: 99%

Basic Understanding of Transcutaneous Electrical Nerve Stimulation

Jung¹,

Byun²,

Choi³

2016

Journal of Oral Medicine and Pain

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“…In addition, treatment with a δ-opioid receptor antagonist in the rostroventromedial medulla blocks the analgesic effects of TENS (Kalra et al 2001). Hyperalgesia in arthritic rats was decreased after TENS treatment, and this effect is blocked by the opioid receptor antagonist naltrexone (Sabino et al 2008). Electrical stimulation of peripheral areas increases the levels of neuropeptides that interact with μ-and δ-opioid receptor subtypes in the central nervous system (Han et al 1999;Huang et al 2000).…”

Section: Discussionmentioning

confidence: 99%

A Single Trial of Transcutaneous Electrical Nerve Stimulation Reduces Chronic Neuropathic Pain Following Median Nerve Injury in Rats

Cho

Suh

Han

2014

Tohoku J. Exp. Med.

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Neuropathic pain is a devastating chronic condition and is often induced in the upper limb following nerve injury or damage. Various drugs or surgical methods have been used to manage neuropathic pain; however, these are frequently accompanied by undesirable side effects. Transcutaneous electrical nerve stimulation (TENS) is a safe and non-invasive intervention that has been used to alleviate different types of pain in the clinic, but it is unclear whether TENS can improve chronic neuropathic pain in the upper limb. Thus, the aim of this study was to investigate the effects of a single trial of TENS on chronic neuropathic pain following median nerve injury. Male rats weighing 200-250 g received median nerve-ligation of the right forearm, while the control group received only skin-incision without nerve-ligation. Neuropathic painbehaviors, including mechanical, cold, and thermal allodynia, were measured for 4 weeks. After the development of chronic neuropathic pain, TENS (100 Hz, 200 µs, sub-motor threshold) or placebo-TENS (sham stimulation) was applied for 20 min to the ipsilateral or contralateral side. Neuropathic pain behavior was assessed before and after intervention. Median nerve-ligation significantly induced and maintained neuropathic pain in the ipsilateral side. TENS application to the ipsilateral side effectively attenuated the three forms of chronic neuropathic pain in the ipsilateral side compared to sham-treated rats (peripheral and central effects), while TENS application to contralateral side only reduced mechanical allodynia in the ipsilateral side (central effect). Our findings demonstrate that TENS can alleviate chronic neuropathic pain following median nerve injury.

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“…Supõe-se que o mecanismo de redução da dor nas pacientes, embora não tenha sido estudado, se deva à liberação de opióides endógenos, efeito sugerido pelo uso da TENS de baixa freqüência 12 . Como as pacientes apresentavam dor crônica no ombro, que as impedia de realizar atividades diárias como lavar roupa e pentear o cabelo, optou-se pelo uso da TENS de baixa freqüência porque essa modalidade parece ter um efeito analgésico mais duradouro, observado em pacientes com dor lombar crônica 13 e em modelos animais 14 . Entretanto, não se pode assegurar que a TENS de alta freqüência não desencadeie os mesmos efeitos, visto que alguns estudos sugerem que tanto a TENS de alta quanto de baixa freqüên-cia podem reduzir dores crônicas [15][16][17] .…”

Section: Discussão E Conclusãounclassified

Efeito da estimulação elétrica nervosa transcutânea no tratamento da dor no ombro de pacientes com doença renal crônica: relato de casos

Bertoli¹,

Jorgetti

Moysés

et al. 2009

Fisioter. Pesqui.

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A doença renal crônica (DRC) pode causar muitas complicações clínicas associadas ao tempo de diálise. A amiloidose é uma dessas complicações e pode levar à dor no ombro, comum em pacientes com DRC. Só foram encontrados na literatura relatos de tratamento cirúrgico e/ou medicamentoso para esse tipo de dor. O objetivo aqui foi avaliar o benefício da estimulação elétrica nervosa transcutânea (TENS) no tratamento da dor no ombro devida à amiloidose em pacientes com DRC. Duas pacientes foram avaliadas quatro vezes num período de três meses. Na avaliação inicial as pacientes foram orientadas e receberam um aparelho de TENS para uso domiciliar (10Hz, 150 µs, duas vezes por dia, por 40 minutos) durante três meses. A dor foi avaliada utilizando-se uma escala visual analógica e o questionário de dor de Wisconsin. Os resultados mostram que o tratamento com TENS reduziu a dor no ombro em ambas as pacientes. O tratamento com a TENS pode pois ser eficaz em reduzir a dor no ombro em pacientes com DRC.

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Release of Endogenous Opioids Following Transcutaneous Electric Nerve Stimulation in an Experimental Model of Acute Inflammatory Pain

Cited by 96 publications

References 35 publications

Basic Understanding of Transcutaneous Electrical Nerve Stimulation

Basic Understanding of Transcutaneous Electrical Nerve Stimulation

A Single Trial of Transcutaneous Electrical Nerve Stimulation Reduces Chronic Neuropathic Pain Following Median Nerve Injury in Rats

Efeito da estimulação elétrica nervosa transcutânea no tratamento da dor no ombro de pacientes com doença renal crônica: relato de casos

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