Release of hemopoietic factors by normal human T cell lines with either suppressor or helper activity

Lanfrancone, Luisa; Ferrero, Dario; Gallo, Eugenio; Foà, Robin; Tarella, Corrado

doi:10.1002/jcp.1041220103

Cited by 9 publications

(2 citation statements)

References 43 publications

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“…The data are consistent with a previous report which suggested that murine leukemia virus could increase GM colony stimulating activity from murine fibroblasts (Koury and Pragnell, 1982). That multilineage hematopoietic factors may be produced by mitogen-stimulated human lymphocytes (Iscove et al, 1982), HTLV-infected lymphocytes (KoeMer et al, 1984), and lymphocyte cell lines not infected with retrovirus (Greenberger et al, 1984;Lanfrancone et al, 1985) is also consistent with this concept.…”

Section: Discussionsupporting

confidence: 92%

Multilineage, non‐species specific hematopoietic growth factor(s) elaborated by a feline fibroblast cell line: Enhancement by virus infection

Abkowitz

Holly

Segal

et al. 1986

Journal Cellular Physiology

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In studies designed to determine the role of feline leukemia virus (FeLV) in the pathogenesis of marrow failure in the cat, we tested medium conditioned by uninfected and FeLV-infected feline embryonic fibroblasts (FEA) for its effect on hematopoietic colony growth in culture. As opposed to an inhibitory effect, we found that the conditioned medium (CM) from FEA or FEA/FeLV increased the in vitro growth of multiple hematopoietic progenitor cell types including erythroid burst-forming cells (BFU-E), granulocyte/macrophage colony-forming cells, megakaryocytic colony-forming cells, and mixed-cell colony-forming cells. Furthermore, CM enhanced the growth of progenitors in cultures of mouse or human marrow cells, as well as cat marrow cells. Stimulation of feline BFU-E was most marked with an increment in growth of 400% over control. The human burst promoting activity (BPA) of the CM was equivalent or better than other CM available in our laboratory. The evidence suggest that the growth-promoting activity is a constitutive product(s) released by FEA which was enhanced eightfold with virus infection. Studies with non-adherent and T-lymphocyte-depleted human marrow cells and human peripheral blood cells suggest that the growth factor(s) acts directly on progenitor cells and not through readily identified accessory cells. These findings are consistent with the concept that mesenchymal cells such as fibroblasts have the capacity to release hematopoietic growth factor(s) capable of acting on primitive hematopoietic progenitors. The results provide an example of how injury of such cells, through virus infection, may enhance growth factor(s) release and influence the hematopoietic microenvironment.

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Section: Discussionsupporting

confidence: 92%

Multilineage, non‐species specific hematopoietic growth factor(s) elaborated by a feline fibroblast cell line: Enhancement by virus infection

Abkowitz

Holly

Segal

et al. 1986

Journal Cellular Physiology

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“…GM‐CSF has a partial role in the eosinophil production [ 2]. On the other hand, T lymphocyte isolated from normal individuals do not have similar ability in vitro studies [ 1, 9, 10].…”

Section: Discussionmentioning

confidence: 99%

The interleukin‐5 messenger RNA expression in a patient with idiopathic hypereosinophilic syndrome

Leung

et al. 1998

Clin Experimental Allergy

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Interleukin-5 has a specific role in various eosinophilic activities. It is the predominant cytokine produces by activated T-lymphocytes isolated from patients with idiopathic hypereosinophilic syndrome. We studied a young patient suffering from idiopathic hypereosinophilic syndrome who presented with Horner's syndrome, peripheral neuropathy and skin ulcers. The IL-5 gene expression by CD4+ T-lymphocytes and the peripheral eosinophil count were raised. The skin ulcers continued to deteriorate despite a swift reduction of the IL-5 gene expression and peripheral eosinophil count following systemic corticosteroid treatment. We suggest that peripheral eosinophilia may not be responsible for the damage in skin lesions and more aggressive treatment may be required.

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Circulating Hemopoietic Precursors after High-Dose Cyclophosphamide: Efficacy of In Vivo GM-CSF Administration

Ferrero¹,

Tarella²,

Gallo³

et al. 1990

Experimental Hematology Today—1989

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Release of hemopoietic factors by normal human T cell lines with either suppressor or helper activity

Cited by 9 publications

References 43 publications

Multilineage, non‐species specific hematopoietic growth factor(s) elaborated by a feline fibroblast cell line: Enhancement by virus infection

Multilineage, non‐species specific hematopoietic growth factor(s) elaborated by a feline fibroblast cell line: Enhancement by virus infection

The interleukin‐5 messenger RNA expression in a patient with idiopathic hypereosinophilic syndrome

Circulating Hemopoietic Precursors after High-Dose Cyclophosphamide: Efficacy of In Vivo GM-CSF Administration

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