Release of Histamine from Mast Cells by Vasoactive Peptides

Johnson, Alice; Erdös, Ervin G.

doi:10.3181/00379727-142-37219

Cited by 332 publications

(122 citation statements)

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“…There is evidence that SP can release histamine from mast cells (Johnson & Erdos, 1973;Erjavee et al, 1981) and it has been suggested that mast cell histamine plays a part in vasodilatation following electrical stimulation of cutaneous nerves (Lembeck & Holzer, 1979). However, in this study, vasodilatation induced by antidromic stimulation was not influenced by mepyramine plus cimetidine, indicating that the vascular response was not mediated by the release of histamine from mast cells.…”

Section: Effect Of Electrical Stimulation Of the Sciatic Nerve On Cutcontrasting

confidence: 71%

Involvement of substance P present in primary afferent neurones in modulation of cutaneous blood flow in the instep of rat hind paw

Yonehara

Chen

Imai

et al. 1992

British J Pharmacology

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1 The participation of small-diameter afferent fibres in the microcirculatory haemodynamics of cutaneous tissue was examined by studies on the effects of antidromic stimulation of primary afferent neurones on cutaneous blood flow (CBF) and tachykinin release into the subcutaneous space in the instep of the hind paw of rats. 2 Antidromic stimulation of the sectioned sciatic nerve induced a biphasic flow response, an initial transient decrease followed by an increase, with no alteration in the blood pressure. 3 Neither phase was affected by pretreatment with phentolamine (0.1 mg kg-', i.a.), propranolol (0.5 mg kg', i.a.), atropine (0.5 mg kg', i.a.), methysergide (0.5 mg kg', i.a.) or mepyramine (10mg kg-', i.a.) plus cimetidine (10 mg kg-', i.a.), but both were significantly inhibited by pretreatment with capsaicin (50mg kg-', s.c.).4 Spantide (1-2tgmolkg-', i.a.), a substance P (SP) antagonist, reduced the basal CBF, and also inhibited both phases of the biphasic flow response evoked by antidromic stimulation of the sectioned sciatic nerve. 5 Intra-arterial infusion of SP (0.5 Mmol kg-', i.a.) induced a biphasic flow response similar to that elicited by antidromic stimulation of the sectioned sciatic nerve. 6 Antidromic stimulation of the sectioned sciatic nerve caused a marked increase in SP release into the subcutaneous perfusate of the instep of the rat hind paw, but no detectable increase in neurokinin A release. 7 We suggest that SP and its receptors are mainly responsible for the vascular response induced by stimulation of the sectioned sciatic nerve, and that small-diameter afferent fibres containing SP tonically regulate vascular tone in cutaneous microvessels.

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Section: Effect Of Electrical Stimulation Of the Sciatic Nerve On Cutcontrasting

confidence: 71%

Involvement of substance P present in primary afferent neurones in modulation of cutaneous blood flow in the instep of rat hind paw

Yonehara

Chen

Imai

et al. 1992

British J Pharmacology

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“…Thus it is likely that in the isolated perfused heart the overall action of bradykinin will be the resultant not only of the stimulation of sensory nerve endings but also of a direct effect on its own receptor(s) on the coronary vasculature (Toda, 1977;Regoli & Barab&, 1980;Beny et al, 1987), and release of prostaglandin (Goldberg et al, 1976;Warren et al, 1987) and/or histamine (Johnson & Erdos, 1973). It is important to emphasize that, to obtain detectable release of sensory neuropeptides we used a high concentration of bradykinin.…”

Section: Discussionmentioning

confidence: 99%

A comparison of bradykinin‐ and capsaicin‐induced myocardial and coronary effects in isolated perfused heart of guinea‐pig: involvement of substance P and calcitonin gene‐related peptide release

Manzini

Perretti

Benedetti

et al. 1989

British J Pharmacology

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1 Bradykinin and capsaicin were compared for their ability to elicit functional effects and to release sensory neuropeptides from guinea-pig isolated perfused hearts. 2 Both bradykinin (1O/M) and capsaicin (1 pM) produced a marked increase in coronary flow, a large positive chronotropic effect and a significant reduction in contractile strength. These actions were associated with a marked release of substance P-like immunoreactivity (SP-LI) and calcitonin gene-related-like immunoreactivity (CGRP-LI). The percentage of the tissue content of SP-LI and CGRP-LI released by each agent was similar, although bradykinin was less effective than capsaicin. The ratio of SP-LI/CGRP-LI released by both agents was similar to that present in cardiac tissue. 3 Neuropeptide release could be evoked only once with capsaicin but at least four times with bradykinin. Also, functional responses to capsaicin underwent desensitization. After either in vitro or systemic capsaicin pretreatment, the release of SP-LI and CGRP-LI by bradykinin was reduced and the positive chronotropic effect of bradykinin was significantly reduced, while the increase in coronary flow and negative inotropic responses remained unchanged. 4 Pretreatment with indomethacin (10/M) strongly antagonized the release of SP-LI and CGRP-LI by bradykinin and reduced the increase in heart rate. 5 These findings suggest that activation by bradykinin (probably through indirect mechanisms) of capsaicin-sensitive sensory nerves in the heart, leads to a local release of sensory neuropeptides. These neuropeptides, in turn, could participate in determining the complex functional effects of this kinin on cardiac performance.

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“…Degranulation may occur by release of active constituents from granules in situ, or there may be severe disruption of the cytoplasm and shedding of granules (Selye 1965). Biologic polymers which can degranulate mast cells occur in insect saliva (Johnson and Erdos 1973) and venoms (Habermann 1972) and there is a degranulating agent in Nippostrongylus braziliensis (Uvnas and Wold 1967). While there was no mast cell destruction in previously unexposed animals, a low degree of degranulation did occur.…”

Section: Discussionmentioning

confidence: 99%

Boophilus microplus : Cellular Responses to Larval Attachment and Their Relationship to Host Resistance

Schleger¹,

Lincoln²,

McKenna³

et al. 1976

Aust. Jnl. Of Bio. Sci.

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The histology of early feeding lesions of the cattle tick B. microp/us has been studied using 32p labelled larvae to standardize the duration of attachment. Critical studies were made on 3-h lesions in six separate experiments on different groups of British breed animals. Each group consisted of three animals-one previously unexposed to ticks, one of high resistance and one of low resistance.The degree of mast cell disruption, eosinophil concentration and degranulation, and the extent of epidermal vesiculation were all significantly greater at the site of attachment on highly resistant hosts. In previously unexposed animals there was no mobilization of eosinophils nor mast cell breakdown and no epidermal vesiculation.Possible immune mechanisms producing mast cell disruption and the infiltration and concentration of eosinophils are suggested, and the effect of eosinophil degranulation on larval attachment and feeding is discussed.

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Release of Histamine from Mast Cells by Vasoactive Peptides

Cited by 332 publications

References 0 publications

Involvement of substance P present in primary afferent neurones in modulation of cutaneous blood flow in the instep of rat hind paw

Involvement of substance P present in primary afferent neurones in modulation of cutaneous blood flow in the instep of rat hind paw

A comparison of bradykinin‐ and capsaicin‐induced myocardial and coronary effects in isolated perfused heart of guinea‐pig: involvement of substance P and calcitonin gene‐related peptide release

Boophilus microplus : Cellular Responses to Larval Attachment and Their Relationship to Host Resistance

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