Release of muscle α-actin into serum after intensive exercise

Martínez‐Amat, Antonio; Marchal, Juan Antonio; J, Prados; Hita, Francisco Luna; Rodríguez-Serrano, Fernando; Boulaiz, Houría; Martín, I; Melguizo, Consolación; Caba, Octavio; Vélez, Celia; Ortiz, Rudy M.; Rama, Aisha; Aránega, Amelia

doi:10.5604/20831862.927491

Cited by 3 publications

(2 citation statements)

References 22 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…[ 9–15 ] As reported in previous studies, tissue injuries lead to site‐dependent environmental changes and abnormal cellular activity. Multiple factors, including enzymes, [ 16–36 ] reduction and oxidation (redox) reactions, [ 37–44 ] hypoxia, [ 32,45–49 ] pH, [ 47,50–54 ] temperature, [ 55–57 ] and the other characteristics, [ 42,58–60 ] become dysregulated at the onset of injury or during the progression of the healing ( Figure A). These hallmarks can be monitored to serve as a reference to evaluate the extent of injury, stage of wound healing, and necessity for treatment.…”

Section: Introductionmentioning

confidence: 99%

Stimuli‐Responsive Delivery of Growth Factors for Tissue Engineering

Jiang

Zhou

et al. 2020

Adv Healthcare Materials

105

View full text Add to dashboard Cite

Growth factors (GFs) play a crucial role in directing stem cell behavior and transmitting information between different cell populations for tissue regeneration. However, their utility as therapeutics is limited by their short half‐life within the physiological microenvironment and significant side effects caused by off‐target effects or improper dosage. “Smart” materials that can not only sustain therapeutic delivery over a treatment period but also facilitate on‐demand release upon activation are attracting significant interest in the field of GF delivery for tissue engineering. Three properties are essential in engineering these “smart” materials: 1) the cargo vehicle protects the encapsulated therapeutic; 2) release is targeted to the site of injury; 3) cargo release can be modulated by disease‐specific stimuli. The aim of this review is to summarize the current research on stimuli‐responsive materials as intelligent vehicles for controlled GF delivery; Five main subfields of tissue engineering are discussed: skin, bone and cartilage, muscle, blood vessel, and nerve. Challenges in achieving such “smart” materials and perspectives on future applications of stimuli‐responsive GF delivery for tissue regeneration are also discussed.

show abstract

Section: Introductionmentioning

confidence: 99%

Stimuli‐Responsive Delivery of Growth Factors for Tissue Engineering

Jiang

Zhou

et al. 2020

Adv Healthcare Materials

105

View full text Add to dashboard Cite

show abstract

“…ACTA1 and TPM2 are only expressed in striated muscle. ACTA1 in the circulation is a well-reported candidate for muscle damage caused by physical damage or intensive exercise [ 39 , 40 , 41 , 42 ]. Injury could lead to an increase (up to 187 times) in ACTA1 levels in the serum [ 40 ].…”

Section: Discussionmentioning

confidence: 99%

Potential Muscle-Related Biomarkers in Predicting Curve Progression to the Surgical Threshold in Adolescent Idiopathic Scoliosis—A Pilot Proteomic Study Comparing Four Non-Progressive vs. Four Progressive Patients vs. A Control Cohort

Wang

Chen

Zhang

et al. 2021

JCM

View full text Add to dashboard Cite

Previous studies have reported abnormal muscle morphology and functions in patients with adolescent idiopathic scoliosis (AIS). To answer whether such abnormalities could be reflected in their circulation and their clinical implication for predicting curve progression to the surgical threshold, this preliminary study explored the presence of baseline muscle-related proteins and their association with curve progression. Plasma samples were collected at the first clinical visit for AIS, with patients divided into non-progressive or progressive groups (N = four and four) according to their Cobb angle in six-year follow-ups, with age- and sex-matched healthy subjects (N = 50). Then, the samples were subjected to isobaric tags for relative and absolute quantitation (iTRAQ) for global comparison of untargeted protein expression. Seventy-one differentially expressed proteins (DEPs) were found elevated in progressive AIS. Functional analysis showed that 18 of these are expressed in muscles and play an essential role in muscle activities. Among the muscle-related DEPs, α-actin had the highest fold change in progressive/non-progressive groups. This preliminary study firstly suggested higher circulating levels of muscle structural proteins in progressive AIS, indicating the likelihood of structural damage at the microscopic level and its association with progression to the surgical threshold. Further studies with larger sample sizes are warranted to validate these novel candidates for early diagnosis and predicting progression.

show abstract