Release of neutrophil elastase and its role in tissue injury in acute inflammation: effect of the elastase inhibitor, FR134043

Fujie, Keiko; Shinguh, Yasuhiko; Inamura, Noriaki; Yasumitsu, Ritsuko; Okamoto, Masanori; Okuhara, Masakuni

doi:10.1016/s0014-2999(99)00268-x

Cited by 59 publications

(52 citation statements)

References 38 publications

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“…27) In the present study, the antibody level to type II collagen was moderately low as compared to the other groups, when LMWCS was orally administered.…”

Section: Discussioncontrasting

confidence: 40%

“…26) Because elastase can readily degrade matrix proteins, the inhibitors are likely the therapeutic advantage in these pathogenic conditions of arthritis. 27) Volpi reported that glycosaminoglycans, such as CS and heparin, have the ability to inhibit the leukocyte elastase activity because of their charge density. 20,22) Unlike previous reports, we found that LMWCS is superior to CS in terms of inhibiting elastase activity in vitro when applied at the same dose (Fig.…”

Section: Discussionmentioning

confidence: 99%

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Effects of Low Molecular Weight Chondroitin Sulfate on Type II Collagen-Induced Arthritis in DBA/1J Mice

Cho

Sim

Jeong

et al. 2004

Biological & Pharmaceutical Bulletin

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Chondroitin sulfate (CS) is a glycosaminoglycan, which is composed of an alternating sequence of sulfated and/or unsulfated residue of D-glucuronic acid (GlcA) and D-N-acetylgalactosamine (GalNAc) linked by b(1→3) and b(1→4) bonds.1) CS is a major class of glycosaminoglycans required for the formation of proteoglycans found in the joint cartilage. It has been well established that basic damage to the arthritic cartilage involves the alteration of proteoglycans and collagen fibers.

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“…27) In the present study, the antibody level to type II collagen was moderately low as compared to the other groups, when LMWCS was orally administered.…”

Section: Discussioncontrasting

confidence: 40%

Section: Discussionmentioning

confidence: 99%

Effects of Low Molecular Weight Chondroitin Sulfate on Type II Collagen-Induced Arthritis in DBA/1J Mice

Cho

Sim

Jeong

et al. 2004

Biological & Pharmaceutical Bulletin

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“…The former mechanism results from the generation of reactive oxygen species (27), whereas the latter mechanism reflects the capacity of PMNs to degranulate and release preformed oxidants and proteolytic enzymes from granules (3,48). Neutrophil degranulation is meant to target the offending pathogen; however, these powerful substances may cause the destruction of neighboring cells and dissolution of tissue (13,23). This neutrophil-dependent tissue damage is known as the neutrophil paradox, where the defending cells become an enemy (47).…”

mentioning

confidence: 99%

Neutrophil Responses toMycobacterium tuberculosisInfection in Genetically Susceptible and Resistant Mice

et al. 2005

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The role of neutrophils in tuberculosis (TB) resistance and pathology is poorly understood. Neutrophil reactions are meant to target the offending pathogen but may lead to destruction of the host lung tissue, making the defending cells an enemy. Here, we show that mice of the I/St strain which are genetically susceptible to TB show an unusually high and prolonged neutrophil accumulation in their lungs after intratracheal infection. Compared to neutrophils from more resistant A/Sn mice, I/St neutrophils display an increased mobility and tissue influx, prolonged lifespan, low expression of the CD95 (Fas) apoptotic receptor, relative resistance to apoptosis, and an increased phagocytic capacity for mycobacteria. Segregation genetic analysis in (I/St ؋ A/Sn)F 2 hybrids indicates that the alleles of I/St origin at the chromosome 3 and 17 quantitative trait loci which are involved in the control of TB severity also determine a high level of neutrophil influx. These features, along with the poor ability of neutrophils to restrict mycobacterial growth compared to that of lung macrophages, indicate that the prevalence of neutrophils in TB inflammation contributes to the development of pathology, rather than protection of the host, and that neutrophils may play the role of a "Trojan horse" for mycobacteria.

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“…Because elastase can readily degrade matrix proteins, the inhibitors are likely the therapeutic advantage in these pathogenic conditions of arthritis (Fujie et al, 1999).…”

Section: Effect Of Buoh Fraction On the Inhibition Of Elastase Activitymentioning

confidence: 99%

Effects of the Butanol Extact of Head of Panax Ginseng on Type II Collagen-induced Arthritis in DBA/1J Mice

Jeong¹

2007

Biomolecules and Therapeutics

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− In order to evaluate the improvement effects of head of Panax ginseng on chronic arthritis, we have investigated the activity of butanol fraction (BuOH fraction) in vitro and in vivo system. BuOH fraction showed significant inhibition on the elastase activity. Anti-arthritic activity of BuOH fraction was also examined on type II collagen-induced arthritis in DBA/1J mice. Mice were immunized with injection of type II collagen emulsified in Freund's complete adjuvant, followed by a booster injection 21 days later. BuOH fraction(BHPG) was administered at an oral dose of 500mg/kg for 2 weeks from the 1st day boost. The hind paw edema was significantly decreased in the group of treatment with BuOH fraction compared to control. In collagen-induced DBA/1J mice, BuOH fraction did not affected the collagen antibody titer but significantly inhibited the tumor necrosis factoralpha(TNF-α) activity. These results were confirmed with histological evaluation of joint tissues. This study may raise the possibility that the usage of BuOH fraction of head of Panax ginseng as alternative medicine for the relief and prevention of rheumatoid arthritis symptoms.

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Release of neutrophil elastase and its role in tissue injury in acute inflammation: effect of the elastase inhibitor, FR134043

Cited by 59 publications

References 38 publications

Effects of Low Molecular Weight Chondroitin Sulfate on Type II Collagen-Induced Arthritis in DBA/1J Mice

Effects of Low Molecular Weight Chondroitin Sulfate on Type II Collagen-Induced Arthritis in DBA/1J Mice

Neutrophil Responses toMycobacterium tuberculosisInfection in Genetically Susceptible and Resistant Mice

Effects of the Butanol Extact of Head of Panax Ginseng on Type II Collagen-induced Arthritis in DBA/1J Mice

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