Release of peptide YY and inhibition of gastric acid secretion by long‐chain and medium‐chain triglycerides but not by sucrose polyester in men

Maas, M.I.M.; Hopman, W. P. M.; Katan, Martijn B.; Jansen, J. B. M. J.

doi:10.1046/j.1365-2362.1998.00255.x

Cited by 35 publications

(22 citation statements)

References 59 publications

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“…35 The infusion of fat into the duodenum also induces a duodenal brake 18. These effects are probably due to the stimulation of specialised mucosal cells such as I cells of the duodenojejunum that secrete cholecystokinin,2 31 34 or due to the release of peptide YY,36 both of which can delay gastric emptying. Thus, the prolonged colonic motor response that is induced by a fat meal may in part be due to the slower transit of this meal through the upper gut and the release of cholecystokinin 31…”

Section: Discussionmentioning

confidence: 99%

Effects of fat and carbohydrate meals on colonic motor response

Rao

2000

Gut

101

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Background-Ingestion of a meal stimulates colonic motility. It is unclear whether the nutrient composition of a meal aVects colonic motor response. Aims-To investigate and compare the eVects of a predominantly fat or carbohydrate meal on colonic motility. Methods-In 18 healthy subjects, ambulatory colonic manometry was performed by placing a six sensor, solid state probe from the mid-transverse colon to the rectum. In a randomised, crossover design, 10 and 27 hours after probe placement, subjects received 4.18 MJ meals containing 60% calories from fat or carbohydrate sources. Preprandial and postprandial pressure activity and motor patterns were evaluated. Results-Both meals induced phasic activity with a greater area under the curve (p<0.03) in the first postprandial hour, compared with the control period. Fat induced motor activity persisted longer (p<0.05) than that of the carbohydrate meal, but the onset of motor response was slower (p<0.001). Although both meals induced more (p<0.001) propagating pressure waves, only the fat meal induced more (p<0.05) simultaneous and retrograde waves. After both meals, 50% of subjects exhibited high amplitude (more than 103 mm Hg), prolonged duration (more than 13 seconds) propagating waves. Both meals induced greater activity (p<0.05) in the transverse/descending colon than in the rectosigmoid colon. Conclusions-Carbohydrate meals induce colonic motor response, but the eVects are short lived when compared with fat meals. The prolonged, segmental, and retrograde phasic activity induced by the fat meal may delay colon transit. Thus meal composition influences colonic motor response.

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Section: Discussionmentioning

confidence: 99%

Effects of fat and carbohydrate meals on colonic motor response

Rao

2000

Gut

101

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“…PYY was measured in plasma by a sensitive and specific radioimmunoassay [35, 36]. The detection limit of the assay was obtained at a final concentration in the incubation mixture of 0.3 p M PYY and the ID 50 at 1.7 p M .…”

Section: Methodsmentioning

confidence: 99%

Plasma Cholecystokinin, Plasma Peptide YY and Gallbladder Motility in Patients with Slow Transit Constipation: Effect of Intestinal Stimulation

Mollen

Hopman²,

Kuijpers³

et al. 2000

Digestion

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Background/Aim: Because cholecystokinin and peptide YY are gut hormones with potent effects on gastrointestinal motility, we determined whether abnormalities of cholecystokinin and peptide YY exist in slow transit constipation. Methods: Plasma concentrations of these hormones before, during and after intraduodenal infusion of a liquid meal in 21 patients with slow transit constipation were compared with the results in 8 healthy controls. Results: Fasting levels of plasma cholecystokinin (3.1 ± 0.2 vs. 2.4 ± 0.2 pM; p = 0.02) were higher in patients. Basal plasma peptide YY (11.4 ± 1.4 vs. 8.9 ± 0.7 pM; p = 0.1) tended to be higher in patients. After the meal (60–90 min), incremental cholecystokinin (p < 0.05), but not peptide YY, was significantly higher in patients. During intraduodenal infusion of the meal (0–60 min), incremental plasma cholecystokinin (251 ± 20 pM·min) and peptide YY (1,146 ± 186 pM·min) in patients were almost similar to control values (262 ± 22 and 901 ± 166 pM·min). Gallbladder volumes before, during and after the meal were not different between the 2 groups. Gastric emptying of a solid meal was delayed in the majority of patients (12 of 18). Abnormalities of plasma cholecystokinin were observed only in patients with delayed gastric emptying. Conclusion: Plasma levels of cholecystokinin are elevated in the fasting state and decrease more slowly after stimulation, but maximum release in response to intestinal nutrients is not altered in patients with slow transit constipation. The abnormality seems to be confined to a subgroup of patients with delayed gastric emptying.

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“…In a previous study we found a strong correlation between increments of PYY in plasma and inhibition of gastrinstimulated gastric acid secretion by intraduodenal administration of dietary fat (17). The aim of this study was to further establish the role of circulating PYY in the inhibition of gastrin-stimulated gastric acid secretion by dietary fat.…”

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confidence: 86%

“…The amount of acid secreted (mmol/15 min) was calculated as follows: (acid concentration measured Á V A )/recovery. PYY and gastrin concentrations in plasma were measured with sensitive and specific radioimmunoassays as previously described (17,21). Study 2.…”

Section: Subjectsmentioning

confidence: 99%

“…After 30 min of unstimulated conditions intravenous gastrin-17 infusion was started and continued for 3 h. PYY was infused at a dose of 10 pmol/kg Á h in the 2nd h and at a dose of 20 pmol/kg Á h in the final hour. These doses produce increases in plasma PYY concentrations in the same range as observed after intraduodenal administration of fat (17). In the control test saline was infused continuously for the last 3 h. Blood samples were obtained at À15, 0, 45, 60, 90, 105, 120, 150, 165, and 180 min.…”

Section: Subjectsmentioning

confidence: 99%

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Role of Circulating Peptide YY in the Inhibition of Gastric Acid Secretion by Dietary Fat in Humans

Hoentjen

Hopman²,

Maas³

et al. 2000

Scandinavian Journal of Gastroenterology

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Release of peptide YY and inhibition of gastric acid secretion by long‐chain and medium‐chain triglycerides but not by sucrose polyester in men

Abstract: We speculate that peptide YY may play an important role in the inhibition of gastrin-stimulated gastric acid secretion by long-chain and medium-chain triglycerides.

Cited by 35 publications

References 59 publications

Effects of fat and carbohydrate meals on colonic motor response

Effects of fat and carbohydrate meals on colonic motor response

Plasma Cholecystokinin, Plasma Peptide YY and Gallbladder Motility in Patients with Slow Transit Constipation: Effect of Intestinal Stimulation

Role of Circulating Peptide YY in the Inhibition of Gastric Acid Secretion by Dietary Fat in Humans

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