Release of pro-coagulant microparticles after moderate endurance exercise

Soßdorf, Maik; Otto, Gordon P.; Claus, Ralf A.; Gabriel, Holger; Lösche, Wolfgang

doi:10.3109/09537101003698564

Cited by 17 publications

(35 citation statements)

References 18 publications

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“…The time course for release of MVs into the circulation is similar to those observed with other triggers. For example, moderate exercise for 90 min has been shown to lead to an immediate increase in platelet-derived MVs [86] in healthy males. In addition, moderate exercise causes an increase in endothelial-cell-and monocyte-derived MVs in highly trained healthy individuals [87].…”

Section: Exercise and Cardiovascular Stressmentioning

confidence: 99%

Section: Rate Of Clearance From the Circulationmentioning

confidence: 99%

“…Sossdorf et al [86,87] carried out two studies using moderate endurance exercise as a model for excess MV generation in vivo. They found that, in physically untrained individuals, platelet MVs remained elevated in the circulation (even continuing to rise) up to 2 h following exercise [86,87]. Supporting this, Chaar et al [91] also noted that elevated platelet-and neutrophil-derived MVs remained elevated 2 h following maximal exercise in healthy males, whereas in trained individuals, exercise-elevated platelet MVs returned to baseline within 2 h [87] and high-intensity training in triathletes/cyclists led to a fall in CD31 + CD42 − endothelial MVs below baseline within 1 h [113].…”

Section: Rate Of Clearance From the Circulationmentioning

confidence: 99%

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Dynamic microvesicle release and clearance within the cardiovascular system: triggers and mechanisms

et al. 2015

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Interest in cell-derived microvesicles (or microparticles) within cardiovascular diagnostics and therapeutics is rapidly growing. Microvesicles are often measured in the circulation at a single time point. However, it is becoming clear that microvesicle levels both increase and decrease rapidly in response to certain stimuli such as hypoxia, acute cardiac stress, shear stress, hypertriglyceridaemia and inflammation. Consequently, the levels of circulating microvesicles will reflect the balance between dynamic mechanisms for release and clearance. The present review describes the range of triggers currently known to lead to microvesicle release from different cellular origins into the circulation. Specifically, the published data are used to summarize the dynamic impact of these triggers on the degree and rate of microvesicle release. Secondly, a summary of the current understanding of microvesicle clearance via different cellular systems, including the endothelial cell and macrophage, is presented, based on reported studies of clearance in experimental models and clinical scenarios, such as transfusion or cardiac stress. Together, this information can be used to provide insights into potential underlying biological mechanisms that might explain the increases or decreases in circulating microvesicle levels that have been reported and help to design future clinical studies.

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Section: Exercise and Cardiovascular Stressmentioning

confidence: 99%

Section: Rate Of Clearance From the Circulationmentioning

confidence: 99%

Section: Rate Of Clearance From the Circulationmentioning

confidence: 99%

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Dynamic microvesicle release and clearance within the cardiovascular system: triggers and mechanisms

et al. 2015

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“…inflammation, reactive oxygen species, hypoxia) have been shown to alter circulating MPs, but the extent to which these factors contribute to the rate of MP shedding or clearance is not completely understood (Ayers et al., ; Curtis et al., ; Dignat‐George & Boulanger, ; Hoyer et al., ). Generally, results have varied with regard to the magnitude and direction of exercise‐induced changes in MP concentrations, probably owing to the diversity among exercise protocols (Durrer et al., ; Guiraud et al., ; Lansford et al., ; Mobius‐Winkler et al., ; Serviente et al., ; Sossdorf, Otto, Claus, Gabriel, & Lösche, , ; Wilhelm, Gonzalez‐Alonso, Parris, & Rakobowchuk, ). As previous investigations have used a variety of exercise protocols, it seems plausible that exercise mode, intensity and duration all influence the degree of variation in MP concentrations (Durrer et al., ; Guiraud et al., ; Lansford et al., ; Mobius‐Winkler et al., ; Serviente et al., ; Sossdorf et al., , ; Wilhelm et al., ).…”

Section: Introductionmentioning

confidence: 99%

Effect of exercise intensity on circulating microparticles in men and women

Shill

Lansford

Hempel

et al. 2018

Experimental Physiology

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Circulating microparticles (MPs) are biological vectors of information within the cardiovascular system that elicit both deleterious and beneficial effects on the vasculature. Acute exercise has been shown to alter MP concentrations, probably through a shear stress-dependent mechanism, but evidence is limited. Therefore, we investigated the effect of exercise intensity on plasma levels of CD34 and CD62E MPs in young, healthy men and women. Blood samples were collected before, during and after two energy-matched bouts of acute treadmill exercise: interval exercise (10 × 1 min intervals at ∼95% of maximal oxygen uptake V̇O2max) and continuous exercise (65% V̇O2max). Continuous exercise, but not interval exercise, reduced CD62E MP concentrations in men and women by 18% immediately after exercise (from 914.5 ± 589.6 to 754.4 ± 390.5 MPs μl ; P < 0.05), suggesting that mechanisms underlying exercise-induced CD62E MP dynamics are intensity dependent. Furthermore, continuous exercise reduced CD62E MPs in women by 19% (from 1030.6 ± 688.1 to 829.9 ± 435.4 MPs μl ; P < 0.05), but not in men. Although interval exercise did not alter CD62E MPs per se, the concentrations after interval exercise were higher than those observed after continuous exercise (P < 0.05). Conversely, CD34 MPs did not fluctuate in response to short-duration acute continuous or interval exercise in men or women. Our results suggest that exercise-induced MP alterations are intensity dependent and sex specific and impact MP populations differentially.

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“…Recently, we have demonstrated that moderate endurance exercise increased the number of circulating platelet-derived MP (PMP) and enhanced the plasma procoagulant potential in healthy male volunteers (34). Physical inactivity is an established risk factor of morbidity and mortality (3).…”

mentioning

confidence: 99%