Release of Prostaglandin F-2  During Foaling in Mares

Sharma, O. P.

doi:10.1530/jrf.0.0450541

Cited by 2 publications

(2 citation statements)

References 8 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Prostaglandins are also important in the processes of labour in the mare. Levels of prostaglandin F20 (Sharma 1975;Silver el al 1979) and the major circulating metabolite of prostaglandin Fl0, 13, 14-dihydro-15-oxo-PGF-2a (PGFM) (Barnes et al 1978;Silver et al1979;Pashen and Allen 1979) increase in the maternal circulation in the last weeks of pregnancy and during labour, and the synthetic prostaglandin F analogue, Complele delivery 6or 1 "I fluprostenol, induces parturition at term (Rossdale, Pashen and Jeffcott 1979).…”

Section: Parturitionmentioning

confidence: 99%

Maternal and foetal endocrinology during late pregnancy and parturition in the mare

Pashen

1984

Equine Veterinary Journal

View full text Add to dashboard Cite

Section: Parturitionmentioning

confidence: 99%

Maternal and foetal endocrinology during late pregnancy and parturition in the mare

Pashen

1984

Equine Veterinary Journal

View full text Add to dashboard Cite

“…The circulating PG concentration in mares is determined generally by measurement of 15-keto-dihydro PGF2α (PGFM) [2,8,16]. The PGFM concentration, which is PG and its metabolic product, rises during the last stage of pregnancy or at the time of delivery [2,8,16,18,20,21]. According to detailed observations throughout delivery, the rise in PGFM concentration starts from the 1st stage of delivery, rises rapidly at the 2nd stage of delivery and peaks just before discharge of the foal [15] or simultaneously with discharge of the foal [8].…”

mentioning

confidence: 99%

Relationship between Peripartal Plasma Oxytocin and Prostaglandin F2.ALPHA. Metabolite and Placental Expulsion Time in Heavy Draft Mares

Ishii

Kobayashi

Acosta

et al. 2008

Journal of Reproduction and Development

View full text Add to dashboard Cite

Abstract. The aim of this study was to clarify the relationship between circulating oxytocin (OT) and PGF2α metabolite (PGFM) in mares at the third stage of labor and placental expulsion time in order to investigate a cause of retained placenta of which the incidence increase in a heavy draft mare. Blood was sampled every 5 min from foaling to expulsion of the placenta in 18 heavy draft mares to evaluate circulating OT and PGFM. The relationships between OT and PGFM concentration and recorded placental expulsion times were investigated. The results were as follows (1) The highest level of OT concentration was observed close to foaling in 15 mares. (2) The OT concentrations close to foaling were variable with a large difference from the lowest concentration, 22.1 pg/ml, to the highest concentration, 209.3 pg/ ml. (3) The highest level of PGFM was observed close to foaling in 17 mares. (4) During the 60 min following foaling, the OT concentrations of the mares (n=11) that had a shorter placental expulsion time (i.e., <1 h), were significantly higher than those of the mares (n=7) that had a longer placental expulsion time (i.e., >1 h; P<0.05). Collectively, the OT concentration immediately after foaling is negatively related to the placental expulsion time. Deficiency of OT secretion at foaling have should be considered as one of the causes of retained placenta in heavy draft mares. Key words: Heavy draft mare, Oxytocin, 15-keto-dihydro prostaglandin F2α (PGFM), Placental expulsion (J. Reprod. Dev. 54: [270][271][272][273][274] 2008) ecently, the heavy draft horses of Japan have increased in size and become one of the largest breeds in the world. Retained placenta is occurring more frequently in heavy draft mares due to corpulence with lack of exercise because they are not used for work. A prolonged retained placenta in a mare causes a puerperal infectious disease and laminitis, and it may also cause death. Several causes of retained placenta, such as uterine inertia, placentitis, chill stress and hormone imbalance, have been considered [10,17,20]. Extension of the placental expulsion time reduces the subsequent conception rate in mares [9]. Although the conception rate of foaling heat in mares whose placental expulsion time was less than 1 hour was 66%, the conception rate of mares in which the placental expulsion time exceeded 4 h fell to 51.7% [9]. Manual removal of the placenta led to a decrease in subsequent fertility [9]. The level of circulating oxytocin (OT) rises rapidly in the 2nd stage of delivery in mares [1,8, 24]. Moreover, it is known that OT secretion helps discharge milk from the mammary glands [5,21]. Prostaglandin F2α (PG) might play a role in contraction of the myometrium at delivery. The circulating PG concentration in mares is determined generally by measurement of 15-keto-dihydro PGF2α (PGFM) [2,8,16]. The PGFM concentration, which is PG and its metabolic product, rises during the last stage of pregnancy or at the time of delivery [2,8,16,18,20,21]. According to detailed observations throu...

show abstract

Release of Prostaglandin F-2 During Foaling in Mares

Cited by 2 publications

References 8 publications

Maternal and foetal endocrinology during late pregnancy and parturition in the mare

Maternal and foetal endocrinology during late pregnancy and parturition in the mare

Relationship between Peripartal Plasma Oxytocin and Prostaglandin F2.ALPHA. Metabolite and Placental Expulsion Time in Heavy Draft Mares

Contact Info

Product

Resources

About