Release of prostaglandin-like material from dog kidney during nerve stimulation

Dunham, Earl W; Zimmerman, Ben G.

doi:10.1152/ajplegacy.1970.219.5.1279

Cited by 141 publications

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“…The administration of angiotensin II and noradrenaline produced increases in perfusion pressure and in the basal output of prostaglandin-like material from the perfused kidney, thus confirming previous observations by Dunham & Zimmerman (1970).…”

Section: Discussionsupporting

confidence: 89%

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Release of Prostaglandins From the Rabbit Perfused Kidney: Effects of Vasoconstrictors

Gagnon

Gauthier

Regoli

1974

British J Pharmacology

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1The rat stomach strip was used to assay prostaglandin E2 -like material released by a rabbit isolated kidney perfused with Krebs solution. 2 Doses of noradrenaline and angiotensin II producing similar vasoconstrictor effects released equivalent amounts of prostaglandins from the kidney. 3 8-Leu-angiotensin II, a specific inhibitor of the natural octapeptide, blocked the action of angiotensin II on perfusion pressure and the release of prostaglandins, while the action of noradrenaline on both parameters was unaffected. 4 Indomethacin, a specific inhibitor of prostaglandin biosynthesis, blocked the effects of both vasoconstrictors on prostaglandin release while their action on perfusion pressure was significantly enhanced. 5 In the kidney effluent, amounts of prostaglandin E2-like material increased linearly with the rise in perfusion pressure induced by increasing doses of angiotensin II. These results indicate that prostaglandin output from the isolated kidney follows the rise in perfusion pressure.

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Section: Discussionsupporting

confidence: 89%

“…As previously demonstrated by Dunham & Zimmerman (1970), prostaglandin-like material is released from the dog kidney during an increase in renal vascular resistance. Furthermore, in the dog, McGiff et al (1970) observed a correlation between the rise in renal vascular resistance and the dose of angiotensin II.…”

Section: Discussionsupporting

confidence: 55%

Release of Prostaglandins From the Rabbit Perfused Kidney: Effects of Vasoconstrictors

Gagnon

Gauthier

Regoli

1974

British J Pharmacology

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“…11 However, the mechanisms underlying the TxA 2 increase remain to be elucidated. Among them, the sympathetic nervous system could be of major importance since 1) intrarenal administration of norepinephrine (NE) and of phenylephrine (PHE) 12 - 13 or electrical renal nerve stimulation 14 is followed by an increase in prostaglandin synthesis and 2) the in vivo turnover of norepinephrine is increased in the kidney cortex of 5-week-old LH rats. 15 Therefore, the present study was undertaken to determine the influence of adrenergic stimulation on the renal production of TxA 2 in LH rats.…”

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confidence: 99%

Adrenergic stimulation of renal prostanoids in the Lyon hypertensive rat.

et al. 1991

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Young, genetically hypertensive Lyon (LH) rats exhibited an increased renal in vivo turnover of norepinephrine and an elevated urinary excretion of thromboxane B 2 when compared with nonnotensive (LN) and low blood pressure (LL) controls. Therefore, the effects of norepinephrine (1.2 xlO" 8 to 9.6 xlO" 7 M) and of phenylephrine (5xlO~8 to 1.9x10"' M) on renal function and the urinary excretion of prostanoids were assessed in isolated perfused kidneys of 8-week-old LH, LN, and LL rats. In addition, the effects of norepinephrine were assessed before and during thromboxane A 2 /prostaglandin H 2 receptor blockade by AH23848 (4xlO~* M). Before drug infusion, LH kidneys differed from those of LN and LL controls by having an elevated renal vascular resistance and a decreased natriuresis and glomerular filtration rate; the urinary output of prostaglandin E 2 and F^, of 6-ketoprostaglandin F la , and of thromboxane B 2 was similar in the three strains. The constrictor effects of norepinephrine and phenylephrine were significantly increased in LH rat kidneys compared with LL but not with LN controls, and their pressure-natriuresis was markedly reduced. Norepinephrine and phenylephrine induced a 10-to 20-fold dose-dependent increase in the synthesis of the four prostanoids, which was more pronounced in LH than in LN and LL rats for thromboxane B 2 only. AH23848 infusion significantly reduced the vascular effects of norepinephrine and increased the natriuretic response of LH but not of LN and LL rat kidneys. In conclusion, isolated perfused kidneys from LH rats exhibit an increased production of thromboxane A 2 , which enhances the renal effects of norepinephrine and therefore could participate in the development of hypertension of the Lyon model. (Hypertension 1991;17:296-302)

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“…, , 1971Sam uelsson and Wennmalm, 1971;Frame and Hedqvist, 1975). Second, sympathetic nerve stimulation re leases a prostaglandin-like substance into the splenic and renal venous effluents (Ferreira and Vane, 1967;Dunham and Zimmerman, 1970). Third, the inhibi tion of prostaglandin synthesis augments vasocon striction during sympathetic nerve stimulation in spleen and kidney (Ferreira and Moncada, 1971;Malik and McGiff, 1975;Oliver et aI., 1981).…”

Section: Discussionmentioning

confidence: 99%

Role of Prostaglandins in Modulating Sympathetic Vasoconstriction in the Cerebral Circulation in Anesthetized Rabbits

Busija

1985

J Cereb Blood Flow Metab

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Summary:The effects of the interaction between sym pathetic nerves and prostaglandins in the cerebral circu lation were examined, The hypothesis tested was that inhibition of prostaglandin synthesis by indomethacin would potentiate decreases in CBF caused by sympa thetic nerve stimulation, In anesthetized rabbits, fol lowing administration of either indomethacin (10 mg/kg) or vehicle, CBF was measured with 15 -f.Lm microspheres prior to stimulation and following 3-5 min of electrical stimulation (4, 8, 16 Hz) of both superior cervical ganglia, In the vehicle group, CBF was 33-42 mIlmin/100 g prior to stimulation, Bilateral sympathetic stimulation reduced blood flow to the cerebrum by 12 ± 6% (mean ± SEM ) (p < 0,05 ) at 4 Hz (n = 8), by 20 ± 4% (p < 0,05 ) at 8 Hz (n = 12), and 21 ± 6% (p < 0,05 ) at 16 Hz (n = 11), In the indomethacin group, CBF was 37-48 mIlmin/100Prostaglandins and related compounds are syn thesized by cerebral arteries and have vasoactive effects (Ellis et aI., 1979; Abdel-Halim et aI., 1980). However, their importance in the regulation of CBF during physiological conditions is unclear. Although prostaglandins have been reported to participate di rectly in the maintenance of resting CBF and in cerebral vasodilatation during hypercapnia in rats and baboons (Pickard and MacKenzie, 1973; Dahl gren et aI. , 1981), recent studies were unable to con firm their involvement in these responses in rabbits, cats, and dogs (Wei et aI., 1980; Busija, 1983a;Busija and Heistad, 1983; Jackson et aI. , 1983 lation. Cerebral arteries are supplied richly by sym pathetic nerves (Nelson and Rennels, 1970;Peerless and Yasargil, 1978), and prostaglandins released near nerve endings during activation of sympathetic nerves could modulate cerebral vasoconstriction. Prostaglandins are synthesized and released by or near nerve endings during activation of sympathetic nerves, and appear to attenuate vasoconstrictor re sponses in several organs. For example, the blockade of prostaglandin synthesis by cyclooxy genase inhibitors results in augmented vasocon strictor responses during sympathetic nerve stimu lation in kidney and spleen (Ferreira and Moncada, 1971;Malik and McGiff, 1975; Oliver et aI., 1981). Only one previous study has examined this rela tionship in the cerebral circulation, and the results are paradoxical. Beausang-Linder (1982) reports that indomethacin, rather than augmenting re sponses, blocked decreases in CBF during sympa thetic nerve stimulation in rabbits. Limitations of that study were that sympathetic nerves were stim-

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Release of prostaglandin-like material from dog kidney during nerve stimulation

Cited by 141 publications

References 0 publications

Release of Prostaglandins From the Rabbit Perfused Kidney: Effects of Vasoconstrictors

Release of Prostaglandins From the Rabbit Perfused Kidney: Effects of Vasoconstrictors

Adrenergic stimulation of renal prostanoids in the Lyon hypertensive rat.

Role of Prostaglandins in Modulating Sympathetic Vasoconstriction in the Cerebral Circulation in Anesthetized Rabbits

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