Release of recombinant human bone morphogenetic protein-2 from heterocyclic methacrylate polymer systems

Patel, Mukesh R.; Pavlovič, P.; Hughes, Francis J.; King, Gaston N.; Cruchley, A. T.; Braden, M.

doi:10.1016/s0142-9612(00)00396-3

Cited by 17 publications

(20 citation statements)

References 25 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Superabsorbent polymers are loosely cross-linked polyelectrolyte hydrogel networks which can absorb water up to several hundred times their dried weights and retain water under pressure, which have been widely used in many fields such as medicine for drugdelivery systems, 1 tissue engineering, 2 immobilization of protein and cells, 3 agriculture and horticulture, 4 sanitary products, 5 and so on. Their superior swelling abilities are well known to originate from the electrostatic repulsion between the charges on the polymer chains and the osmotic imbalance between the interior and exterior of the hydrogel networks.…”

Section: Introductionmentioning

confidence: 99%

“…8,9 As mentioned above, superabsorbent polymers have found useful applications in many fields such as drug-delivery systems, 1 tissue engineering 2 or biomaterials. 3 In these cases, the external environment of a superabsorbent polymer mostly contains salt aqueous solutions and thus the pure polyelectrolyte superabsorbents often lose their swelling performance due to the collapse of the network. From this point of view, incorporation of GO nanoplatelets into polyelectrolyte superabsorbents networks, in this case PAA, should be an efficient method for enhancement of the salt-resistance of a superabsorbent and may be especially useful in these mentioned biological applications.…”

mentioning

confidence: 99%

See 1 more Smart Citation

Preparation of poly(acrylic acid)–graphite oxide superabsorbent nanocomposites

et al. 2012

View full text Add to dashboard Cite

Graphite oxide (GO) nanoplatelets with a thickness from 0.8 nm to 2 nm were prepared using a modified Hummers method. By employing GO nanoplatelets as nanofillers, poly(acrylic acid)-GO superabsorbent nanocomposites were synthesized by a facile solution polymerization of acrylic acid monomers using N,N 0 -methylenebisacrylamide as cross-linker and ammonium persulfate as initiator.The well-dispersed GO nanoplatelets in the polymer networks results in a significant improvement in absorbencies both in distilled water and saline solutions. With only a very low loading of GO in the superabsorbent nanocomposite, for example 0.073 wt%, its water absorbency reaches up to 508 g g À1 , which is nearly as twice that of the poly(acrylic acid) (PAA) superabsorbent. The superabsorbent nanocomposite also exhibits a superior water-retention ability compared with the control under the same conditions. Our study may provide a new way for the development of novel, GO-based superabsorbent nanocomposites with improved absorbency and may find a variety of useful applications.

show abstract

Section: Introductionmentioning

confidence: 99%

mentioning

confidence: 99%

Preparation of poly(acrylic acid)–graphite oxide superabsorbent nanocomposites

et al. 2012

View full text Add to dashboard Cite

show abstract

“…collagen [26], porous hydroxyapatite scaffolds [53] or polymeric systems such as poly-(lactide-co-glycolic acid), methacrylate systems [55] and a thermoreversible polymer [23] with protein binding possibility have been studied for bone tissue engineering applications. Few studies exist in which BMPs are covalently bound to the metal implant surface for orthopedic or dental implants [29,56].…”

Section: Methods Of Implant Surface Coating With Bmp-2mentioning

confidence: 99%

“…Other authors established a periprosthetic acetabular model in dogs with a defined 2 mm defect [55,61]. In this canine hip endoprosthesis model the effect of rhBMP-2 on ingrowth across gap and non-gap regions in a porous acetabular component was tested using a rhBMP-2/alpha-BSM model (alpha bone substitute material).…”

Section: Long Bonementioning

confidence: 99%

Enhancement of endoprosthesis anchoring using BMP-2

Thorey

Menzel

Lorenz

et al. 2010

THC

View full text Add to dashboard Cite

Osseointegration of long-term implants is still a problem in orthopaedic surgery. In recent years, several techniques to modify the implant surface to increase bone formation around implants have been described by many authors. Most endoprostheses used in orthopaedic surgery are manufactured from titanium. To understand the process of osseointegration, one has to take into account, that the adhesion of plasma proteins on the surface of titanium implants plays an essential role in the process of implant integration. In the last years, several modifications of implant surfaces (structure, chemistry, surface charge, wettability) have been investigated to improve osseointegration of titanium implants. Furthermore, several cytokines and growth factors have also been suggested to stimulate an implant ingrowth. In this respect, functionalized titanium implant surfaces with bone morphogenetic proteins-2 (BMP-2) as one particular member of the superfamily of transforming growth factor β (TGF-β), have proven a potential to stimulate bone formation around implants in different species. In this review the authors provide an overview of surface coatings with BMP-2 and their use in laboratory and experimental settings. F. Thorey et al. / Enhancement of endoprosthesis anchoring using BMP-277]. In the last years, several modifications of implant surfaces (structure, chemistry, surface charge, wettability) have been investigated to improve osseointegration of titanium implants [4]. Furthermore, several cytokines and growth factors have also been suggested to stimulate an implant ingrowth [73,83]. The functionalization of implant surfaces with bone morphogenetic proteins (BMP), as one particular growth factor, has proven a potential to stimulate bone formation both in extraskeletal sites [86,88] and in defect models in different species [69,89].As multi-functional growth factors, BMP's belong to the superfamily of transforming growth factor β (TGFβ). Urist et al. first identified the activity of BMPs in the 1960s [72], but the proteins responsible for bone induction remained unknown. Further investigations were made in the late 1980s by Wozney et al., who purified and sequenced bovine BMP-3 (osteogenin) and cloned human 82]. So far, about 20 BMP family members have been identified and characterized. BMPs signal through serine/threonine kinase receptors, type I and type II. Several type I and type II receptors have been described to bind BMP ligands: three type I receptors (BMPR-IA or ALK-3, BMPR-IB or ALK-6, and type IA activin receptor ActR-IA or ALK-2) [37,47,70] and three type II receptors (type II BMP receptor (BMPR-II) and type II and IIB activin receptors (ActR-II and ActR-IIB) [36,58,85]). Whereas BMPR-IA, IB and II are specific to BMPs ActR-IA, II and IIB are also signaling receptors for activins. All these receptors are expressed differentially in diverse tissues. Type I and II BMP receptors are both indispensable for signal transduction. A heterotetrameric-activated receptor complex is formed after ligand binding. This c...

show abstract

“…For this reason, it is possible to synthesize hydrogels that can be used to immobilize a great variety of compounds: drugs (Tae-Wan et al, 2003;He et al, 2004), proteins (Baptista et al, 2003;Patel et al, 2001) or even cells (Horák et al, 2004). In this way, different systems with different applications can be obtained.…”

Section: Introductionmentioning

confidence: 99%