Release pattern of cardiac biomarkers in left ventricular apical ballooning

Nef, Holger; Möllmann, Helge; Weber, Michael; Deetjen, Anja; Brandt, Roland R.; Hamm, Christian W.; Elsässer, Albrecht

doi:10.1016/j.ijcard.2006.01.034

Cited by 26 publications

(25 citation statements)

References 3 publications

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“…The secretion pattern of BNP in takotsubo patients is quite similar to that in myocardial infarction patients, and 1 report presented the precise time course of BNP secretion in patients with takotsubo cardiomyopathy. 16 Basal hyperkinesia might be related with left ventricular end-diastolic pressure and BNP release. 17 Cardiac enzyme levels (eg, creatinine kinase, troponin T) are slightly increased.…”

Section: Clinical Featuresmentioning

confidence: 99%

“…15 In addition, ischemic myocardial stunning does not produce the histological changes usually observed in takotsubo cardiomyopathy. 16 Finally, spontaneous or inducible coronary arterial spasm has not been found in most cases of takotsubo cardiomyopathy. Accordingly, myocardial stunning resulting from epicardial coronary artery spasm does not seem to cause takotsubo cardiomyopathy.…”

Section: Concepts About Pathophysiologymentioning

confidence: 99%

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Takotsubo Cardiomyopathy

et al. 2008

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Section: Clinical Featuresmentioning

confidence: 99%

Section: Concepts About Pathophysiologymentioning

confidence: 99%

Takotsubo Cardiomyopathy

et al. 2008

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“…The authors speculated that the ‘missing link’ in pathogenesis of takotsubo cardiomyopathy might be explained by paraneoplastic phenomena. A few prognostic techniques including ECG findings, thrombolysis in myocardial infarction myocardial perfusion grade and N-terminal fragment of B-type natriuretic peptide (NT-proBNP) have been investigated; however, no clear markers of outcome were identified 17 80 81…”

Section: Clinical Featuresmentioning

confidence: 99%

Takotsubo cardiomyopathy: pathophysiology and treatment

Milinis

Fisher

2012

Postgraduate Medical Journal

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Since it was first described 20 years ago in Japan, takotsubo cardiomyopathy has received considerable interest from the medical community around the world, particularly in recent years. Although takotsubo cardiomyopathy was originally described as a transient, stress-induced dysfunction of the left ventricular apex, other morphological subtypes have now been described. The pathogenesis of this disorder is likely to be catecholamine mediated myocyte damage and microvascular dysfunction; however, a number of possible alternative theories have been suggested. These include oxidative stress, transient coronary obstruction and oestrogen deficiency, the last explaining the high prevalence of takotsubo cardiomyopathy in women. The treatment remains largely supportive; however, a number of agents have been implicated in the acute stage and long term. Although most of the patients show complete recovery, there is a high risk of complications at the initial presentation requiring intense support.

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“…Nef et al 77 suggested that the serum concentrations of the N-terminal fragment of B-type natriuretic peptide (NT-proBNP) may be valuable prognostic marker for the assessment of myocardial deterioration and recovery. Inevitably low values at admission indicated a good prognosis 77…”

Section: Prognosismentioning

confidence: 99%

Takotsubo cardiomyopathy: a diagnostic challenge

Zeb

Sambu

Scott

et al. 2010

Postgraduate Medical Journal

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The frequency of the diagnosis of takotsubo cardiomyopathy has increased rapidly over the past few years, possibly due to increasing awareness among cardiologists. At initial presentation the diagnosis remains a challenge because of the close similarity between the presentation of takotsubo cardiomyopathy, and that of ST elevation myocardial infarction (STEMI). Recognition of salient aspects of the medical history at presentation are important in order to organise further appropriate investigations such as echocardiography and left ventriculography at the time of coronary angiogram. Takotsubo cardiomyopathy can be easily missed without ventriculography early after presentation because of the transient nature of left ventricular dysfunction, and in many centres left ventriculogram is not done as standard in the setting of STEMI. The authors advocate left ventriculography in all cases of ST elevation who have unobstructed coronaries. The correct diagnosis of takotsubo cardiomyopathy is very important for future advice and management of the patient. The prognosis of this condition is generally excellent with almost all patients returning to normal within a few weeks. This article examines the takotsubo cardiomyopathy literature and discusses the pathophysiology, clinical features, management, and prognosis of this condition in the context of an illustrated case.

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Release pattern of cardiac biomarkers in left ventricular apical ballooning

Cited by 26 publications

References 3 publications

Takotsubo Cardiomyopathy

Takotsubo Cardiomyopathy

Takotsubo cardiomyopathy: pathophysiology and treatment

Takotsubo cardiomyopathy: a diagnostic challenge

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