2014
DOI: 10.1371/journal.pone.0092393
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Release Retardation of Model Protein on Polyelectrolyte-Coated PLGA Nano- and Microparticles

Abstract: PEM capsules have been proposed for vehicles of drug microencapsulation, with the release triggered by pH, salt, magnetic field, or light. When built on another carrier encapsulating drugs, such as nanoparticles, it could provide additional release barrier to the releasing drug, providing further control to drug release. Although liposomes have received considerable attention with PEM coating for sustained drug release, similar results employing PEM built on poly(lactic-co-lycolic acid) (PLGA) particles is sca… Show more

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Cited by 7 publications
(3 citation statements)
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“…At lower pH, swelling of PAH/PSS films happen due to variation in the charge density of polyelectrolyte chains which induce the electrostatic repulsion between PAH/PSS multilayers and thus facilitating drug release (Scheme S1). The mechanism of release has been studied in the previous reports [41,42] . As the drug release from polymer capsules is higher at acidic pH, more availability of doxorubicin in tumor tissues can be achieved and this can be exploited to improve therapeutic efficacy in vivo.…”
Section: Resultsmentioning
confidence: 99%
“…At lower pH, swelling of PAH/PSS films happen due to variation in the charge density of polyelectrolyte chains which induce the electrostatic repulsion between PAH/PSS multilayers and thus facilitating drug release (Scheme S1). The mechanism of release has been studied in the previous reports [41,42] . As the drug release from polymer capsules is higher at acidic pH, more availability of doxorubicin in tumor tissues can be achieved and this can be exploited to improve therapeutic efficacy in vivo.…”
Section: Resultsmentioning
confidence: 99%
“…Besides, the release of the proteins from microparticles is commonly low and non-uniform. To solve these problems, different excipients have been incorporated during microencapsulation process, as poly(ethylene glycol) (PEG) and sodium chloride (NaCl) (Bock et al, 2014;Buske et al, 2012;Chen et al, 2002;Nugraha et al, 2014;Van de Weert et al, 2000;Ye et al, 2010). These both excipients also improve proteins stability.…”
Section: Introductionmentioning
confidence: 99%
“…Release retardation is observed only at 2 µm particle size. Modified from a Creative-Commons-Attribution licensed article 179.…”
mentioning
confidence: 99%