Release, spread and persistence of immunoreactive neurokinin A in the dorsal horn of the cat following noxious cutaneous stimulation. Studies with antibody microprobes

Duggan, A.W.; Hope, P.J.; Jarrott, B.; Schaible, Hans‐Georg; Fleetwood-Walker, S.M.

doi:10.1016/0306-4522(90)90134-p

Cited by 200 publications

(52 citation statements)

References 26 publications

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“…Using antibody microprobes, a marked release, spread and persistence of immunoreactive neurokinin A were found all over the dorsal horn after noxious cutaneous stimulation by Duggan et al (1990). These results provided strong evidence for long-distance VT in peptide neurons as far as neurokinin A was concerned.…”

Section: Deficits Of Fast Inactivation Mechanisms Of the Transmittermentioning

confidence: 65%

“…In contrast, substance P (SP) remained in the substantia gelatinosa where the SP/neurokinin A IR terminals are concentrated. It seemed likely that the slow degradation of neurokinin A versus SP was responsible for these differential effects on neurokinin A (Duggan et al, 1990). This proposal was elegantly supported by the demonstration that a peptidase inhibitor microinjected into the dorsal horn demonstrated the spread of immunoreactive SP over the entire dorsal horn after noxious cutaneous stimulation .…”

Section: Deficits Of Fast Inactivation Mechanisms Of the Transmittermentioning

confidence: 99%

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From the Golgi–Cajal mapping to the transmitter-based characterization of the neuronal networks leading to two modes of brain communication: Wiring and volume transmission

Fuxé¹,

Dahlström²,

Höistad³

et al. 2007

Brain Research Reviews

234

219

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After Golgi-Cajal mapped neural circuits, the discovery and mapping of the central monoamine neurons opened up for a new understanding of interneuronal communication by indicating that another form of communication exists. For instance, it was found that dopamine may be released as a prolactin inhibitory factor from the median eminence, indicating an alternative mode of dopamine communication in the brain. Subsequently, the analysis of the locus coeruleus noradrenaline neurons demonstrated a novel type of lower brainstem neuron that monosynaptically and globally innervated the entire CNS.Furthermore, the ascending raphe serotonin neuron systems were found to globally innervate the forebrain with few synapses, and where deficits in serotonergic function appeared to play a major role in depression. We propose that serotonin reuptake This will lead to the unified execution of information handling and trophism for optimal brain function and survival.

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Section: Deficits Of Fast Inactivation Mechanisms Of the Transmittermentioning

confidence: 65%

Section: Deficits Of Fast Inactivation Mechanisms Of the Transmittermentioning

confidence: 99%

From the Golgi–Cajal mapping to the transmitter-based characterization of the neuronal networks leading to two modes of brain communication: Wiring and volume transmission

Fuxé¹,

Dahlström²,

Höistad³

et al. 2007

Brain Research Reviews

234

219

View full text Add to dashboard Cite

show abstract

“…This can lead to increased excitability and generation of ectopic discharges [53]. Under these conditions, enhanced activity of primary afferents results in the release of excitatory amino acids and peptides, such as substance P, in the DH, and this increased transmitter release leads to the establishment of central sensitization [11].…”

Section: Introduction Symptomatology and Pathophysiology Of Neuropathmentioning

confidence: 99%

L-Acetylcarnitine: A Proposed Therapeutic Agent for Painful Peripheral Neuropathies

Chiechio¹,

Copani²,

Nicoletti³

et al. 2006

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During the past two decades, many pharmacological strategies have been investigated for the management of painful neuropathies. However, neuropathic pain still remains a clinical challenge. A combination of therapies is often required, but unfortunately in most cases adequate pain relief is not achieved. Recently, attention has been focused on the physiological and pharmacological effects of L-acetylcarnitine in neurological disorders. There are a number of reports indicating that L-acetylcarnitine can be considered as a therapeutic agent in neuropathic disorders including painful peripheral neuropathies. In this review article, we will examine the antinociceptive and the neuroprotective effects of Lacetylcarnitine as tested in clinical studies and in animal models of nerve injury.

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“…Although glutamate is almost certainly the primary mediator of nociceptive transmission at this first synapse, other neurochemicals, notably the tachykinin peptides SP and neurokinin (NK) A, are major contributors (6,7). These peptides are present in a proportion of the small primary afferent neurons that terminate in the outer laminae of the dorsal horn, lamina I and lamina II (8,9); are released by high intensity stimulation (10)(11)(12)(13)(14)(15)(16); enhance the excitability of spinal neurons to noxious inputs (17)(18)(19); and contribute to a 'window' of noxious stimulus-evoked behaviours (20). SP and glutamate colocalize in the terminals of small diameter primary afferent neurons in the dorsal horn (21,22).…”

Section: Pharmacological Controls Of Primarymentioning

confidence: 99%

Presynaptic control of nociceptor signalling: Differential influence of Mu Opioid and GABAergic Systems

Riley

Trafton

Basbaum

2000

Pain Research and Management

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It is difficult to pick a topic to discuss that adequately honours Ron Melzack's many years of pain research. This is particularly problematic if one is cognizant of the tremendous emphasis that Ron puts on the distinction between pain and nociception. Indeed, the thread that binds so many of Ron's studies is that the complexity of the pain experience will not be understood if one exclusively concentrates on the processing of nociceptive messages at the level of the periphery or spinal cord. Ron always emphasized the importance of affective and cognitive components of the pain experience. These elements of the pain experience, so beautifully and memorably discussed in Melzack and Casey's (1) theoretical review, must always be included when this topic is addressed. Dr Allan Basbaum was a student of Ron's in an undergradu- The relative contribution of pre-and postsynaptic controls to the flow of nociceptive information at the level of the spinal cord has been one of Ron Melzack's longstanding interests and a key issue in the formulation of the gate control theory. The authors review their own studies, in which they monitored internalization of the neurokinin-1 receptor to examine specifically the action of two classically inhibitory systems -mu opioid and gamma-amino butyric acid (GABA) -on noxious stimulus-evoked tachykinin signalling in the rat spinal cord. Evidence that opioids and GABAergic controls operate differently on the central consequences of any noxious stimulus-induced substance P release is provided. Whereas at least 80% of the tachykinin signalling remained intact after even the highest concentration of spinal morphine or D-Ala2, NMe-phe4, Glyol5-enkephalin administration, spinal administration of the GABA B receptor agonist baclofen had a dramatic inhibitory effect. These findings are discussed in light of the disappointing clinical utility of baclofen and neurokinin-1 receptor antagonists to combat pain. Key Words: Gamma-amino butyric acid; Mu opioid; Neurokinin 1 receptors; Receptor internalization; Spinal cord; TachykininsCommande présynaptique de la transmission des signaux par les nocicepteurs : mécanisme d'action des opioïdes de type mu et du GABA Le rôle relatif des commandes pré-et postsynaptiques dans la transmission des signaux nociceptifs dans la moelle épinière, en plus de susciter l'intérêt soutenu de Ron Melzack, a constitué un pilier de la théorie du ‹‹ portillon ››. Les auteurs ont passé en revue leurs propres études dans lesquelles ils se sont penchés sur l'endocytose des récep-teurs de la neurokinine 1 afin d'étudier le mécanisme d'action de deux inhibiteurs classiques, les opioïdes de type mu et l'acide gammaaminobutyrique (GABA), sur la transmission de la tachykinine déclen-chée par un stimulus nocif dans la moelle épinière du rat. Ils ont recueilli des preuves selon lesquelles les opioïdes et le GABA agissent différemment sur les effets centraux de la libération de la substance P, provoquée par un stimulus nocif. Tandis qu'au moins 80 % de la transmission des signaux par la tac...

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Release, spread and persistence of immunoreactive neurokinin A in the dorsal horn of the cat following noxious cutaneous stimulation. Studies with antibody microprobes

Cited by 200 publications

References 26 publications

From the Golgi–Cajal mapping to the transmitter-based characterization of the neuronal networks leading to two modes of brain communication: Wiring and volume transmission

From the Golgi–Cajal mapping to the transmitter-based characterization of the neuronal networks leading to two modes of brain communication: Wiring and volume transmission

L-Acetylcarnitine: A Proposed Therapeutic Agent for Painful Peripheral Neuropathies

Presynaptic control of nociceptor signalling: Differential influence of Mu Opioid and GABAergic Systems

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