Released dsDNA‐triggered inflammasomes serve as intestinal radioprotective targets

Abstract

Objectives. Intestinal mucositis is the major side effect during abdominal or pelvic radiotherapy, but the underlying immunogen remains to be further characterised and few radioprotective agents are available. This study investigated the role of dsDNAtriggered inflammasomes in intestinal mucositis during radiotherapy. Methods. Pro-inflammatory cytokines were detected by ELISA. Radiation-induced intestinal injury in mice was analyzed by means of survival curves, body weight, HE staining of