Releasing profile of antibiotics from a novel mineralized collagen putty with quantifiable drug loading

Abstract

2015) Releasing profile of antibiotics from a novel mineralized collagen putty with quantifiable drug loading, Materials Technology, 30:sup8, B216-B222,This study aims to compare the release profile of antibiotics when loaded onto a new mineralized collagen (MC) putty with conventional polymethyl methacrylate (PMMA) cement as well as their feasibility for clinical application for orthopaedic wounds. Two types of antibiotic-loaded implants were fabricated by physically mixing Imipenem or Vancomycin with either PMMA or MC in a quantifiable manner. Subsequently, the release profiles of antibiotics and their inhibitory effects on bacterial growth were evaluated both in vitro and in vivo. In comparison to PMMA, the antibioticloaded MC putty was easier to make with high flexibility of antibiotic selection based on drug sensitivity test, and surgeon friendly moldability. The inhibitory effects of bacterial growth lasted 24 h post-intramuscular implantation. The Imipenem-loaded MC putty was confirmed to be superior as a local drug delivery system (LDDS) over PMMA cement, the only type of antibiotics carrier orthopaedic clinics currently use.

Clinical observation of biomimetic mineralized collagen artificial bone putty for bone reconstruction of calcaneus fracture

“…1 ), which provide sufficient space for osteocytes ingrowth and new bone tissue creeping substitution [ 10 ]. Due to the swelling property of the collagen, mineralized collagen could be mixed with water or blood to become a form of putty with good moldability and injectability [ 17 , 18 ]. So, such mineralized collagen putty is suitable for irregular defect filling and repair for calcaneus fracture.…”