Relevance function of microRNA-708 in the pathogenesis of cancer

Sun, Sinan; Hu, Shuang; Shang, Yu-ping; Li, Liang-yun; Zhou, Hong; Chen, Jia-Si; Yang, Jun; Li, Jun; Huang, Qiang; Shen, Chuan-pu; Xu, Tao

doi:10.1016/j.cellsig.2019.109390

Cited by 23 publications

(16 citation statements)

References 117 publications

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“…So far, radiotherapy is still the main treatment for melanoma, and its success rate of effectively controlling local lesions has reached 80% (Pfannenstiel et al, 2019). Despite effective control of local lesions, patients are often prone to metastasis, including metastasis to the brain, ultimately leading to overall treatment failure (Sun et al, 2019). Remarkably, Rai et al confirmed that the expression of RNF2 was related to melanoma progression at mRNA and protein levels.…”

Section: Overview Of Cancermentioning

confidence: 99%

“…For example, its detection source should be relatively easy to obtain, such as urine, as well as it should have high specificity, that is, the difference between cancer patients and normal people should be large. More importantly, its detection value should have relatively high correlation with the pathological characteristics and clinical manifestations of cancer, such as Gleason score, radiosensitivity, etc (Sun et al, 2019). By coincidence, the related research reported that RNF2 expression was significantly associated with invasive depth, recurrence and metastasis, and radiosensitivity of cancer.…”

Section: Overview Of Cancermentioning

confidence: 99%

“…Generally, tumor is formed by abnormal proliferation of tissue cells under the action of physical, chemical, viral, and other carcinogenic factors. Tumors can be classified as benign and malignant according to their different cellular characteristics and different harmfulness to the body (Sun et al, 2019). Cancer is essentially a genetic disease, and mutations in some key genes, such as the oncogene ras and the tumor suppressor gene Rb, contributing to the development of cancer.…”

Section: Overview Of Cancermentioning

confidence: 99%

“…Therefore, cell detachment from the tumor and subsequent spread to distant sites remains the most important cause of high cancer mortality. However, the lack of relatively stable, reliable, detectable biomarkers, or potential therapeutic targets with application value is the main reason for the low cure rate and poor prognosis of cancer (Sun et al, 2019).…”

Section: Introductionmentioning

confidence: 99%

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Emerging role of RNF2 in cancer: From bench to bedside

Yan

Chen

et al. 2021

Journal Cellular Physiology

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RNF2 (also known as ding, Ring1B or Ring2) is a member of the Ring finger protein family, which functions as E3 ubiquitin ligase for monoubiquitination of histone H2A at lysine 119 (H2AK119ub). RNF2 gene is located at the 1q25.3 site of human chromosome and the coding region is composed of 9 exons, encoding 336 amino acids in total. Many studies have demonstrated that overexpressed RNF2 was involved in the pathological progression of multiple cancers and has an impact on their clinical features. For instance, the upregulated expression level of RNF2 is positively correlated with the occurrence and progression of hepatocellular carcinoma, melanoma, prostate cancer, breast cancer, pancreatic cancer, gastric cancer, and bladder urothelial carcinoma, as well as with the radioresistance of lung cancer and chemoresistance of ovarian cancer. This review provides an up‐to‐date perspective on the relationship between RNF2 and several cancers and highlights recent studies on RNF2 regulation. In particular, the relevant cellular signaling pathways and potential clinical value of RNF2 in cancers are also discussed, suggesting its potential as an epigenetic biomarker and therapeutic target for these cancers.

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Section: Overview Of Cancermentioning

confidence: 99%

Section: Overview Of Cancermentioning

confidence: 99%

Section: Overview Of Cancermentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Emerging role of RNF2 in cancer: From bench to bedside

Yan

Chen

et al. 2021

Journal Cellular Physiology

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“…Furthermore, their potential to regulate numerous target genes makes miRNAs a promising tool in the fight against malignancies. For instance, recent reports have indicated that miRNAs can regulate the tumorigenesis, progression and pathogenesis of liver cancer [9][10][11][12]. In particular, Ma S et al found that miRNAs could relieve resistance to TRAIL-induced cell growth inhibition in liver cancer [13].…”

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confidence: 99%

miR-155-5p increases the sensitivity of liver cancer cells to adriamycin by regulating ATG5-mediated autophagy

Qiu

Xia

et al. 2021

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Liver cancer is the sixth most prevalent cancer worldwide and the third leading cause of cancer-related deaths. Adriamycin (ADR) resistance, which often leads to the progression of malignant tumors, is a major treatment obstacle for liver cancer. It has been confirmed that miR-155-5p could reverse drug resistance in human breast cancer. However, the biological function of miR-155-5p in ADR-resistant liver carcinoma (HepG2/ADR) cells remains unclear. miR-155-5p and ATG5 expression was determined by RT-qPCR and western blot. In addition, MTT, flow cytometry, immunofluorescence staining, and western blotting were performed to evaluate the proliferation, apoptosis, and autophagy of liver cancer cells. Finally, the effect of miR-155-5p on the expression of autophagy-related 5 (ATG5) was analyzed by luciferase activity assay, western blot, and RT-qPCR. Our results showed that miR-155-5p was downregulated in HepG2/ADR cells. Increasing the expression of miR-155-5p enhanced the sensitivity of liver carcinoma cells to ADR and promoted apoptosis through inhibition of autophagy in vitro. In addition, the binding site between miR-155-5p and ATG5 was identified, and miR-155-5p could directly regulate ATG5. Finally, ATG5 partially rescued the effect of miR-155-5p on autophagy and the apoptosis of HepG2/ADR cells. In conclusion, our findings showed that miR-155-5p could reverse ADR resistance in liver cancer by targeting ATG5, which may function as a potential target for liver cancer treatment.

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AMPK‐upregulated microRNA‐708 plays as a suppressor of cellular senescence and aging via downregulating disabled‐2 and mTORC1 activation

Zhang,

Gong,

Zhao

et al. 2024

MedComm

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Senescence‐associated microRNAs (SA‐miRNAs) are important molecules for aging regulation. While many aging‐promoting SA‐miRNAs have been identified, confirmed aging‐suppressive SA‐miRNAs are rare, that impeded our full understanding on aging regulation. In this study, we verified that miR‐708 expression is decreased in senescent cells and aged tissues and revealed that miR‐708 overexpression can alleviate cellular senescence and aging performance. About the molecular cascade carrying the aging suppressive action of miR‐708, we unraveled that miR‐708 directly targets the 3′UTR of the disabled 2 (Dab2) gene and inhibits the expression of DAB2. Interestingly, miR‐708‐caused DAB2 downregulation blocks the aberrant mammalian target of rapamycin complex 1 (mTORC1) activation, a driving metabolic event for senescence progression, and restores the impaired autophagy, a downstream event of aberrant mTORC1 activation. We also found that AMP‐activated protein kinase (AMPK) activation can upregulate miR‐708 via the elevation of DICER expression, and miR‐708 inhibitor is able to blunt the antiaging effect of AMPK. In summary, this study characterized miR‐708 as an aging‐suppressive SA‐miRNA for the first time and uncovered a new signaling cascade, in which miR‐708 links the DAB2/mTOR axis and AMPK/DICER axis together. These findings not only demonstrate the potential role of miR‐708 in aging regulation, but also expand the signaling network connecting AMPK and mTORC1.

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Relevance function of microRNA-708 in the pathogenesis of cancer

Cited by 23 publications

References 117 publications

Emerging role of RNF2 in cancer: From bench to bedside

Emerging role of RNF2 in cancer: From bench to bedside

miR-155-5p increases the sensitivity of liver cancer cells to adriamycin by regulating ATG5-mediated autophagy

AMPK‐upregulated microRNA‐708 plays as a suppressor of cellular senescence and aging via downregulating disabled‐2 and mTORC1 activation

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