Relevance of Endothelial Cell-Specific Molecule 1 (Endocan) Plasma Levels for Predicting Pulmonary Infection after Cardiac Surgery in Chronic Kidney Disease Patients: The Endolung Pilot Study

Perrotti, Andréa; Chenevier‐Gobeaux, Camille; Ecarnot, Fiona; Barrucand, Benoit; Lassalle, Philippe; Dorigo, Enrica; Chocron, Sidney

doi:10.1159/000479337

Cited by 9 publications

(10 citation statements)

References 27 publications

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“…To diagnose infection in patients with a particular pathology/condition After cardiac surgery Endocan [92], CD64 [93], pancreatic stone protein [94] After major surgery Peptidoglycan [95], elastase [96], leptin [84], calprotectin [75], a proliferation-inducing ligand [97], α-2 macroglobulin [89], lipopolysaccharide-binding protein [15] COPD Pentraxin 3 [98] Cirrhosis Interleukin (IL)-6 [72] Trauma IL-10 [99], NT-proCNP [100], P-selectin [101] Catheter-related infections Citrulline [102] Infants with necrotic enterocolitis IP-10 [103]…”

Section: Situation Biomarkermentioning

confidence: 99%

Biomarkers of sepsis: time for a reappraisal

et al. 2020

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Introduction: Sepsis biomarkers can have important diagnostic, therapeutic, and prognostic functions. In a previous review, we identified 3370 references reporting on 178 different biomarkers related to sepsis. In the present review, we evaluate the progress in the research of sepsis biomarkers.Methods: Using the same methodology as in our previous review, we searched the PubMed database from 2009 until September 2019 using the terms "Biomarker" AND "Sepsis." There were no restrictions by age or language, and all studies, clinical and experimental, were included.Results: We retrieved a total of 5367 new references since our previous review. We identified 258 biomarkers, 80 of which were new compared to our previous list. The majority of biomarkers have been evaluated in fewer than 5 studies, with 81 (31%) being assessed in just a single study. Apart from studies of C-reactive protein (CRP) or procalcitonin (PCT), only 26 biomarkers have been assessed in clinical studies with more than 300 participants. Forty biomarkers have been compared to PCT and/or CRP for their diagnostic value; 9 were shown to have a better diagnostic value for sepsis than either or both of these biomarkers. Forty-four biomarkers have been evaluated for a role in answering a specific clinical question rather than for their general diagnostic or prognostic properties in sepsis. Conclusions:The number of biomarkers being identified is still increasing although at a slower rate than in the past. Most of the biomarkers have not been well-studied; in particular, the clinical role of these biomarkers needs to be better evaluated.

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Section: Situation Biomarkermentioning

confidence: 99%

Biomarkers of sepsis: time for a reappraisal

et al. 2020

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“…Additional le 1 (.pdf) Situation Biomarker To diagnose infection in patients with a particular pathology/condition After cardiac surgery Endocan [111], CD64 [112], pancreatic stone protein [113] After major surgery Peptidoglycan [114], elastase [115], leptin [103], calprotectin [94], a proliferation-inducing ligand [116], α-2 macroglobulin [108], lipopolysaccharide-binding protein [ To diagnose speci c types of infection Gram (-) vs Gram (+) Fibrin degradation products [128], lipopolysaccharidebinding protein [123], CD11b [106]…”

Section: Additional Filesmentioning

confidence: 99%

Biomarkers of sepsis: Time for a Reappraisal

Pierrakos

Velissaris

Bisdorff

et al. 2020

Preprint

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Introduction : Sepsis biomarkers can have important diagnostic, therapeutic, and prognostic functions. In a previous review, we identified 3370 references reporting on 178 different biomarkers related to sepsis. In the present review, we evaluate the progress in the research of sepsis biomarkers. Methods: Using the same methodology as in our previous review, we searched the PubMed database from 2009 until September 2019 using the terms “Biomarker” AND “Sepsis”. There were no restrictions by age or language and all studies, clinical and experimental, were included. Results: We retrieved a total of 5367 new references since our previous review. We identified 258 biomarkers, 80 of which were new compared to our previous list. The majority of biomarkers have been evaluated in fewer than 5 studies, with 81 (31%) being assessed in just a single study. Apart from studies of C-reactive protein (CRP) or procalcitonin (PCT), only 26 biomarkers have been assessed in clinical studies with more than 300 participants. Forty biomarkers have been compared to PCT and/or C-reactive protein CRP for their diagnostic value; 9 were shown to have a better diagnostic value for sepsis than either or both of these biomarkers. Forty-four biomarkers have been evaluated for a role in answering a specific clinical question rather than for their general diagnostic or prognostic properties in sepsis. Conclusions : The number of biomarkers being identified is still increasing although at a slower rate than in the past. Most of the biomarkers have not been well-studied; in particular the clinical role of these biomarkers needs to be better evaluated.

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“…Higher perioperative concentrations of endocan were observed in patients with the longest duration of norepinephrine support ( p = 0.007) [ 38 ]. Patients developing POP exhibited higher blood endocan levels before surgery and at 6 h post surgery than those who did not develop POP (Table 2 ) [ 42 , 43 ]. Thus, endocan allowed earlier identification of patients evolving to POP than PCT or CRP [ 35 , 36 ].…”

Section: Main Textmentioning

confidence: 99%

“…In routine practice, the average time to a formal diagnosis of pneumonia after cardiac surgery is 4.6 ± 3.7 days [ 43 ]. Blood endocan > 15 ng/ml 6 h after cardiac surgery had a sensitivity of 80% and a specificity of 100% to predict POP [ 42 ].…”

Section: Main Textmentioning

confidence: 99%

Endocan, sepsis, pneumonia, and acute respiratory distress syndrome

et al. 2018

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Acute respiratory distress syndrome (ARDS) and hospital-acquired pneumonia (HAP) are major problems of public health in intensive care units (ICUs), occurring in 15% of critically ill patients. Among the factors explaining ARDS development, sepsis is known as a frequent cause. Sepsis, ARDS, and HAP increase morbidity, mortality, length of stay in the ICU, and the overall costs of healthcare. The major challenge remains to identify accurately among critically ill patients those at risk of poor outcomes who could benefit from novel therapies. Endocan is released by the pulmonary endothelium in response to local or systemic injury. It inhibits mainly leukocyte diapedesis rather than leukocyte rolling or adhesion to the endothelial cells both in vitro and in vivo. Endocan was evaluated in 25 clinical reports, including 2454 critically ill patients and 452 healthy controls. The diagnostic value of endocan for sepsis or sepsis severity was equal to procalcitonin but its prognostic value was better. A predictive value for postoperative pneumonia was evidenced in two studies, and a predictive value for ARDS in four studies from three independent centers. This review presents an overview of the structure, expression, and functions of endocan. We also hereby summarize the potential applications of endocan in the prediction and prognosis of ARDS and HAP, as well as in the prognosis of sepsis.

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Relevance of Endothelial Cell-Specific Molecule 1 (Endocan) Plasma Levels for Predicting Pulmonary Infection after Cardiac Surgery in Chronic Kidney Disease Patients: The Endolung Pilot Study

Cited by 9 publications

References 27 publications

Biomarkers of sepsis: time for a reappraisal

Biomarkers of sepsis: time for a reappraisal

Biomarkers of sepsis: Time for a Reappraisal

Endocan, sepsis, pneumonia, and acute respiratory distress syndrome

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