Relevance of glutathione S-transferase M1 and cytochrome P450 1A1 genetic polymorphisms to the development of head and neck cancers

Reszka, Edyta; Czekaj, Piotr; Adamska, Jolanta; Wąsowicz, Wojciech

doi:10.1515/cclm.2008.227

Cited by 21 publications

(12 citation statements)

References 23 publications

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“…When the genotypes were included in analyses, we initially found similar frequencies of the CYP1A1 A4889G and T6235C and GSTM1 and GSTT1 genotypes in patients and controls, suggesting that the polymorphisms did not alter the risk for HNSCC, according to previous evaluations [8,9,[18][19][20][21][22][23]. In contrast, increased risks for disease in carriers of the variant alleles of the CYP1A1 A4889G [22,24] and T6235CC [22,[25][26][27][28] and the GSTM1 [8,23,25,26,[28][29][30][31][32] and GSTT1 null [26,33] genotypes were also previously reported.…”

Section: Discussionmentioning

confidence: 87%

CYP1A1, GSTM1 and GSTT1 polymorphisms, tobacco and alcohol status and risk of head and neck squamous cell carcinoma

et al. 2011

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We examined the influence of the CYP1A1 A4889G and T6235C, GSTM1 and GSTT1 polymorphisms, involved in carcinogen metabolism, on the head and neck (HN) squamous cell carcinoma (SCC) risk. DNA from 142 HNSCC patients and 142 controls was analysed by polymerase chain reaction (PCR)-restriction fragment length polymorphism or multiplex-PCR for the polymorphisms analyses. Excesses of the CYP1A1 4889AG+GG and 4889AG+GG plus GSTT1 null genotype were seen in patients with heavy tobacco habit compared with controls (41.9% versus 26.8%, P = 0.03; 26.2% versus 10.3%, P = 0.04, respectively). Carriers of the referred genotypes and heavy tobacco consumption were under a 2.0-fold and 2.8-fold increased risks for HNSCC than others, respectively. The CYP1A1 6235TC+CC plus GSTM1 and GSTT1 null genotypes were more common in pharyngeal SCC patients than in controls (5.3% versus 0.7%, P = 0.04). Carriers of the combined genotype had 16.0-fold increased risk for the disease than others. The frequency of one null genotype of the GSTM1 or GSTT1 gene was higher in patients with pharyngeal SCC and heavy smoking status than in controls (76.3% versus 57.7%, P = 0.04). Carriers of the referred genotype and heavy tobacco status had a 2.4-fold increased risk for pharyngeal SCC than others. In contrast, the CYP1A1 6235TC+CC genotype was more common in controls than in laryngeal SCC patients (35.9% versus 21.6%, P = 0.01). Carriers of the genotype had a 0.2-fold decreased risk for the disease than others. Our data present preliminary evidence that inherited combined CYP1A1 A4889G and T6235C abnormalities and GSTM1 and GSTT1 pathways are important determinants of HNSCC, particularly pharyngeal SCC in heavy smoking individuals from south-eastern Brazil.

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Section: Discussionmentioning

confidence: 87%

CYP1A1, GSTM1 and GSTT1 polymorphisms, tobacco and alcohol status and risk of head and neck squamous cell carcinoma

et al. 2011

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“…In a study of Polish patients, CYP1A1 * 4 allele and CYP1A1 * 4/ * 4 genotype were associated with HNC risk [128]. However, Reszka et al [129] found no significant association of CYP1A1 462Val alleles with increased HNC risk in Polish patients. Moreover, in a recent meta-analysis study, no association between CYP1A1 Ile462Val polymorphism and HNC risk was found [130].…”

Section: Head and Neck Cancermentioning

confidence: 95%

Cytochrome P450 in Cancer Susceptibility and Treatment

Mittal

Tulsyan

Kumar

et al. 2015

Advances in Clinical Chemistry

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“…No statistical differences were found for the GSTP1 AA(Ile/Ile) and GSTP1 AB(Ile/Val) or GSTP1BB (Val/Val) genotypes, which confirmed that GSTP1 polymorphism is not associated with altered susceptibility to HNSCC [77]. Similarly, Reszka et al [78] found no statistically significant risk of HNSCC in patients carrying GSTP1 105Val alleles in a Polish study population (OR=0.97; CI=0.59-1.58) [78].…”

Section: Gstp1mentioning

confidence: 71%

Head and Neck Squamous Cell Carcinoma: Prognosis using molecular approach

Mazumder

Nath

et al. 2014

Open Life Sciences

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Head and neck squamous cell carcinoma (HNSCC) is the fifth most prevalent cancer worldwide. Apart from various known clinicopathogical factors, it is still a major concern as many genetic and epigenetic alterations bring about the possibility of this deadly disease. The aim of this review is to explore the possible role of DNA repair pathways and the polymorphic status of DNA repair genes (XPA, XPC, XPD, XRCC1 and XRCC3) in the onset of HNSCC, along with sequence variations in genes such as Glutathione S-transferases (GSTT1, M1 and P1) that are significantly associated with HNSCC risk. We also focus on the p53 gene mutation induced by various etiological agents and threat factors with its implications towards HNSCC, and emphasise the current therapeutic interventions in treating HNSCC.

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Relevance of glutathione S-transferase M1 and cytochrome P450 1A1 genetic polymorphisms to the development of head and neck cancers

Abstract: Our findings corroborate metabolic genes interactions, especially for CYP1A1 462Val alleles and GSTM1 homozygous deletion, in the development of head and neck cancer in the investigated population groups in Poland.

Cited by 21 publications

References 23 publications

CYP1A1, GSTM1 and GSTT1 polymorphisms, tobacco and alcohol status and risk of head and neck squamous cell carcinoma

CYP1A1, GSTM1 and GSTT1 polymorphisms, tobacco and alcohol status and risk of head and neck squamous cell carcinoma

Cytochrome P450 in Cancer Susceptibility and Treatment

Head and Neck Squamous Cell Carcinoma: Prognosis using molecular approach

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