Relevance of Helicobacter pylori infection in Egyptian multiple sclerosis patients

Gerges, Steven Emil; Alosh, T K; Khalil, Salma; Din, Mona Mokhtar Waheed El

doi:10.1186/s41983-018-0043-x

Cited by 17 publications

(21 citation statements)

References 19 publications

(23 reference statements)

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“…Helicobacter pylori (H. pylori) is a Gram-negative spiral-shaped bacterium [1] with worldwide distribution. About 58% (varying from 39.9-91.7%) of the global population is estimated to be colonized with H. pylori and its prevalence is even higher in less-industrialized countries [2][3][4]. H. pylori can cause chronic gastritis, peptic ulcers, gastric adenocarcinoma, as well as mucosa-associated lymphoid tissue lymphoma [5][6][7][8][9][10].…”

Section: Introductionmentioning

confidence: 99%

Association between Active Helicobacter pylori Infection and Glaucoma: A Systematic Review and Meta-Analysis

et al. 2020

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Background: Glaucoma is the second most common cause of blindness worldwide affecting almost 70 million individuals. Helicobacter pylori (H. pylori) is a widespread pathogen with systematic pathogenicity. This meta-analysis aimed to estimate the contradictory data regarding a potential association between active H. pylori infection and glaucoma. Materials and Methods: A research in MEDLINE/PubMed and Google Scholar was conducted and original studies investigating the relationship between H. pylori infection and glaucoma were included. Analysis was performed with random effects model. The main outcome was the odds ratio (OR) with 95% confidence intervals (CI) of H. pylori infection as a risk factor for glaucoma. A parallel analysis studied the role of active infection as indicated by histology and the titer of anti-H. pylori antibodies. For the anti-H. pylori antibody titers, weighted mean differences (WMD) were estimated between patients and controls. Results: Fifteen studies were included, with 2664 participants (872 patients with glaucoma and 1792 controls), divided into primary open-angle glaucoma (POAG), normal tension glaucoma (NTG) and pseudo-exfoliation glaucoma (PEG). The association between H. pylori infection and overall glaucoma was significant (OR = 2.08, CI 95% 1.48–2.93) with moderate heterogeneity (I2 = 61.54%). After stratification by glaucoma subtype, heterogeneity was eliminated in the NTG subgroup. Studies with healthy controls, and controls with anemia yielded very low or no heterogeneity, respectively. Gastric biopsy to document active H. pylori infection yielded the highest OR (5.4, CI: 3.17–9.2, p < 0.001) and null heterogeneity. For anti-H. pylori antibody titers, there was a significant difference in WMD between patients and controls (WMD 15.98 IU/mL; 95% CI: 4.09–27.87; p = 0.008); values were greater in glaucoma patients, with high heterogeneity (I2: 93.8%). Meta-regression analysis showed that mean age had a significant impact on glaucoma (p = 0.037). Conclusions: Active H. pylori infection may be associated with glaucoma with null heterogeneity, as, beyond histology, quantified by anti-H. pylori titers and increases with age.

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Section: Introductionmentioning

confidence: 99%

Association between Active Helicobacter pylori Infection and Glaucoma: A Systematic Review and Meta-Analysis

et al. 2020

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“…In the line with our study, previous investigations showed an association between SPMS and HP IgG seropositivity. 19 , 20 On univariate model, EDSS score and SPMS had association with HP IgG seropositivity, but in multivariate model, only SPMS had association. It is possible, therefore, that the association of HP infection with EDSS score is related to high EDSS score in SP course.…”

Section: Discussionmentioning

confidence: 92%

“…Whilst some research has been carried out on the patients with MS, limited studies have attempted to investigate the association of HP infection with different clinical courses of MS. Interestingly, it has been suggested that HP infection may have association with secondary progressive MS (SPMS). 19 , 20 Also, a longitudinal study found high proportion of patients with CIS with HP infection and proposed that eradication of HP infection might reduce the risk of conversion from CIS to definite MS. 21 …”

Section: Introductionmentioning

confidence: 99%

Association of helicobacter pylori with multiple sclerosis: Protective or risk factor?

Mirmosayyeb

Barzegar

Nehzat

et al. 2020

CJN

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Background: Multiple sclerosis (MS) is a common autoimmune inflammatory disease in the central nervous system (CNS) without exact pathology. Environmental factors such as infections have a causal or protective role in MS. Helicobacter pylori (HP) is one of the infections in digestive diseases and previous studies reported controversial findings of this infection role in MS. So, we conducted this study to assess the frequency of HP infection in patients with MS in comparison to the healthy population. Methods: This cross-sectional study was undertaken between 2015 and 2019. 191 participants including 58 patients with clinically isolated syndrome (CIS), 57 patients with relapsing-remitting MS (RRMS), 39 patients with secondary progressive MS (SPMS), and 39 age- and sex-matched healthy controls (HCs) were tested for the presence of HP immunoglobulin G (IgG) and IgM antibodies (Abs) in their serum sample. Results: The frequency of HP IgG seropositivity in patients with SPMS was significantly higher than patients with CIS [Odds ratio (OR): 6.333, 95% confidence interval (CI): 2.522-15.906, P < 0.001], patients with RRMS (OR: 4.583, 95% CI: 1.842-11.407, P = 0.001), and HCs (OR: 8.485, 95% CI: 3.058-23.540, P < 0.001). We did not find a significant difference among other study groups regarding IgG seropositivity. No significant difference among groups regarding HP IgM seropositivity was evident. On univariate model, Expanded Disability Status Scale (EDSS) score (OR: 1.038, 95% CI: 1.038-1.460, P = 0.017) and SPMS (OR: 4.583, 95% CI: 1.842-11.407, P = 0.001) were predictor for HP IgG seropositivity. On multivariate model, only SPMS had higher risk for HP IgG seropositivity compared to RRMS (OR: 5.554, 95% CI: 1.327-23.253, P = 0.019). We did not find a significant association between clinical and demographic variables with HP IgM seropositivity. Conclusion: Based on our findings, progressive MS and HP infection may have association. Further longitudinal studies with large sample size are needed to determine the role of HP infection in MS.

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“…Its prevalence is about 58% (varying from 39.9% to 91.7%). 7,73 Likewise, there has been noticed a remarkable increase in the incidence of EoE in the last two decades, constituting EoE nowadays as a major etiology of UGI morbidity. 35,37 According to the recent data, a global average EoE incidence is 3.7/100,000 per year, with variations ranging from 2.1/100,000 per year in the Netherlands to 12.8/100,000 per year in the United States (Ohio).…”

Section: H Pylori and Eoe: Illuminating The Gapmentioning

confidence: 99%

Reconsidering the “protective” hypothesis of Helicobacter pylori infection in eosinophilic esophagitis

Doulberis

Kountouras

Rogler

2020

Annals of the New York Academy of Sciences

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Since its discovery, Helicobacter pylori (H. pylori) has attracted attention in the biomedical world with its numerous pathophysiologic implications, both gastrointestinal and systemic. Beyond its well‐established carcinogenic properties, emerging evidence also supports “harmful” proinflammatory and neurodegenerative roles of H. pylori. On the other hand, H. pylori infection has been proposed to be “protective” against several diseases, such as asthma and gastroesophageal reflux disease. Eosinophilic esophagitis (EoE) is a relatively new, allergen/immune–mediated disease, which has also been linked to these considerations. Main arguments are a postulated shift of immune responses by H. pylori from T helper 2 (TH2) to TH1 polarization, as well as a potential decline of the H. pylori burden with the dramatic parallel rise of ΕοΕ: a series of observational studies reported an inverse association. In this review, we counter these arguments by providing further epidemiological data, which point out that this generalization might be rather incomplete. We also discuss the limitations of the existing studies evaluating a possible association. Furthermore, we provide current evidence on common pathogenetic components, which share both entities. In summary, the claim that H. pylori is protective against EoE is rather incomplete, and further mechanistic studies are necessary to elucidate a possible association.

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Relevance of Helicobacter pylori infection in Egyptian multiple sclerosis patients

Cited by 17 publications

References 19 publications

Association between Active Helicobacter pylori Infection and Glaucoma: A Systematic Review and Meta-Analysis

Association between Active Helicobacter pylori Infection and Glaucoma: A Systematic Review and Meta-Analysis

Association of helicobacter pylori with multiple sclerosis: Protective or risk factor?

Reconsidering the “protective” hypothesis of Helicobacter pylori infection in eosinophilic esophagitis

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