Relevance of <i>KISS1</i> gene polymorphisms in susceptibility to polycystic ovary syndrome and its associated endocrine and metabolic disturbances

Daghestani, MH; Daghistani, Mamoon; Ambreen, Khushboo; Almuammar, MN; Neghery, LM Al; Warsy, Arjumand S.

doi:10.1080/09674845.2020.1726662

Cited by 8 publications

(11 citation statements)

References 32 publications

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“…Five papers did not report separated information for control groups, 4 included duplicate information, and one did not report the primary outcome (Figure 1). Finally, a total of 18 studies were evaluated for qualitative and quantitative assessment [29][30][31][32][33][34][35][36][37][38][39][40][41][42][43][44][45][46][47].…”

Section: Selection Of Studiesmentioning

confidence: 99%

“…Dr. Xiaoli Chen informed us that a publication in the Chinese language [48] was a preliminary article of the final publication in English [34]. We also contacted the correspondent author of 4 papers published over years [35,[49][50][51] without getting any response.…”

Section: Selection Of Studiesmentioning

confidence: 99%

“…Therefore, we excluded earlier publications to ensure the use of only the largest and most recent participants and to prevent data set inflation [35].…”

Section: Selection Of Studiesmentioning

confidence: 99%

“…The 18 selected studies included 1,282 participants who suffer PCOS and 997 controls, published between 2006 [44] and 2020 [35,39,42] (Table 1). PCOS sample sizes across studies ranged from 20 [33] to 250 [37].…”

Section: Characteristics Of Included Studiesmentioning

confidence: 99%

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Circulating kisspeptin and anti-müllerian hormone levels, and insulin resistance in women with polycystic ovary syndrome: A systematic review, meta-analysis, and meta-regression

Pérez‐López

Ornat

López‐Baena

et al. 2021

European Journal of Obstetrics & Gynecology and Reproductiv

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Objective: This systematic review and meta-analysis aimed to summarize the available evidence regarding circulating kisspeptin and anti-müllerian hormone (AMH) and the homeostasis model assessment of insulin resistance (HOMA-IR) index in adolescents and women with and without polycystic ovary syndrome (PCOS).Method: We performed a comprehensive literature search in Medline, Embase, Cochrane, Scopus, and Web of Science for studies evaluating circulating kisspeptin levels in women with and without PCOS published until September 24th, 2020. Coprimary outcomes were the HOMA-IR index and AMH. The quality of included studies was assessed using the Newcastle-Ottawa Scale. Random-effects models were used to estimate outcomes, and effects reported as mean difference (MD) or standardized MD (SMD) and their 95% confidence interval (CI). The systematic review and meta-analysis was registered in the International Prospective Register of Systematic Reviews (PROSPERO) as number CRD42020205030. Results: We evaluated 18 studies including, 1,282 PCOS cases and 977 controls. Participants with PCOS were younger (MD=-2.38 years, 95%CI -4.32 to -0.44), with higher BMI (MD=1.16, 95% CI 0.54 to 1.78), waist-to-hip ratio (MD=0.04, 95%CI 0.02 to 0.05), circulating kisspeptin (SMD=1.15, 95%CI 0.68 to 1.62), luteinizing hormone (SMD=1.29, 95%CI 0.76 to 1.83), AMH (SMD=0.97, 95%CI 0.60 to 1,34), total testosterone (SMD=2.48, 95%CI 1.73 to 3.23), free testosterone (SMD=1.37, 95%CI 0.56 to 2.17), and dehydroepiandrosterone sulfate (SMD=0.72, 95%CI 0.32 to 1.13) levels, and Ferriman-Galweg score (SMD = 5.08, 95%CI 2.76 to 7.39), and lower sex hormone-binding globulin level (SMD=-1.34, 95%CI -2.15 to -0.52). Besides, participants with PCOS had higher HOMA-IR index (SMD=0.76, 95%CI 0.35 to 1.17), and circulating insulin (SMD=0.75, 95%CI 0.30 to 1.19), leptin (SMD=2.82, 95%CI 1.35 to 4.29), and triglycerides (SMD=2.15, 95%CI 1.08 to 3.23) levels than participants without the syndrome. The meta-regression did not identify significant factors influencing circulating kisspeptin. Conclusion:Patients with PCOS showed higher kisspeptin, LH, insulin, AMH, and androgen levels and HOMA-IR index, and lower sex hormone-binding globulin levels than those without the syndrome.

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Section: Selection Of Studiesmentioning

confidence: 99%

Section: Selection Of Studiesmentioning

confidence: 99%

“…Therefore, we excluded earlier publications to ensure the use of only the largest and most recent participants and to prevent data set inflation [35].…”

Section: Selection Of Studiesmentioning

confidence: 99%

Section: Characteristics Of Included Studiesmentioning

confidence: 99%

See 2 more Smart Citations

Circulating kisspeptin and anti-müllerian hormone levels, and insulin resistance in women with polycystic ovary syndrome: A systematic review, meta-analysis, and meta-regression

Pérez‐López

Ornat

López‐Baena

et al. 2021

European Journal of Obstetrics & Gynecology and Reproductiv

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“…In the third paper in this issue related to infertility, Daghestani et al [15] study the relevance of KISS1 gene polymorphisms in susceptibility to polycystic ovary syndrome and associated endocrine and metabolic disturbances. Polycystic ovary syndrome (PCOS) is a gynaecological condition that occurs in 3-10% of women of childbearing age.…”

Section: Molecular Genetic Studiesmentioning

confidence: 99%

British Journal of Biomedical Science in 2020. What have we learned?

Brown

Orchard

Rhodes

2020

British Journal of Biomedical Science

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Each year the British Journal of Biomedical Science publishes a 'What have we learned' editorial designed to introduce readers within the major disciplines of laboratory medicine to developments outside their immediate area. In addition it is designed to inform a wider readership of the advances in the diagnosis and treatment of disease. To this end, in 2020 the journal published 39 articles covering the disciplines within Biomedical Science in the 4 issues comprising volume 77. These included a review of COVID-19 in this issue, 27 original articles, 6 Biomedical Science 'In Brief' and 4 case histories. 27 of the articles involved molecular techniques, with one of these comparing results with a mass spectrometry based method. The preponderance of molecular genetic studies gives us a good idea of the likely future direction of the disciplines

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Role of the Q36R polymorphism in the KISS1 gene in female infertility

Al-Mutawa

2023

Journal of King Saud University - Science

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Relevance of KISS1 gene polymorphisms in susceptibility to polycystic ovary syndrome and its associated endocrine and metabolic disturbances

Cited by 8 publications

References 32 publications

Circulating kisspeptin and anti-müllerian hormone levels, and insulin resistance in women with polycystic ovary syndrome: A systematic review, meta-analysis, and meta-regression

Circulating kisspeptin and anti-müllerian hormone levels, and insulin resistance in women with polycystic ovary syndrome: A systematic review, meta-analysis, and meta-regression

British Journal of Biomedical Science in 2020. What have we learned?

Role of the Q36R polymorphism in the KISS1 gene in female infertility

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