Relevance of lymph node metastasis along the superior mesenteric vein in gastric cancer

An, Ji Yeong; Pak, Kyung Ho; Inaba, Kazuki; Cheong, Jae‐Ho; Hyung, Woo Jin; Noh, Sung Hoon

doi:10.1002/bjs.7414

Cited by 24 publications

(26 citation statements)

References 12 publications

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“…PAND, however, is no longer performed as a standard procedure, because the prospective randomized Japan Clinical Oncology Group (JCOG) study 9501 failed to demonstrate the survival benefit of D2 plus PAND over D2 alone 37,38. Also, lymph node station 14v (along the superior mesenteric vein) has been excluded from D2, even for distal tumors, in the new treatment guidelines set forth by the Japanese Gastric Cancer Association (JGCA),39 which is consistent with the findings of retrospective study from our own institution in which 14v-positive gastric cancer demonstrated poor prognosis, similar to that of metastatic disease 40,41…”

Section: Present Status Of Gastric Cancer Managementsupporting

confidence: 71%

Current Management and Future Strategies of Gastric Cancer

et al. 2012

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The overall prognosis of gastric cancer has gradually improved over the past decades with growing awareness of potential carcinogens, surveillance programs and early diagnosis, as well as advances in surgical techniques and multimodality treatments. Nevertheless, the outcome of advanced stage disease still remains poor with currently available treatments, and a worldwide consensus on the standard management thereof has not been established. To improve prognosis and quality of life in gastric cancer patients, both standardization and individualization of managements are imperative. Diagnostic tests and surgical procedures need to be further sophisticated and standardized based on more recent evidences from ongoing and future randomized controlled trials, while comprehensive management should be individualized to each patient. Future challenges lie with how to optimize personalized therapies by deciphering biological complexity of gastric cancer and incorporating molecular biomarkers in clinical practice to forecast prognosis and to guide targeted therapeutics in adjunct to current standards of care.

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Section: Present Status Of Gastric Cancer Managementsupporting

confidence: 71%

Current Management and Future Strategies of Gastric Cancer

et al. 2012

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“…Further analysis of these tumor cells revealed that the HOST2 expression level in GC cells with distant metastasis was higher than those without. In addition, highly expressed HOST2 was detected in the patients of lymph node metastasis which is the first transmission in many metastatic tumors; cancer cells are then transported to other organs by blood flow [22].…”

Section: Discussionmentioning

confidence: 99%

Long non-coding RNA HOST2 enhances proliferation and metastasis in gastric cancer

Liu¹,

Zhang²,

Chu³

et al. 2019

neo

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This study investigates the influence of long noncoding RNA HOST2 on the biological functions of gastric cancer cells; including proliferation, migration and invasion. Differentially expressed lncRNAs in gastric cancer (GC) were screened by microarray analysis, and HOST2 expression in GC tissues and cell lines was determined by quantitative real-time PCR (qRT-PCR). GC cell proliferation, migration and invasion were detected by CCK-8, wound healing and transwell assays. Western blot investigated expression of epithelial-mesenchymal transition (EMT) related proteins, and association was established between over-expressed HOST2 and the number of patients with lymph node and distant metastasis. HOST2 expression was also positively related to GC cell invasion ability, and although its expression in the p-shHOST2 group was remarkably decreased, it was significantly higher than in the Mock and NC groups. Compared to the Mock and NC groups, the p-shHOST2 group presented significant decreases in proliferation and wound healing rates, and the reverse result was noted in the p-HOST2 group. In addition, the number of p-shHOST2 group invasive cells was remarkably less than in the Mock and NC group, and the opposite result was achieved in the p-HOST2 group. Moreover, p-HOST2 had more significant EMT, but this was suppressed in the p-shHOST2 group. Finally, HOST2 silencing suppressed GC cell proliferation, migration and invasion; and it could therefore be considered as a novel biomarker and therapeutic target in gastric cancer.

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“…In contrast, some researchers have reported that the No. 14v lymph node metastasis is a poor prognostic factor, and can be regarded as distant metastasis [7]. Meanwhile, the rate of No.…”

Section: Discussionmentioning

confidence: 99%

Five-year Survival Associated with Stage I Gastric Cancer after Resection of Early Recurrence at Nodal Station No. 14v: a Case Report

et al. 2017

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The role of nodal station No. 14v (along the superior mesenteric vein) in lymphadenectomy for distal gastric cancer remains elusive. A 73-year-old woman underwent endoscopic submucosal dissection for gastric cancer, and was referred to our division for additional surgery because of pathologically non-curative resection. A laparoscopic distal gastrectomy with D1+ dissection was performed, with a final diagnosis of pT1bN1M0, Stage IB (2 nodal metastases to No. 6). Four months post-surgery, abdominal computed tomography revealed a 14-mm solitary nodule along the superior mesenteric vein. The lesion was excised and pathologically identified as a lymph node metastasis. Adjuvant chemotherapy with tegafur-gimeracil-oteracil potassium (S-1) was administered for the metastasis. Presently the patient survives without recurrence, 5.5 years after the second operation. Our findings suggest that there is lymphatic flow from the No. 6 to the No. 14v nodal station. Some patients with a No. 6 metastasis may benefit from a No. 14v lymphadenectomy, even in early-staged disease.

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Relevance of lymph node metastasis along the superior mesenteric vein in gastric cancer

Abstract: 14v status is an independent prognostic factor for gastric cancer, with 14v-positive gastric cancer having a poor prognosis, similar to that of M1 disease. The exclusion of 14v in regional lymph node dissection should be considered.

Cited by 24 publications

References 12 publications

Current Management and Future Strategies of Gastric Cancer

Current Management and Future Strategies of Gastric Cancer

Long non-coding RNA HOST2 enhances proliferation and metastasis in gastric cancer

Five-year Survival Associated with Stage I Gastric Cancer after Resection of Early Recurrence at Nodal Station No. 14v: a Case Report

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