Relevance of nitric oxide in pain mechanisms and pain management

Janicki, Piotr K.; Jeske-Janicka, Magdalena

doi:10.1007/s11916-998-0022-5

Cited by 13 publications

(6 citation statements)

References 34 publications

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“…[9] Evidence has shown the involvement of both central and peripheral NO in nociceptive processing. [10] It is now well accepted that NO plays a vital role in neural transmission and acts as second messenger at both central and peripheral level. [11] However, when NO react with superoxide radical it forms peroxynitrite which is several times more potent than their parents (superoxide and NO) in terms of tissue toxicity.…”

Section: Introductionmentioning

confidence: 99%

Effect of Ashwagandha (Withania somnifera) against chronic constriction injury induced behavioral and biochemical alterations: Possible involvement of nitric oxide mechanism

Kumar

Meena

Pottabathini

2014

Int J Nutr Pharmacol Neurol Dis

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Aim: Neuropathic pain (NP) arises due to lesion or disease in somatosensory nervous system. Recent reports indicate the role of Withania somnifera (WS) in various inflammatory pain conditions. The objective of the present study was to explore the possible protective effect of WS against chronic constriction injury (CCI) induced NP in rats. Materials and Methods: CCI of sciatic nerve was performed in male Wistar rats. Various behavioral parameters (thermal hyperalgesia, cold allodynia) followed by biochemical parameters (lipid peroxidation, reduced glutathione, catalase and nitrite) were assessed in sciatic nerves. Drugs were administered consecutively for 21 days from the day of surgery. CCI to sciatic nerve significantly caused thermal hyperalgesia, cold allodynia and oxidative damage in the sciatic nerves when compared with naive and sham control. Results: Chronic administration of WS (100 and 200 mg/kg, p.o.) significantly attenuated hyperalgesia, cold allodynia and oxidative damage (as indicated by reduction in lipid peroxidation, nitrite concentration, restoration of reduced glutathione and catalase activity). Further, L-NAME (5 mg/kg, i.p.) pre-treatment with WS (100 mg/kg, p.o.) significantly potentiated the protective effect of WS which was significant when compared with their effect per se However, L-arginine (100 mg/kg, i.p.) pre-treatment with WS (100 mg/kg, p.o.) significantly reversed the protective effects of WS in sciatic nerve. Conclusion: Result of present study suggests that nitric oxide mechanism could be involved in the protective effect of WS against CCI induced behavior alterations and oxidative damage in rats.

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Section: Introductionmentioning

confidence: 99%

Effect of Ashwagandha (Withania somnifera) against chronic constriction injury induced behavioral and biochemical alterations: Possible involvement of nitric oxide mechanism

Kumar

Meena

Pottabathini

2014

Int J Nutr Pharmacol Neurol Dis

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“…The role of NO in the peripheral nociceptive process is more complex and is reported to include both nociceptive and non-nociceptive. These results depend on studies in experimental animal models with the application of nociceptive stimuli [45]. The hypothesis regarding the mechanism of action of paracetamol which shows a central potential mechanism is inhibition through the inhibition of Larginine NO nociceptive pathway.…”

Section: Chronic Low Back Pain (Clbp)mentioning

confidence: 99%

The Role of Substance P in Chronic Low Back Pain (CLBP)

Rachmawati

2020

J. Islamic Pharm.

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<p>Low Back Pain is one of the disease that causing global disability in the worldwide. In the past 10 years, prevalence of LBP has not decreased, it makes global burden increase substantially. Chronic low back pain(CLBP) is pain that is almost experienced daily by patients in the lower back region in a period of more than 3 months. Chronic low back pain is a mixture of pain that arises through nociceptive and neuropathic mechanisms. Over the past decade, numerous guidelines have been used in the management of CLBP. Problems that are still a controversy include the management of pain. The mechanism of many treatment measures is still in the low to moderate effectiveness stage, so that the pain management target is not optimal. Substance P is a neuropeptide that release both in acute and chronic pain. Therefore study about mechanisms that affect SP release may show important information regarding pathological alterations in pain perception.</p>

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“…Nitric oxide synthase (NOS) produces NO by oxidation of L-arginine to L-citrulline. The essential reductive cofactor NADPH or the NOS enzyme involved in NO synthesis can be used as a marker of NO presence 17 . Many researchers have reported that inhibition or knockout of NOS results in pain persistence 18 .…”

Section: Introductionmentioning

confidence: 99%

Evaluation of c-Fos protein expression and NADPH-d reactivity in Neurobion pretreated rat model of inflammatory pain

Zarei

Shahriari-Khalaji

Andolina

et al. 2023

Preprint

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B-vitamins have been evaluated as a useful adjuvant therapy to treat pain. In spite of clinical and experimental evidence indicating the analgesic effect of B-vitamins, few studies have investigated their effect on aspects of the inflammatory pain response. In the present study, we investigated the analgesic effect of chronic application of B-complex vitamins (Neurobion) using an inflammatory experimental pain model in rats. Nociceptive behavioral responses were evaluated in male Wistar rats after plantar injection of formalin, comparing groups with (TG) and without (CG) Neurobion pretreatment. In addition, neuronal activity in the central pain pathway was evaluated using c-Fos immunohistochemical reactivity and NADPH-d histochemistry. A highly significant reduction of painful behaviors such as licking and flinching were observed in TG, especially during the secondary phase of the formalin test compared to CG. Results suggest that long-term pre-treatment using Neurobion can have a beneficial effect in reducing the chronic phase of pain. In addition, we observed a downregulation of c-Fos and NADPH-d in dorsal spinal neurons, suggesting that the antinociceptive effect induced by Neurobion could be due to a suppression of nociceptive transmission at the spinal level, particularly in the afferent regions of the dorsal spinal horn, which these neurons utilizing nitric oxide at least as one of their pain neurotransmitters.

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Relevance of nitric oxide in pain mechanisms and pain management

Cited by 13 publications

References 34 publications

Effect of Ashwagandha (Withania somnifera) against chronic constriction injury induced behavioral and biochemical alterations: Possible involvement of nitric oxide mechanism

Effect of Ashwagandha (Withania somnifera) against chronic constriction injury induced behavioral and biochemical alterations: Possible involvement of nitric oxide mechanism

The Role of Substance P in Chronic Low Back Pain (CLBP)

Evaluation of c-Fos protein expression and NADPH-d reactivity in Neurobion pretreated rat model of inflammatory pain

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