Relevance of organ(s)-on-a-chip systems to the investigation of food-gut microbiota-host interactions

García-Gutiérrez, Enriqueta; Cotter, Paul D.

doi:10.1080/1040841x.2021.1979933

Cited by 27 publications

(20 citation statements)

References 238 publications

(254 reference statements)

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“…Besides the aforementioned applications, GoC has been shown to conduct researches that relate to many other interactions between the gut and the microbiome, such as pathogen infection and gut inflammation, food digestion and metabolism, etc. ( Steinway et al, 2020 ; Garcia-Gutierrez and Cotter, 2021 ). In addition to GoC, many other OoC systems have been constructed for different research purposes, but they were barely used to study host-microbiome interactions.…”

Section: Applicationsmentioning

confidence: 99%

Emerging microfluidic technologies for microbiome research

Wen

et al. 2022

Front. Microbiol.

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The importance of the microbiome is increasingly prominent. For example, the human microbiome has been proven to be strongly associated with health conditions, while the environmental microbiome is recognized to have a profound influence on agriculture and even the global climate. Furthermore, the microbiome can serve as a fascinating reservoir of genes that encode tremendously valuable compounds for industrial and medical applications. In the past decades, various technologies have been developed to better understand and exploit the microbiome. In particular, microfluidics has demonstrated its strength and prominence in the microbiome research. By taking advantage of microfluidic technologies, inherited shortcomings of traditional methods such as low throughput, labor-consuming, and high-cost are being compensated or bypassed. In this review, we will summarize a broad spectrum of microfluidic technologies that have addressed various needs in the field of microbiome research, as well as the achievements that were enabled by the microfluidics (or technological advances). Finally, how microfluidics overcomes the limitations of conventional methods by technology integration will also be discussed.

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Section: Applicationsmentioning

confidence: 99%

Emerging microfluidic technologies for microbiome research

Wen

et al. 2022

Front. Microbiol.

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“…Accurate modelling of quorum sensing in foods and the human gut is necessary in order to establish prevalence, relevance and to evaluate potential interventions. Ex vivo modelling of the human gut, such as through colonic models and gut-on-a-chip approaches, can provide an opportunity to benchmark quorum sensing activity at various points in the digestive process (Garcia-Gutierrez and Cotter, 2021). Fermented foods have also been demonstrated to be tractable and convenient experimental models for studying community assemblage in food microbiomes (Wolfe and Dutton, 2015) and could be evaluated as models for QS studies.…”

Section: Methods For the Analysis Of Qsmmentioning

confidence: 99%

Quorum sensing in human gut and food microbiomes: Significance and potential for therapeutic targeting

Falà

Álvarez‐Ordóñez²,

Filloux³

et al. 2022

Front. Microbiol.

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Human gut and food microbiomes interact during digestion. The outcome of these interactions influences the taxonomical composition and functional capacity of the resident human gut microbiome, with potential consequential impacts on health and disease. Microbe-microbe interactions between the resident and introduced microbiomes, which likely influence host colonisation, are orchestrated by environmental conditions, elements of the food matrix, host-associated factors as well as social cues from other microorganisms. Quorum sensing is one example of a social cue that allows bacterial communities to regulate genetic expression based on their respective population density and has emerged as an attractive target for therapeutic intervention. By interfering with bacterial quorum sensing, for instance, enzymatic degradation of signalling molecules (quorum quenching) or the application of quorum sensing inhibitory compounds, it may be possible to modulate the microbial composition of communities of interest without incurring negative effects associated with traditional antimicrobial approaches. In this review, we summarise and critically discuss the literature relating to quorum sensing from the perspective of the interactions between the food and human gut microbiome, providing a general overview of the current understanding of the prevalence and influence of quorum sensing in this context, and assessing the potential for therapeutic targeting of quorum sensing mechanisms.

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“…Due to complex gut dynamics, host–microbiome interactions, and species differences, the gut-on-a-chip (GOC) system is a particularly necessary model for advancing knowledge of the gut physiology and disease etiology [ 36 , 37 , 38 , 39 ]. The history of the development of the gut chip is indicated in Figure 2 .…”

Section: Introductionmentioning

confidence: 99%

The Gut–Organ-Axis Concept: Advances the Application of Gut-on-Chip Technology

Guo

Chen

Gong

et al. 2023

IJMS

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The intestine is considered to be a vital digestive organ to absorb nutrients and is the largest immune organ, while numerous microorganisms coexist with the host. It is well known that the complex interactions between the gut microbiota and the host’s immune system inevitably affect the function of other organs, creating an “axis” between them. During the past few years, a new technique based mainly on microfluidics and cell biology has been developed to emulate the structure, function, and microenvironment of the human gut, called the “gut-on-chip”. This microfluidic chip provides insight into key aspects of gut function in health and disease, such as the gut–brain axis, gut–liver axis, gut–kidney axis, and gut–lung axis. In this review, we first describe the basic theory of the gut axis and the various composition and parameter monitoring of the gut microarray systems, as well as summarize the development and emerging advances in the gut–organ-on-chip, with a focus on the host-gut flora and nutrient metabolism, and highlight their role in pathophysiological studies. In addition, this paper discusses the challenges and prospects for the current development and further use of the gut–organ-on-chip platform.

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Relevance of organ(s)-on-a-chip systems to the investigation of food-gut microbiota-host interactions

Abstract: 2021): Relevance of organ(s)on-a-chip systems to the investigation of food-gut microbiota-host interactions, Critical Reviews in Microbiology,

Cited by 27 publications

References 238 publications

Emerging microfluidic technologies for microbiome research

Emerging microfluidic technologies for microbiome research

Quorum sensing in human gut and food microbiomes: Significance and potential for therapeutic targeting

The Gut–Organ-Axis Concept: Advances the Application of Gut-on-Chip Technology

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