CORRESPONDENCErole of identifying and treating the precipitating factor along with active treatment with specific drug therapy forms the backbone of management. In both groups, general treatment (i.e., identification and treating the precipitant along with using drug therapy with lactulose and rifaximin) was similar. The only difference was the study drug under investigation, which was LOLA in one group and placebo in the other.Sample size in our study was calculated based on results of HE in previous studies on LOLA, lactulose, and the combination of lactulose plus rifaximin.