Relevance of Pulmonary Alveolar Echinococcosis

Aydın, Yener; Oğul, Hayri; Topdağı, Ömer; Ulaş, Ali Bilal; Sade, Recep; Öztürk, Gürkan; Korkut, Ercan; Aksungur, Nurhak; Şener, Ebru; Can, Fatma Kesmez; Araz, Ömer; Alper, Fatih; Eroğlu, Atilla

doi:10.1016/j.arbres.2019.07.014

Cited by 11 publications

(9 citation statements)

References 19 publications

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“…However, in 17.7% of patients, both routes were identified. Moreover, in 55.9% of the patients with pulmonary involvement, the lesions were located bilaterally [ 14 ]. Therefore, similarly to the TNM staging system used in cancer, PNM staging is used in AE, where P indicates primary liver location, N describes if the parasite invades surrounding structures, and M is for metastasis [ 15 ].…”

Section: Discussionmentioning

confidence: 99%

Basic Operative Tactics for Pulmonary Echinococcosis in the Era of Endostaplers and Energy Devices

et al. 2023

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Human echinococcosis is a zoonotic infection caused by the larvae of the tapeworm species Echinococcus. The liver is the most common location for a primary echinococcosis. However, the parasite may bypass or spread from the liver to the lungs, causing primary or secondary pulmonary echinococcosis, respectively. Pulmonary echinococcosis is a clinically challenging condition in which anthelminthic regiments are important, but surgery has the central role in removing the cysts and preventing recurrences. Surgical treatment may involve cystotomy, enucleation, capitonnage, or atypical resections, which occasionally are in combination with hepatic procedures. The utilization of modern devices is greatly underdescribed in surgery for thoracic infections, even though these facilitate much of the work. Therefore, this article aims to describe pulmonary echinococcosis and the role of modern surgical devices in the treatment process. Furthermore, we report surgical treatment of three different cases of pulmonary echinococcosis. Surgeries of uncomplicated and ruptured hepatic or pulmonary cysts are described. Simple small pulmonary echinococcal lesions can be excised by endostaplers both for diagnostic and curative reasons. Larger cysts can be removed by energy devices unless large bronchial air leaks occur. Complicated cysts require treatment by more extensive techniques. Inexperienced surgeons should not abstain but should carefully decide preoperatively how to proceed.

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Section: Discussionmentioning

confidence: 99%

Basic Operative Tactics for Pulmonary Echinococcosis in the Era of Endostaplers and Energy Devices

et al. 2023

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“…It usually settles in the liver and develops as larvae [ 1 ]. They also travel through the bloodstream to other organs, including the brain [ 6 , 7 ], lungs [ 8 , 9 ], and bone tissue [ 10 , 11 ].…”

Section: Discussionmentioning

confidence: 99%

Massive sympathetic nerve infiltration in advanced hepatic alveolar echinococcosis: a case report and review of the literature

et al. 2022

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Background Alveolar echinococcosis is a zoonotic disease that mostly affects the liver, with vascular invasion and a protean clinical symptom. However, no reports of sympathetic nerve infiltration in hepatic alveolar echinococcosis have been reported. Here, we report a case of hepatic alveolar echinococcosis in a 33-year-old man. In this end-stage case, the lesion was heavily involved in the large vessels and biliary tract, and immunohistochemistry also incidentally revealed extensive nerve infiltration in the specimens after surgical treatment. Subsequently, neural classification was identified. Case presentation We herein report a case of advanced hepatic alveolar echinococcosis with macrovascular invasion and sympathetic nerve infiltration. In this case, inferior vena cava (IVC), the portal vein and bile duct were infiltrated. Ultimately, according to our experience, ex vivo liver resection and autotransplantation (ELRA) was the optimal treatment way to perform for this unresectable patient. Samples were collected from normal liver tissue, junction tissue and the lesion. Hematoxylin–eosin (HE) staining was used to confirm the diagnosis. Neural infiltration was observed by immunohistochemical staining with protein gene product 9.5 (PGP9.5). Fluorescence colocalization was determined with PGP9.5 and tyrosine hydroxylase (TH). These results suggest that a large amount of sympathetic nerve infiltration occurred at the junction. Conclusion This study suggests that advanced hepatic alveolar echinococcosis shows infiltrating growth, often invades the large vessels and biliary ducts, and may be accompanied by sympathetic nerve infiltration.

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“…Alveolar echinococcosis is an endemic zoonosis that is common in non-tropical regions of the world, especially in the northern hemisphere. It is also seen mainly in the Eastern Anatolia Region in Turkey ( 2 ). The disease occurs when people consume food contaminated with eggs excreted in the feces of EM-infected carnivorous final-host animals such as wild cats, foxes, and rodents ( 3 ).…”

Section: Introductionmentioning

confidence: 99%

Serological Screening of Patients Diagnosed with Alveolar Echinococcus Disease in Their Home Regions

Akkaş¹,

Uslu²,

Yılmaz³

et al. 2022

IJPA

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Background: We aimed to determine the prevalence of Alveolar echinococcusis using ELISA in our region, to perform the specific differentiation of species by using the Western Blott method, to diagnose and treat this disease effectively in early periods, and to inform the patients about the results quickly. Methods: From the provinces of Erzurum, Kars, Ardahan, Iğdır, Ağrı and Erzincan in the Eastern Anatolia Region, Turkey in August-September 2017, blood samples were provided from 305 participants (volunteer patients and their relatives), including 151 females (49.50%), whose ages ranged between 6-85 yr and were diagnosed as Alveolar echinococcosis (AE) and operated in concerned clinics. Results: EIgG ELISA was determined as positive in 29 (9.5%) participants, including 17 (11.3%) females and 12 (7.8%) males. In addition, Em2-Em18 ELISA was also determined as positive in 15 (4.9%) participants, including 9 (6%) females and 6 (3.9%) males. Tweleve (3.94 %) of these findings were observed as positive in terms of both tests. Through the verification done by Anti-EWB IgG, Echinococcus multilocularis (EM) was identified in 7 (21.9%) of the female participants, E. granulosus (EG) in 1 (3.1%), and both parasites in 2 (6.2%). For male participants, EM was determined in 3 (9.3%) of them, EG in 1 (3.1%), and both parasites in 1 (3.1%). Conclusion: AE continues to threaten public health in the region. In families where AE is detected positive, the reason for disease is based on nutrition; thus, it will be proper to check up all family members in the terms of infection.

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Relevance of Pulmonary Alveolar Echinococcosis

Cited by 11 publications

References 19 publications

Basic Operative Tactics for Pulmonary Echinococcosis in the Era of Endostaplers and Energy Devices

Basic Operative Tactics for Pulmonary Echinococcosis in the Era of Endostaplers and Energy Devices

Massive sympathetic nerve infiltration in advanced hepatic alveolar echinococcosis: a case report and review of the literature

Serological Screening of Patients Diagnosed with Alveolar Echinococcus Disease in Their Home Regions

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