Relevance of the bioavailable fraction of DDT and its metabolites in freshwater sediment toxicity: New insight into the mode of action of these chemicals on Dictyostelium discoideum

Sforzini, Susanna; Governa, D.; Boeri, Marta; Oliveri, Laura; Oldani, A.; Vago, Fabio; Viarengo, Aldo; Borrelli, Raffaella

doi:10.1016/j.ecoenv.2016.06.013

Cited by 6 publications

(8 citation statements)

References 41 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Biodegradable film fragments added to soil are generally considered safe from a toxicological standpoint. For example, Sforzini S et al ( Sforzini et al, 2016 ) tested a starch copolyester blend, Mater-Bi R, showing no ecotoxicity effects, and Ardisson GB et al ( Ardisson et al, 2014 )verified experimentally that biodegradable film fragments did not negatively affect nitrification potential effect.…”

Section: Resultsmentioning

confidence: 99%

Past, present, and future perspectives of biodegradable films for soil: A 30-year systematic review

Sun

Yang²,

Shi³

et al. 2022

Front. Bioeng. Biotechnol.

View full text Add to dashboard Cite

Based on the Web of Science Core Collection (WOSCC) database, the academic works published in the past 30 years on biodegradable films for soil were analyzed. In order to ensure the rigor of this experiment, this paper is based on the mathematical double matrix model VOS Viewer software and CiteSpace software. This work shows that publications of biodegradable films for soil are increasing year by year; polymer science is the hottest subject in the field of biodegradable films for soil; China and the United States are the countries with the most significant number of publications in this field, has an important position; Washington State University is the most published institution. This study further identifies and reveals the essential characteristics, research strength, knowledge structure, main research fields, and research hotspots in the late stage of the field of biodegradable films for soil and introduces the Activity Index (AI) and the Attractive Index (AAI), thereby assessing trends and performance in different countries. The paper also further illustrates the importance of biodegradable films by presenting field trials using biodegradable films on different plants. The research in the field of biodegradable films for soil is divided into four categories: “The research field of degradation,” “The effect of biodegradable film on soil,” “Performance and mechanism of the biodegradable film,” and “Effects of biodegradable film on crop growth and development.”. The study can be seen as a microcosm of the development of biodegradable films for soils, which will help researchers quickly identify their general patterns. Readers can better understand the changes and development trends in this field in the past 30 years and provide references for future research.

show abstract

Section: Resultsmentioning

confidence: 99%

Past, present, and future perspectives of biodegradable films for soil: A 30-year systematic review

Sun

Yang²,

Shi³

et al. 2022

Front. Bioeng. Biotechnol.

View full text Add to dashboard Cite

show abstract

“…25 In this sense, D. discoideum is a wellestablished model organism widely used for studying numerous aspects of eukaryotic cell biology 23 and has been used to study the effect of environmental contaminants. 24 The characterization of D. discoideum behavior during the described stages of its life cycle can yield valuable information about its potential toxicity in the presence of a specific compound. Several studies have employed different strategies to test the toxicity of different compounds.…”

Section: Introductionmentioning

confidence: 99%

“…In this sense, it has been demonstrated that D. discoideum amoebic cells are sensitive to nonessential heavy metals (e.g., mercury and cadmium) and organic xenobiotic compounds (e.g., benzopyrene and DDT). 24 Therefore, they have been successfully used to assess the quality of freshwater environments. Amaroli et al 26,27 have been studying the toxicity of some pesticides in the D. discoideum model.…”

Section: Introductionmentioning

confidence: 99%

Exploring the Properties of Unilamellar Vesicle Bilayers Formed by Ionic Liquid Surfactants for Future Applications in Nanomedicine

Lépori,

Luna,

Challier

et al. 2024

J. Phys. Chem. B

View full text Add to dashboard Cite

Two ionic liquids (ILs) with amphiphilic properties composed of 1-butyl-3-methylimidazolium dioctylsulfosuccinate (bmim-AOT) and 1-hexyl-3-methylimidazolium dioctylsulfosuccinate (hmim-AOT) form unilamellar vesicles spontaneously simply by dissolving the IL-like surfactant in water. These novel vesicles were characterized using two different and highly sensitive fluorescent probes: 6-propionyl-2-(dimethylaminonaphthalene) (PRODAN) and trans-4-[4-(dimethylamino)-styryl]-1-methylpyridinium iodide (HC). These fluorescent probes provide information about the physicochemical properties of the bilayer, such as micropolarity, microviscosity, and electron-donor capacity. In addition, the biocompatibility of these vesicles with the blood medium was evaluated, and their toxicity was determined using Dictyostelium discoideum amoebas. First, using PRODAN and HC, it was found that the bilayer composition and the chemical structure of the ions at the interface produced differences between both amphiphiles, making the vesicles different. Thus, the bilayer of hmim-AOT vesicles is less polar, more rigid, and has a lower electrondonor capacity than those made by bmim-AOT. Finally, the results obtained from the hemolysis studies and the growth behavior of unicellular amoebas, particularly utilizing the D. discoideum assay, showed that both vesicular systems do not produce toxic effects up to a concentration of 0.02 mg/mL. This elegant assay, devoid of animal usage, highlights the potential of these newly organized systems for the delivery of drugs and bioactive molecules of different polarities.

show abstract

“…Biomarker responses in lower complexity organisms may serve as early warning signals of the effects of bioavailable toxic chemicals before manifestation of more severe pathological conditions 14 . DDTs can affect the redox status and reproduction of cells, and cause genotoxic effects 15–18 .…”

Section: Introductionmentioning

confidence: 99%

“…DDTs can affect the redox status and reproduction of cells, and cause genotoxic effects 15–18 . Exposure of Dictyostelium discoideum amoebae to 732.5 μg/L DDX (p,p’-DDT, p,p’-DDD and p,p’-DDE) in water solution, reactive oxygen species (ROS) increased and the glutathione (GSH) content significantly decreased 14 ; however, no harmful or sublethal effects were observed in amoebae in sediments containing the same level of DDX (732.5 μg/kg) 14 .…”

Section: Introductionmentioning

confidence: 99%

Assessment of tissue-specific accumulation, elimination and toxic effects of dichlorodiphenyltrichloroethanes (DDTs) in carp through aquatic food web

Liu

Tian

et al. 2017

Sci Rep

View full text Add to dashboard Cite

Microcosms containing DDT spiked-sediment, Tubifex tubifex and carp (Cyprinus carpio) were constructed to simulate a freshwater system. The accumulation, elimination and toxic effects of DDT (p,p’-DDT, o,p’-DDT), and its metabolites DDD (p,p’-DDD, o,p’-DDD) and DDE (p,p’-DDE, o,p’-DDE) were studied in T. tubifex and carp. Tissue/organ distributions of DDTs were also investigated in carp. The bioaccumulation and elimination of DDT differed in T. tubifex, carp and its tissues/organs. Unimodal or bimodal distributions were observed, and the concentrations of DDT metabolites (DDD and p,p’-DDE) increased over time. The carp organ with the highest concentrations of DDTs (DDT, DDD and DDE) was the gill. The largest mass distribution of DDTs was also in gill, followed by muscle and gastrointestinal tract. Maximum levels of DDTs in whole carp and carp muscle were 161 and 87 ng/g, respectively; therefore, the levels of DDTs observed in carp in this study were insufficient to constitute a health concern if present in fish for human consumption. Significant changes were observed in some biomarkers, including superoxide dismutase, catalase, glutathione-S-transferase, glutathione, and carboxylesterase, in T. tubifex and carp tissues during DDT exposure. Tissue-specific accumulation of DDTs in carp can be a key indicator of exposure to environmentally relevant concentrations.

show abstract

Relevance of the bioavailable fraction of DDT and its metabolites in freshwater sediment toxicity: New insight into the mode of action of these chemicals on Dictyostelium discoideum

Cited by 6 publications

References 41 publications

Past, present, and future perspectives of biodegradable films for soil: A 30-year systematic review

Past, present, and future perspectives of biodegradable films for soil: A 30-year systematic review

Exploring the Properties of Unilamellar Vesicle Bilayers Formed by Ionic Liquid Surfactants for Future Applications in Nanomedicine

Assessment of tissue-specific accumulation, elimination and toxic effects of dichlorodiphenyltrichloroethanes (DDTs) in carp through aquatic food web

Contact Info

Product

Resources

About