Relevance of the Cytogenetic Status in Acute Leukemia in Adults2

Gunz, F. W.; Bach, B.; Crossen, Peter E.; Mellor, Johnalyn E.L.; Singh, Sukhchain; Vincent, Paul

doi:10.1093/jnci/50.1.55

Cited by 38 publications

(3 citation statements)

References 0 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…T h e present report deals with the results of cytogenetic studies with quinacrine fluorescence and C' liemsa staining of bone marrow and/or blood cells from these 38 patients with AhfL. AM L, 8 lized on bone marrow material obtained from the sternum or iliac crest and/or peripheral blood cells of 38 patients (36 patients previously unreported) with A,ML hospitalized at or attending the clinics of R P M I . T w o of the patients originated from a previous series of A M L patients35 studied cytogenetically with conventional staining.…”

mentioning

confidence: 99%

Chromosomes and causation of human cancer and leukemia. XVII.Banding studies in acute myeloblastic leukemia (AML)

Oshimura

Hayata

Kakati

et al. 1976

Cancer

115

View full text Add to dashboard Cite

Chromosomes were studied in the bone marrow and/or blood cells from 38 patients with acute myeloblastic leukemia (AML). The initial analysis with conventional Giemsa staining revealed that 16 of the 38 patients with AML studied had chromosomal abnormalities. The cells of these 38 patients (16 with abnormal karyotypes and 22 with normal karyotypes) were re-examined with Q- and G-banding techniques. Twenty-two patients with conventionally stained normal karyotypes did not show any abnormalities, even with banding techniques. Three cases had a common translocation between the long arm of No. 8 and No. 21, i.e., [t(8;21)(q22;q22)], the so-called prototypic karyotype. Two cases had a 45, XX,-21 karyotype; and three cases had trisomy of the long arm of chromosome No. 1. The banding patterns revealed that in two of the three latter cases, the presence of the trisomy of the long arm of No. 1 apparently occurred late in the disease. Therefore, it is possible that the trisomy of the long arm of No. 1 might bear a relationship to selective growth advantage of the leukemic cells in some cases with AML. The presence of extra No. 8 and No. 9 chromosomes and deletion of the long arm of No. 7, frequently reported in several leukemic disorders, were also found in the present cases, but with other chromosomal abnormalities. Chromosomes No. 6,No. 15,No. 19,No. 20, and X were not involved in any structural and/or numerical changes. The present data suggest that some chromosomal changes are nonrandom in AML and that further chromosomal studies may lead to a division of AML patients into subgroups on the basis of their karyotypes.

show abstract

mentioning

confidence: 99%

Chromosomes and causation of human cancer and leukemia. XVII.Banding studies in acute myeloblastic leukemia (AML)

Oshimura

Hayata

Kakati

et al. 1976

Cancer

115

View full text Add to dashboard Cite

show abstract

“…Die prognostische Relevanz von Karyotypveränderungen (normal vs. aberrant) wurde bereits Anfang der 70er Jahre festgestellt [8,9]. Inzwischen kann man die AML jedoch in deutlich mehr prognostisch bedeutsame zytogenetische Subgruppen aufteilen.…”

Section: Zytogenetikunclassified

Diagnostik, Klassifikation und Prognosefaktoren der akuten myeloischen Leukämie

Heilmeier¹,

Buske²,

Spiekermann³

et al. 2007

Med Klin

View full text Add to dashboard Cite

show abstract

“…Chromosome studies in acute leukaemia preceding the introduction of chromosome banding techniques have demonstrated a wide range of karyotypes in bone-marrow cells of leukaemic patients. When abnormalities were detected the cells were found to be predominantly hyperdiploid in acute lymphoblastic leukaemia (ALL), hypodiploid or hyperdiploid in acute myeloid leukaemia (AML) and in the triploid range in erythroleukaemia (Kiossoglou et a1 1965, Sandberg et a1 1968, Whang-Peng et a1 1969, Whang-Peng et al 1970, Hart et a1 1971, Jensen 1971, Gunz et al 1973, Fitzgerald et a1 1973. In about half the cases, no chromosomal abnormalities were detected.…”

mentioning

confidence: 99%

Chromosome Banding Studies in Acute Leukaemia at Diagnosis

Lawler

Walker

Summersgill

et al. 1975

Scandinavian Journal of Haematology

View full text Add to dashboard Cite

Cytogenetic study by a chromosome banding technique has been attempted in 93 cases of acute leukaemia at diagnosis. Banding patterns were difficult t o visualise in the bone-marrow chromosomes of patients with acute leukaemia because of the fuzzy appearance of the fixed metaphases. The proportion of patients with abnormal chromosomes was higher in acute lymphoblastic (ALL) than in acute myeloid (AML) leukaemia. Abnormalities were present in all cases of other cytological types. Hyperdiploidy was the most commonly found numerical error in both ALL and AML but a larger proportion of patients with ALL had hyperdiploidy in more than 30 % of the cells. In ALL it was generally found that the higher the frequency of hyperdiploidy the greater was the number of chromosomm per cell. Hypodiploidy not attributable to random losses was found in only 6 patients. Clones identified by rearranged or marker chromosomes were found in all types of leukaemia. Clones marked by a 7q-chromosome, in which the break point was the same, were identified in 1 adult with ALL and 2 children with AML. The high frequency of randomly distributed chromosomal breakage found in the bone-marrow chromosomes of a high proportion of the patients may be related to the disease process.

show abstract

Relevance of the Cytogenetic Status in Acute Leukemia in Adults2

Cited by 38 publications

References 0 publications

Chromosomes and causation of human cancer and leukemia. XVII.Banding studies in acute myeloblastic leukemia (AML)

Chromosomes and causation of human cancer and leukemia. XVII.Banding studies in acute myeloblastic leukemia (AML)

Diagnostik, Klassifikation und Prognosefaktoren der akuten myeloischen Leukämie

Chromosome Banding Studies in Acute Leukaemia at Diagnosis

Contact Info

Product

Resources

About