Relevance of vitamin D3 in COVID-19 infection

Afshan, Falaque Ul; Nissar, Bushra; Chowdri, Nisar Ahmad; Ganai, Bashir Ahmad

doi:10.1016/j.genrep.2021.101270

Cited by 11 publications

(5 citation statements)

References 128 publications

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“…The expression of CYP27B1 and synthesis of 1α,25(OH)2D3 play a crucial role in the development of APCs (dendritic cells and macrophages), indicating a direct involvement of vitamin D3 in the body's immune system. 25 The 1,25(OH)2D, a form of vitamin D, is produced and acts on keratinocytes in the oral epithelium. 26 This signaling affects the growth, differentiation, and death of these cells, as well as local immune responses.…”

Section: Discussionmentioning

confidence: 99%

Role of 1,25(OH)2D On Cytochromes CYP27A1 and CYP27B1 in Periodontitis: A Clinical Study

Thanoon,

Al Mashhadane

2024

Pharmacogn J.

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Background: Vitamins have a great impact on metabolis. Aims: To determine the role of 1,25(OH)2D On Cytochromes CYP27A1 and CYP27B1 in Periodontitis. Material and Method: The investigation was carried out on 45 participants of ages within the range of (30-45 years) who were attending the private dental clinics. Diagnosis of chronic periodontitis was established depending on dental history, clinical examinations (periodontal indices). All participants were examined by the same dentist. They were classified into three groups: Group 1 (control negative): (15) participants with normal serum vitamin D3 level and with pocket depth ≤3 mm, good oral health and normal periodontal tissues and no previous history of periodontal diseases. Group 2 (control positive): (15) participants with normal serum vitamin D3 level and periodontitis with pocket depth ≥5 mm, they received placebo medication orally, Group3(treatment): (15) participants with vitamin D3 deficiency (below 30 IU), and periodontitis with pocket depth ≥5 mm, they received oral Vitamin D3 fast acting liquid soft gel capsule 2000 IU /day for 3 months. 3 blood samples were taken from each participant at 0,45,90 days, for research examinations. CYP27A1, CYP27B1 serum levels was measured for each sample in three groups by ELISA kit. Result: there was a highly significant reduction in CYP27A1 serum level in the treatment group at the ninety days of the study while there was no significant elevation CYP27B1 serum level in all groups during 45,90 days of the study. Conclusion:The present study suggested that the 1,25(OH)2D has effects on serum levels of both Cytochromes CYP27A1 and CYP27B1 and this was associated with periodontitis.

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Section: Discussionmentioning

confidence: 99%

Role of 1,25(OH)2D On Cytochromes CYP27A1 and CYP27B1 in Periodontitis: A Clinical Study

Thanoon,

Al Mashhadane

2024

Pharmacogn J.

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“…As a result of its immunomodulatory effects, vitamin D has emerged as a micronutrient of interest in the prevention and care of patients with COVID-19 [58]. Observational studies have found associations with low levels of circulating 25-OH D, defined as <20 ng/mL, and higher test positivity rates for COVID-19 [59].…”

Section: Micronutrients and Severity Of Respiratory Infections 21 Vit...mentioning

confidence: 99%

Micronutrient Deficiency as a Confounder in Ascertaining the Role of Obesity in Severe COVID-19 Infection

Chu

Surampudi

et al. 2022

IJERPH

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Food insecurity in the United States has been exacerbated due to the socioeconomic strain of the coronavirus disease 2019 (COVID-19) pandemic. Populations experiencing poverty and, as a consequence, food insecurity in the United States are disproportionately affected by obesity, which was identified early in the pandemic as a major risk factor for increased susceptibility to COVID-19 infection and mortality. Given the focus on obesity and its role in immune dysregulation, it is also important to note the role of micronutrient deficiency, another sequalae of food insecurity. Micronutrients play an important role in the ability of the immune system to mount an appropriate response. Moreover, OBESE individuals are more likely to be micronutrient deficient. This review will explore the role of micronutrients, vitamin A, vitamin D, vitamin C, and zinc in respiratory immunity and COVID-19 and how micronutrient deficiency may be a possible confounder in obesity’s association with severe outcomes. By illuminating the role of micronutrients in COVID-19, this paper expands the discussion from food insecurity and obesity to include micronutrient deficiency and how all of these interact in respiratory illnesses such as COVID-19.

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“…Vitamin D has been studied extensively before the pandemic as a negative marker of inflammation; that is, in patients who previously had normal 25(OH)D3 levels, an inflammatory process can make vitamin D levels decrease [13,14].…”

Section: Serum 25(oh)d3 As a Negative Marker Of Inflammation In The P...mentioning

confidence: 99%

Association between low serum vitamin D and increased mortality and severity due to COVID-19: reverse causality?

Oscanoa

Ghashut²,

Carvajal³

et al. 2022

Disaster Emerg Med J

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Relevance of vitamin D3 in COVID-19 infection

Cited by 11 publications

References 128 publications

Role of 1,25(OH)2D On Cytochromes CYP27A1 and CYP27B1 in Periodontitis: A Clinical Study

Role of 1,25(OH)2D On Cytochromes CYP27A1 and CYP27B1 in Periodontitis: A Clinical Study

Micronutrient Deficiency as a Confounder in Ascertaining the Role of Obesity in Severe COVID-19 Infection

Association between low serum vitamin D and increased mortality and severity due to COVID-19: reverse causality?

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