Relevance Study on Cerebral Infarction and Resistin Gene Polymorphism in Chinese Han Population

Yan, Aijuan; Cai, Gaoyu; Fu, Ningzhen; Yan, Feng; Sun, Jialan; Maimaiti, Yiming; Zhou, Weijun; Fu, Yi

doi:10.14336/ad.2016.0201

Cited by 6 publications

(4 citation statements)

References 42 publications

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“…High serum levels reportedly associate with T2D, coronary artery disease (CAD) and inflammatory diseases 1,3,5,33–35 . Although in GWAS studies the two RETN SNPs have not been found yet to be directly linked to these diseases 58–60 , they have been associated already with rheumatoid arthritis 61 and cerebral infarction 62 . Moreover, in individuals of Chinese ethnicity, where the two SNPs are the predominant variants regulating the gene expression, the A-A haplotype (associated with high RETN levels) seems to promote the elimination of pathogens such as hepatitis C virus 63 .…”

Section: Discussionmentioning

confidence: 99%

Resistin expression in human monocytes is controlled by two linked promoter SNPs mediating NFKB p50/p50 binding and C-methylation

Kumar

Lee

Puan

et al. 2019

Sci Rep

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Resistin is a key cytokine associated with metabolic and inflammatory diseases. Especially in East Asian populations, the expression levels are strongly influenced by genetic polymorphisms. Mechanisms and functional implications of this genetic control are still unknown. By employing reporter assays, EMSA, inhibition studies, bisulphite sequencing, ChIP-Seq and gene-editing we show that the p50/p50 homodimer known to act as repressor for a number of pro-inflammatory genes plays a central role in the genetic regulation of resistin in monocytes along with promoter methylation. In the common RETN haplotype p50/p50 constitutively dampens the expression by binding to the promoter. In an Asian haplotype variant however this interaction is disrupted by the A allele of rs3219175. The SNP is in very close linkage to rs34861192, a CpG SNP, located 280 bp upstream which provides an allele-specific C-methylation site. rs34861192 is located in a 100 bp region found to be methylated in the common but not in the Asian haplotype, resulting in the latter having a higher basal expression, which also associates with elevated histone acetylation (H3K27ac). Genotype associations within cohort data of 200 East Asian individuals revealed significant associations between this haplotype and the plasma levels of factors such as TGF-b, S100B, sRAGE and IL-8 as well as with myeloid DC counts. Thus, the common RETN haplotype is tightly regulated by the epigenetic mechanism linked to p50/p50-binding. This control is lost in the Asian haplotype, which may have evolved to balance the antagonistic RETN effects on pathogen protection vs. metabolic and inflammatory disease induction.

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Section: Discussionmentioning

confidence: 99%

Resistin expression in human monocytes is controlled by two linked promoter SNPs mediating NFKB p50/p50 binding and C-methylation

Kumar

Lee

Puan

et al. 2019

Sci Rep

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“…As shown in Figure 1 , the structure of a typical CT imaging detection system is shown in the figure above. The system is composed of a radiation source, a high-voltage power supply, a radiation imaging device, a computer, and a display [ 17 , 18 ]. The high-voltage power supply provides high-voltage to the ray source to drive the ray tube to generate rays.…”

Section: Thrombolytic Efficacy and Prognostic Methodsmentioning

confidence: 99%

[Retracted] Observation of the Effect of Nursing BPR on Thrombolytic Efficacy and Prognosis of Patients with Cerebral Infarction Based on CT Images

Wang

Xing

Zhang

et al. 2022

Contrast Media & Molecular Imaging

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Cerebral infarction has become the main cause of death among Chinese residents, especially ischemic cerebral infarction. The existing CT technology is not very effective for the detection of cerebral infarction, and some angiography has problems such as blurring and shadowing. In order to understand the treatment methods and effects of patients with cerebral infarction, this article observes the effect of nursing BPR on thrombolytic efficacy and prognosis of patients with cerebral infarction based on CT images. The patients were divided into thrombolytic group and nonthrombolytic group, and a simple rating scale was used to assess the motor function of the patients' limbs, and the stroke scale was used to assess the patient’s neurological function. Compare the baseline data, the time of admission, 24 hours and 7 days, the scores before and after treatment, and the ratio between the two groups. According to the monitoring, record each time point. The analysis of the occurrence of primary endpoint was events and secondary endpoint events and risk factors affecting limb motor function. The results of the study found that, based on the computer scanning observation of nursing BPR, compared with the traditional model, the patient's bleeding was significantly reduced, and the time required for nursing was also reduced by more than 50% compared with the traditional model. Compared with the traditional nursing model, the satisfaction of patients with the BPR nursing model is nearly 40% higher than that of the traditional nursing model. This shows that the observation of thrombolytic effect in patients with cerebral infarction based on computed tomography and BPR nursing can produce good therapeutic effects.

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“…In addition to coronary artery disease and myocardial infarction, insulin resistance-related genetic variants were also associated with increased risk of CIs [ 76 ]. Specifically, GG genotypes of rs3219175 and rs34861192 of the Resistin ( RETN ) gene, encoding a hormone that links obesity to diabetes mellitus, were associated with increased risk of small artery ischemic stroke [ 77 ]. The Apolipoprotein A-I ( APOA1 ) gene encodes the main protein component of high-density lipoprotein in plasma, which facilitates the function of cholesterol excretion.…”

Section: Resultsmentioning

confidence: 99%

Genetic Variants behind Cardiovascular Diseases and Dementia

Chen

2020

Genes

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Cardiovascular diseases (CVDs) and dementia are the leading causes of disability and mortality. Genetic connections between cardiovascular risk factors and dementia have not been elucidated. We conducted a scoping review and pathway analysis to reveal the genetic associations underlying both CVDs and dementia. In the PubMed database, literature was searched using keywords associated with diabetes mellitus, hypertension, dyslipidemia, white matter hyperintensities, cerebral microbleeds, and covert infarctions. Gene lists were extracted from these publications to identify shared genes and pathways for each group. This included high penetrance genes and single nucleotide polymorphisms (SNPs) identified through genome wide association studies. Most risk SNPs to both diabetes and dementia participate in the phospholipase C enzyme system and the downstream nositol 1,4,5-trisphosphate and diacylglycerol activities. Interestingly, AP-2 (TFAP2) transcription factor family and metabolism of vitamins and cofactors were associated with genetic variants that were shared by white matter hyperintensities and dementia, and by microbleeds and dementia. Variants shared by covert infarctions and dementia were related to VEGF ligand–receptor interactions and anti-inflammatory cytokine pathways. Our review sheds light on future investigations into the causative relationships behind CVDs and dementia, and can be a paradigm of the identification of dementia treatments.

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Relevance Study on Cerebral Infarction and Resistin Gene Polymorphism in Chinese Han Population

Cited by 6 publications

References 42 publications

Resistin expression in human monocytes is controlled by two linked promoter SNPs mediating NFKB p50/p50 binding and C-methylation

Resistin expression in human monocytes is controlled by two linked promoter SNPs mediating NFKB p50/p50 binding and C-methylation

[Retracted] Observation of the Effect of Nursing BPR on Thrombolytic Efficacy and Prognosis of Patients with Cerebral Infarction Based on CT Images

Genetic Variants behind Cardiovascular Diseases and Dementia

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