Relevant Oncogenic Viruses in Veterinary Medicine: Original Pathogens and Animal Models for Human Disease

Truyen, Uwe; Löchelt, Martin

doi:10.1159/000092968

Cited by 11 publications

(7 citation statements)

References 66 publications

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“…Human T-Cell Lymphotropic Virus-1). Wirusy onkogenne zaangażowane w powstawanie nowotworów zawierają materiał genetyczny w formie RNA lub DNA i należą do różnych grup taksonomicznych (Tabela 1) [3][4][5][6].…”

Section: Wprowadzenieunclassified

Wirusy onkogenne a nowotwory

et al. 2021

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Wirusy onkogenne (onkowirusy) są zaangażowane w powstawanie około 12% nowotworów u ludzi. Obecnie wirusy, o których wiadomo, że powodują raka, to wirusy zapalenia wątroby typu C i B (HCV i HBV), wirusy brodawczaka ludzkiego (HPV), wirus polyoma komórek Merkla (MCV), ludzki herpeswirus-8 (HHV-8) i ludzki wirus limfotropowy komórek T (HTLV-1). Wirusy nie są jednak pełnymi kancerogenami i w procesie transformacji nowotworowej odgrywają różną rolę. Onkowirusy mogą bezpośrednio zakłócać funkcjonowanie genów kodujących komórkowe białka regulatorowe w wyniku insercji własnego genomu do genomu komórkowego. Mają także własne geny kodujące białka, które zaburzają regulację procesów komórkowych lub zawierają onkogeny wirusowe v-onc, które mogą brać udział bezpośrednio w rozwoju procesu nowotworowego.

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Section: Wprowadzenieunclassified

Wirusy onkogenne a nowotwory

et al. 2021

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“…For instance, porcine dissections were used to write the earliest anatomy textbooks around 900 A.D. [ 1 ], while rodents have been employed as models for cancer research for years [ 2 ]. Over time, animal models have yielded many general concepts in molecular oncology and hypotheses on the role of oncoviruses in tumor development [ 3 ]. Rous sarcoma virus, discovered by Rous in the early twentieth century, was the first oncogenic virus [ 4 , 5 ] and a landmark in the oncovirus field.…”

Section: Introductionmentioning

confidence: 99%

“…Subsequently, it was discovered that oncoviruses are prevalent among both animals and humans and cause about 12% of human cancers [ 7 – 10 ]. Despite many similarities between animals and humans, there remain intrinsic differences that must be considered when they are used in cancer research [ 3 ]. However, the use of animals as models for human diseases is a crucial cornerstone of cancer research, both in the past and present, especially for prevention and therapy [ 3 ].…”

Section: Introductionmentioning

confidence: 99%

Exploring the link between viruses and cancer in companion animals: a comprehensive and comparative analysis

Parisi

Fonti

Millanta

et al. 2023

Infect Agents Cancer

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Currently, it is estimated that 15% of human neoplasms globally are caused by infectious agents, with new evidence emerging continuously. Multiple agents have been implicated in various forms of neoplasia, with viruses as the most frequent. In recent years, investigation on viral mechanisms underlying tumoral transformation in cancer development and progression are in the spotlight, both in human and veterinary oncology. Oncogenic viruses in veterinary medicine are of primary importance not only as original pathogens of pets, but also in the view of pets as models of human malignancies. Hence, this work will provide an overview of the main oncogenic viruses of companion animals, with brief notes of comparative medicine.

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“…In humans, a number of viruses are highly associated with tumor development and a subset of these resemble MDV infection and MD progression in chickens through numerous features of their viral genome structure and/or virus-induced disease pathogenesis [33][34][35]. Specifically, Epstein-Barr virus (EBV), hepatitis B virus, human papilloma virus-18 and human herpesvirus-6 (HHV-6) are associated with a number of human cancers [36][37][38][39][40][41][42][43].…”

Section: Introductionmentioning

confidence: 99%

“…Furthermore, HHV-6 integrates into human telomeric DNA and contains human telomeric repeats within its genome [44][45][46], while EBV integrates into the host genomic DNA in a subset of EBV-associated cancers [47][48][49][50][51][52][53]. The similarities between MDV and human oncogenic viruses, particularly herpesviruses, highlight the importance of chicken as a medical model organism in the study of human virus-induced diseases and cancers [35,54].…”

Section: Introductionmentioning

confidence: 99%

Marek’s Disease Virus Telomeric Integration Profiles of Neoplastic Host Tissues Reveal Unbiased Chromosomal Selection and Loss of Cellular Diversity during Tumorigenesis

Glass

Smith

Cheng

et al. 2021

Genes

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The avian α-herpesvirus known as Marek’s disease virus (MDV) linearly integrates its genomic DNA into host telomeres during infection. The resulting disease, Marek’s disease (MD), is characterized by virally-induced lymphomas with high mortality. The temporal dynamics of MDV-positive (MDV+) transformed cells and expansion of MD lymphomas remain targets for further understanding. It also remains to be determined whether specific host chromosomal sites of MDV telomere integration confer an advantage to MDV-transformed cells during tumorigenesis. We applied MDV-specific fluorescence in situ hybridization (MDV FISH) to investigate virus-host cytogenomic interactions within and among a total of 37 gonad lymphomas and neoplastic splenic samples in birds infected with virulent MDV. We also determined single-cell, chromosome-specific MDV integration profiles within and among transformed tissue samples, including multiple samples from the same bird. Most mitotically-dividing cells within neoplastic samples had the cytogenomic phenotype of ‘MDV telomere-integrated only’, and tissue-specific, temporal changes in phenotype frequencies were detected. Transformed cell populations composing gonad lymphomas exhibited significantly lower diversity, in terms of heterogeneity of MDV integration profiles, at the latest stages of tumorigenesis (>50 days post-infection (dpi)). We further report high interindividual and lower intraindividual variation in MDV integration profiles of lymphoma cells. There was no evidence of integration hotspots into a specific host chromosome(s). Collectively, our data suggests that very few transformed MDV+ T cell populations present earlier in MDV-induced lymphomas (32–50 dpi), survive, and expand to become the dominant clonal population in more advanced MD lymphomas (51–62 dpi) and establish metastatic lymphomas.

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Relevant Oncogenic Viruses in Veterinary Medicine: Original Pathogens and Animal Models for Human Disease

Cited by 11 publications

References 66 publications

Wirusy onkogenne a nowotwory

Wirusy onkogenne a nowotwory

Exploring the link between viruses and cancer in companion animals: a comprehensive and comparative analysis

Marek’s Disease Virus Telomeric Integration Profiles of Neoplastic Host Tissues Reveal Unbiased Chromosomal Selection and Loss of Cellular Diversity during Tumorigenesis

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