Due to the extremely rough working environment, aero-hydraulic pipes face serious dynamic failure problems in applications for practical engineering. This paper proposes a dynamic reliability and moment-independent global sensitivity analysis (GSA) method to evaluate the dynamic reliability and the effects of random input variables on the dynamic reliability of aero-hydraulic pipes. Based on the Miner criterion for the cumulative damage of structural fatigue, this paper establishes the dynamic reliability analysis method under the condition of double random vibration. In order to further analyze the influence of the uncertainty of each random variable of pipe on its dynamic reliability, a moment-independent global sensitivity index for dynamic reliability based on cumulative distribution function is proposed in this paper. The index can reflect the effects of random variables on dynamic reliability quantitatively. Based on the proposed GSA method of dynamic reliability, a sparse grid integral (SGI) method is introduced to solve the dynamic reliability and moment-independent global sensitivity index, with high computational efficiency. Finally, the effects of clamp supports, diameters, and curvature of curved pipe on the dynamic reliability and GSA are analyzed through a hydraulic piping example.