Reliability and feasibility of the six minute walk test in subjects with myotonic dystrophy

Kierkegaard, Marie; Tollbäck, Anna

doi:10.1016/j.nmd.2007.08.003

Cited by 90 publications

(85 citation statements)

References 232 publications

(360 reference statements)

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“…The distance increased by 4 m in the 2MWT, which is comparable to studies in participants with non-NMDs [5][6][7][8][9], but a learning effect in the 2MWT has never been investigated before in patients with NMDs. The increase of 11 m in the 6MWT from test to retest is a little lower than the 17-24 m reported in other NMD-studies [4][5][6][7][8][9][10][11][12][13][14][15]. The difference in walking variability across studies might be due to different sample sizes, neuromuscular diseases, disease severity and methods.…”

Section: Discussionmentioning

confidence: 68%

“…Previous studies have recommended to use the best of 2-3 6MWTs to eliminate the learning effect [1,4]. However, multiple tests are not always feasible to perform, and are time-consuming and fatiguing for patients.…”

Section: Discussionmentioning

confidence: 99%

“…The 6MWT is by many considered the gold standard to assess walking capability. However, variability due to a learning effect, motivation, fatigue and other day-to-day variations is well documented in the literature in patients with NMDs and nonNMDs in the 6MWT [1][2][3][4] and in non-NMDs in the 2MWT [5][6][7][8][9]. A learning effect is a better performance at retest, which is not due to improvement of the clinical condition, but instead a result of familiarization.…”

Section: Introductionmentioning

confidence: 99%

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The 2- and 6-Minute Walk Tests in Neuromuscular Diseases: Effect of Heart Rate Correction on the Learning Effect

Knak¹,

Andersen²,

Witting³

et al. 2017

Int J Phys Med Rehabil

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Objective: The 2-and 6-minute walk tests are common measures for evaluating walking ability, but reliability is weakened by a well-documented learning effect. Since heart rate is related to workload, any change in walking distance, which is unrelated to change in clinical function, should be reflected in a change in heart rate during walking. Therefore, the aim of the present study was to investigate test-retest reliability of the 2-and 6-minute walk tests with and without heart rate correction.Methods: Ninety-three adult patients (mean age of 53 years, range; 22-83 years) with 12 different neuromuscular diseases (myotonic dystrophy type 1, limb-girdle muscular dystrophy, facioscapulohumeral muscular dystrophy type 1, Charcot-Marie-Tooth disease, mitochondrial myopathy, Becker muscular dystrophy, spinobulbar muscular atrophy, sporadic inclusion body myositis, spinal muscular atrophy, myotonia congenita Thomsen disease, congenital myopathy, polymyositis) were recruited in the study. One 2-and 6-minute walk test was performed on two occasions, 1-2 weeks apart. Heart rate was monitored by a pulse-watch. Results:The distance walked increased significantly with repeated 2-and 6-minute walk tests (2-minute walk test increased by 4 ± 9 m and 6-minute walk test by 11 ± 26 m, p<0.001). Heart rate correction eliminated the learning effect in the 6-minute walk test (+0.01 m/heartbeat, p=0.84), but not in the 2-minute walk test (+0.03 m/ heartbeat, p=0.018). The same pattern of heart rate-correction in the 6-minute walk test was observed in all subgroup diagnoses. There was no difference in the learning effect between disease severities. Conclusion:Both the 2-and 6-minute walk tests are associated with a learning effect. The learning effect is eliminated when correcting for heart rate in the 6-minute walk test, but not in the 2-minute walk test. The results suggest using a heart rate corrected 6-minute walk test to weed out day-to-day variations that are not due to a real change in the patient's clinical condition.

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Section: Discussionmentioning

confidence: 68%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

The 2- and 6-Minute Walk Tests in Neuromuscular Diseases: Effect of Heart Rate Correction on the Learning Effect

Knak¹,

Andersen²,

Witting³

et al. 2017

Int J Phys Med Rehabil

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show abstract

“…The ability to walk at a specified distance is a quick, simple, and inexpensive way to evaluate physical function. Walking is also a critical important component of the quality of life because it is highly necessary to accomplish the daily life activities and reflects patient's capacity [151,152]. The validity study of the 2-min walk test has been conducted in neuromuscular diseases, and it was put to use in recent years since its period of implementation is short and it does not cause fatigue [153,154].…”

Section: Assessment Of Aerobic (Functional) Capacitymentioning

confidence: 99%

Neuromuscular Diseases and Rehabilitation

Demir¹

2017

Neurological Physical Therapy

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Neuromuscular diseases (NMDs) are a heterogeneous group of diseases that are inherited or acquired, resulting from an abnormality in the anterior horn motor cells, peripheral nerves, neuromuscular junctions, or muscles.In NMDs, evaluation is performed to monitor the progression of the disease, to determine the appropriate treatment methods, to investigate the efficacy of treatment methods, and to predict and prevent possible complications. Evaluation methods should include evaluation of respiratory functions, muscle testing, normal joint movement, evaluation of flexibility, evaluation of motor functions and functional capacities, functional posture, and gait analysis.The aim of physiotherapy approaches is to improve the quality of life of patients and their families. The rehabilitation program should include the protection of the functional level of the patient and the physical and psychological functions, increasing the physical and mental capacity of the patient, and slowing the progress of the disease symptoms. The rehabilitation program should include the preservation of muscle strength, an exercise program for the prevention of contractures, increasing respiratory function and aerobic capacity, gait and balance training, fall prevention, walking aid training, psychosocial approach, vocational counseling, ergotherapy processes and nutrition expert support.

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“…L'évaluation de la capacité à marcher est incontournable pour obtenir un portrait clinique dans la DM1. Le test de marche de 6 minutes est un outil dont la validité et la sensibilité ont été démontrées (Redelmeier et al, 1997;Rostagno et al, 2003;Alameri et al, 2007;Kierkegaard & Tollback, 2007;Rostagno & Gensini, 2008;de Souza et al, 2009;Pollentier et al, 2010). La procédure, assez simple, requiert que le sujet évalué marche sur la plus grande distance possible pendant une période de 6 minutes.…”

Section: 7unclassified

Évaluation de la capacité fonctionnelle chez des patients atteints de la dystrophie myotonique de type 1 /

Desjardins¹

2012

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Reliability and feasibility of the six minute walk test in subjects with myotonic dystrophy

Cited by 90 publications

References 232 publications

The 2- and 6-Minute Walk Tests in Neuromuscular Diseases: Effect of Heart Rate Correction on the Learning Effect

The 2- and 6-Minute Walk Tests in Neuromuscular Diseases: Effect of Heart Rate Correction on the Learning Effect

Neuromuscular Diseases and Rehabilitation

Évaluation de la capacité fonctionnelle chez des patients atteints de la dystrophie myotonique de type 1 /

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