The goal of the this study is to investigate the applicability of the teaching-learning based optimization (TLBO) algorithm for modeling seepage in embankment dams. The input parameters selected for the models to be built are the values of permeability (ks), van Genuchten's suitability parameters α and n, whose effect on seepage has been investigated over the years due to their uncertainties. The validity of the TLBO was compared with that of conventional regression analysis (CRA) methods. Both methods were utilized with different regression forms. The parameters chosen as input are modeled as random variables with a log-normal distribution, and total discharge (Q) was obtained. Four statistical indices, that is, root mean square error, mean absolute error, average relative error and coefficient of determination, were used to evaluate the performance of the models. The equations obtained using TLBO algorithms can predict the total discharge in embankment dams better than CRA. In addition, the reliability of TLBO has been demonstrated by conducting analyses using the outputs of CRA as a benchmark.