The ergonomic reliability assessment of interface design scheme for the passenger car is very practical to enhance driving safety performance. In addition, it can significantly reduce development costs and the development cycle of the new car. From the perspective of guiding the improvement of the central console interactive interface design of the passenger car, the most effective method to build the ergonomic reliability assessment method of the interactive interface is to evaluate and predict the human reliability objectively and subjectively and to design, feedback, and guide the design process of the ergonomic interface for the passenger car. Firstly, the questionnaire survey and the classification of ergonomic reliability analysis factors are analyzed to be put forward based on predecessors; the judgment layer factors and index layer factors of human-machine interaction interface in automobile central console are put forward. Secondly, entropy weight method (EWM) and multiple attribute decision-making (MADM) were used for objective evaluation and subjective evaluation, respectively. Thirdly, the interaction interfaces in central consoles of three different passenger cars are taken as examples; objective simulated experimental test based on entropy weight method and subjective scoring evaluation based on MADM were conducted, respectively. Besides, the objective evaluation and subjective evaluation are coupled by fuzzy comprehensive evaluation. Finally, to verify the effectiveness and rationality of the ergonomic reliability assessment method, human cognitive reliability experiments are made based on the data acquisition from the eye-tracking experiments.