Reliability and validity of the functioning assessment short test for older adults with bipolar disorder (FAST-O)

Orhan, Melis; Korten, Nicole; Kupka, Ralph; Oppen, Patricia van; Stek, Max L.; Vieta, Eduard; Schouws, Sigfried; Ballegooijen, Wouter van; Dols, Annemiek

doi:10.1186/s40345-020-00193-2

Cited by 15 publications

(15 citation statements)

References 22 publications

(36 reference statements)

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“…Regarding functionality, several tools to assess the functionality of bipolar patients have been used until now, the FAST test being one of them. This test was validated in different populations and at different ages, showing consistent results in BD patients 19,20 . The FAST scores are evaluated through six functional domains: Autonomy; Occupational Functioning; Cognitive Functioning; Financial Issues; Interpersonal Relationships and Leisure Time, where higher scores indicate worse performance, and the total score of the test is calculated by adding the scores of the six subtests (maximum score = 72).…”

Section: Neuropsychological Assessmentmentioning

confidence: 81%

Can we prevent the neuroinflammation and neuroprogression produced by oxidative stress in euthymic bipolar patients, using mood stabilizers?

Lima

Cyrino

Ferreira

et al. 2022

Preprint

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Bipolar Disorder (BD) is associated with systemic toxicity, represented by changes in the biomarkers, associated with mood episodes, leading to neurological damage, which may reflect on cognitive functions and functionality, and the progression of the disease. We aimed to analyze the effect of four biomarkers superoxide dismutase (SOD), catalase (CAT), glutathione peroxidase (GSH-Px) enzymes, and thiobarbituric acid reactive substances (TBA-RS) related to oxidative stress in BD and to correlate them with cognitive functions and functionality. We studied 50 bipolar patients type I/II, in the euthymic phase, which was divided into two subgroups with 25 patients, (≤3 years and ≥10 years of diagnosis, from the first episode of mania), and 25 control patients. To analyze frontal cognitive functions and functionality, we used the tests: Frontal Assessment Battery (FAB) and Functioning Assessment Short Test (FAST), respectively. The FAST test scores results were ≤3 years (20.63±8.21), ≥10 years (27.80±12.50), and control group (9.80±5.94), p<0.001. Changes occurred in all domains. The FAB test scores were ≤3 years (14.64±2.48), ≥10 years (12.44±2.78), and control group (15.84±1.55), p<0.001, and showed lower scores in four domains. The oxidative stress showed an increase in TBA-RS levels: ≤3 years (3.18±1.17), ≥10 years (3.01±1.03) compared to the control group (1.62±0.28), p<0.0001; and in the CAT enzyme activity we found, ≤3 years (8.10±4.18), ≥10 years (9.41±4.95), compared to the control group (3.47±0.77), p<0.0001. Even during the euthymic phase, bipolar patients showed and maintained an increase in CAT activity and lipid peroxidation with significant changes in the FAB and FAST tests in different groups of patients, demonstrating impairment in cognitive functions and functionality since disease onset.

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Section: Neuropsychological Assessmentmentioning

confidence: 81%

Can we prevent the neuroinflammation and neuroprogression produced by oxidative stress in euthymic bipolar patients, using mood stabilizers?

Lima

Cyrino

Ferreira

et al. 2022

Preprint

View full text Add to dashboard Cite

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“…Second, the societal functioning domain of the Functional Assessment Short Test (FAST) was used as additional measurement of social functioning. The FAST was originally developed to assess the main problems in functioning experienced by psychiatric patients, particularly BD patients, and was recently validated for older adults with BD 42 . The FAST is an interviewer‐administered instrument, and is designed to be conducted by a trained clinician.…”

Section: Methodsmentioning

confidence: 99%

“…The FAST was originally developed to assess the main problems in functioning experienced by psychiatric patients, particularly BD patients, and was recently validated for older adults with BD. 42 The FAST is an interviewer-administered instrument, and is designed to be conducted by a trained clinician. The studied time frame refers to the last 15 days before the assessment.…”

Section: Social Functioningmentioning

confidence: 99%

Is social functioning in older age patients with bipolar disorder associated with affective and/or non‐affective cognition?

Paans

Korten

Orhan

et al. 2022

Int J Geriat Psychiatry

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Objectives Previous research showed impairments in non‐affective cognition, affective cognition, and social functioning in adult patients with bipolar disorder (BD). Only 37% of adult BD patients recovers in social functioning, and both aspects of cognition are important constructs of influence. The role of affective cognition in older age bipolar disorder (OABD) patients is still unclear. Therefore, the aim of our study was to examine the separate and combined effects of affective cognition and non‐affective cognition on social functioning. Methods The current study included 60 euthymic patients (aged >60) of the Dutch Older Bipolar Study. Affective cognition was measured by Theory of Mind and Emotion Recognition. Non‐affective cognition was assessed through the measurements of attention, learning and memory, and executive functioning. Social functioning was examined through global social functioning, social participation, and meaningful contacts. The research questions were tested with linear and ordinal regression analyses. Results Results showed a positive association of all non‐affective cognitive domains with global social functioning. Associations between affective cognition and social functioning were non‐significant. Results did show an interaction between non‐affective and affective cognition. Conclusions Associations between non‐affective cognition and social functioning were confirmed, associations between affective cognition and social function were not found. For generalizability, studies with a greater sample size are needed. Conducting additional research about OABD patients and affective cognition is important. It may lead to more insight in impairment and guide tailored treatment that focusses more on all aspects of recovery and the needs of OABD patients.

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“… 7 , 9 , 10 This suggests that model B as currently operationalized may be less suitable for OABD. Future studies should explore other measurements for inter‐episodic functioning for staging with model B in OABD, such as the Functioning Assessment Short Test (FAST‐O 31 ) which has already been validated in OABD patients.…”

Section: Associated Clinical Markersmentioning

confidence: 99%

Illness progression in older‐age bipolar disorder: Exploring the applicability, dispersion, concordance, and associated clinical markers of two staging models for bipolar disorder in an older population

Markt

Beunders

Korten

et al. 2022

Int J Geriat Psychiatry

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Objectives The validity and applicability of two existing staging models reflecting illness progression have been studied in bipolar disorder (BD) in adults, but not in older adult populations. Staging model A is primarily defined by the number and recurrence of mood episodes, model B is defined by the level of inter‐episodic functioning. This study aimed to explore the applicability, dispersion, and concordance of, and associations with clinical markers in these two staging models in older‐age bipolar disorder (OABD). Methods Using cross‐sectional data from the Dutch Older Bipolars study, OABD outpatients (N = 126, ≥50 years) were staged using models A and B. Dispersion over the stages and concordance between the models were assessed. Associations were explored between model stages and clinical markers (familial loading, childhood abuse, illness duration, episode density, treatment resistance, Mini‐Mental State Examination, and composite cognitive score). Results Ninety subjects could be assigned to model A, 111 to model B, 80 cases to both. The majority (61%) had multiple relapses (model A, stage 3C) but were living independently (model B, stage I‐III). Concordance between models was low. For model A, the markers childhood abuse, illness duration, and episode density significantly increased over subsequent stages. Model B was not associated with a significant change in any marker. Conclusions Assigning stages to OABD subjects was possible for both models, with age‐related adjustments for model B. Model B as currently operationalized may be less suitable for OABD or may measure different aspects of illness progression, reflected by its low correspondence with model A and lack of associated clinical markers.

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Reliability and validity of the functioning assessment short test for older adults with bipolar disorder (FAST-O)

Cited by 15 publications

References 22 publications

Can we prevent the neuroinflammation and neuroprogression produced by oxidative stress in euthymic bipolar patients, using mood stabilizers?

Can we prevent the neuroinflammation and neuroprogression produced by oxidative stress in euthymic bipolar patients, using mood stabilizers?

Is social functioning in older age patients with bipolar disorder associated with affective and/or non‐affective cognition?

Illness progression in older‐age bipolar disorder: Exploring the applicability, dispersion, concordance, and associated clinical markers of two staging models for bipolar disorder in an older population

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