Reliability and validity of the Japanese translation of the DN4 Diagnostic Questionnaire in patients with neuropathic pain

Matsuki, Yuka; Sukenaga, Norihiko; Miyagi, Ken; Tsunetoh, Takashi; Mizogami, Maki; Shigemi, Kenji; Maeda, Lynn; Hirose, Munetaka

doi:10.1007/s00540-018-2495-7

Cited by 13 publications

(20 citation statements)

References 22 publications

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“…Items from #1 to #7 of the DN4 questionnaire are answered by interviewing patients, and items from #8 to #10 require examination of patients. DN4 score is the total of these 10 items existing in each patient, and the cut-off value for a diagnosis of neuropathic pain is a score of 4/10 2,3. The reliability, validity, and specificity of the Japanese version of the DN4 diagnostic questionnaire were confirmed in our previous study 3…”

Section: Methodsmentioning

confidence: 69%

“…Neuropathic pain is caused by a lesion or disease of the somatosensory nervous system. Although whether neuropathic pain can or cannot describe some of the underlying mechanisms of painful cranial neuropathies and other facial pains is unresolved, recent reports, using the Douleur Neuropathique 4 (DN4) questionnaire for screening neuropathic pain,2,3 have shown that 69.2% of the patients with trigeminal neuralgia present with neuropathic pain4 and 31% of the patients with burning mouth syndrome present with neuropathic pain 5…”

Section: Introductionmentioning

confidence: 99%

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Neuropathic Characteristics In Patients With Persistent Idiopathic Facial Pain

Sukenaga¹,

Matsuki²,

Maeda³

et al. 2019

JPR

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BackgroundPersistent idiopathic facial pain (PIFP) is a subtype of painful cranial neuropathies and other facial pains. The involvement of neuropathic mechanisms in PIFP, however, remains controversial. Using the Douleur Neuropathique 4 (DN4) questionnaire, the present study examined neuropathic characteristics in patients with PIFP.MethodsThe multi-institutional retrospective study collected the following clinical data from 205 consecutive patients with adult chronic pain: gender, age, BMI, diseases causing chronic pain, disease duration, visual analogue scale score of pain strength, and DN4 score. To compare neuropathic characteristics between PIFP and postherpetic neuralgia (PHN), we selected patients with PIFP (n=19) and patients with PHN (n=33), and performing a case–control study in which each patient with PHN or PIFP was matched by age and gender (n=16 in each group).ResultsDN4 score was significantly lower in the PIFP group than in the PHN group before and after matching. The incidence when DN4 was ≥4 was 10.5% before matching and 12.5% after matching in the PIFP group, both of which were significantly lower than those in the PHN group before and after matching (66.7% and 75.0%).ConclusionTen percent of the PIFP patients likely show neuropathic pain characteristics.

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Section: Methodsmentioning

confidence: 69%

Section: Introductionmentioning

confidence: 99%

Neuropathic Characteristics In Patients With Persistent Idiopathic Facial Pain

Sukenaga¹,

Matsuki²,

Maeda³

et al. 2019

JPR

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“…We used the DN4 questionnaire to discriminate neuropathic pain from other pain states [7,8]. The DN4 questionnaire evaluates 10 items: characteristics of pain (burning (1), painful cold (2), electric shocks (3)), symptoms in the region of pain (tingling (4), pins and needles (5), numbness (6), itching (7)), localized pain (hypoesthesia to touch (8), hypoesthesia to pricking (9)) and pain caused or increased by brushing in the painful area (10).…”

Section: Pain Assessmentsmentioning

confidence: 99%

“…Items #1 to #7 of the DN4 questionnaire are answered by interviewing patients, and items #8 to #10 require examination of patients. DN4 score is a total count of these 10 items for each patient, and the cut-off value for the diagnosis of neuropathic pain is a score of 4/10 [7,8]. DN4 scores were graded as three levels, i.e.…”

Section: Pain Assessmentsmentioning

confidence: 99%

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Association between Neuropathic Pain Characteristics and DNA Methylation of TRPA1 in Human Peripheral Blood

Takenaka¹,

Sukenaga²,

Imasaka³

et al. 2019

Preprint

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Background: Elucidation of epigenetic mechanisms correlating with neuropathic pain in humans is crucial for the prevention and treatment of this treatment-resistant pain state. In the present study, associations between neuropathic pain characteristics and DNA methylation of the transient receptor potential ankyrin 1(TRPA1) gene were evaluated in chronic pain patients and preoperative patients. Methods: Pain and psychological states were prospectively assessed in patients who suffered chronic pain or were scheduled for thoracic surgery. Neuropathic characteristics were assessed using the Douleur Neuropathique 4 (DN4) questionnaire. DNA methylation levels of the CpG island in the TRPA1 gene were examined using whole blood. Results: Forty-eight adult patients were enrolled in this study. Increases in DNA methylation rates at CpG -51 showed positive correlations with increases in the DN4 score both in preoperative and chronic pain patients. Combined methylation rates at CpG -51 also significantly increased together with increase in DN4 scores. Conclusions: Neuropathic pain characteristics are likely associated with methylation rates at the promoter region of the TRPA1 gene in human peripheral blood.

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A Cross-Sectional Web Survey of Satisfaction with Treatment for Pain in Participants with Suspected Diabetic Peripheral Neuropathic Pain in Both Feet

et al. 2021

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Introduction: Diabetic peripheral neuropathic pain (DPNP), a symptom of diabetic polyneuropathy (DPN), is underdiagnosed in people with diabetes. To date, no studies have determined the relationship between diagnosis of DPN and satisfaction with treatment for pain. Additionally, the factors that influence satisfaction with treatment for pain remain unknown. This questionnaire study was conducted to understand satisfaction with treatment for pain among participants with diabetes who experienced bilateral pain or numbness in their feet. Methods: This cross-sectional, observational, web-based questionnaire study for participants with diabetes and suspected DPNP was conducted in Japan. Potential respondents were registered in the INTAGE Disease Panel or the Rakuten Insight Disease Panel. The primary endpoint was the number and percentage of participants who were satisfied with their DPNP treatment. Secondary endpoints included participant opinions regarding treatment-related efficacy, side effects, and economic burden, and factors affecting satisfaction with treatment. Results: The questionnaire was accessed by 7565 potential participants; 777 met the eligibility criteria (final analysis set). Satisfaction with treatment for bilateral foot pain was low (satisfied, 27.9%; neither satisfied nor unsatisfied, 42.2%; unsatisfied, 23.4%; very unsatisfied, 6.4%). Participants were somewhat more satisfied with treatment side effects than with treatment efficacy and economic burden. Satisfaction with treatment mainly differed by improvement in actions in daily life, improvement in quality of life, and communication with doctors. The diagnostic testing rate for DPN was low, and diagnosis was more common in participants who complained of symptoms of pain and numbness (any visit) versus those who did not. Conclusion: Participants with diabetes who experience bilateral foot pain or numbness reported a low level of satisfaction with treatment for pain.

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Reliability and validity of the Japanese translation of the DN4 Diagnostic Questionnaire in patients with neuropathic pain

Abstract: The Japanese version of the DN4 was found to be a helpful tool for discriminating between neuropathic and non-neuropathic pain.

Cited by 13 publications

References 22 publications

<p>Neuropathic Characteristics In Patients With Persistent Idiopathic Facial Pain</p>

<p>Neuropathic Characteristics In Patients With Persistent Idiopathic Facial Pain</p>

Association between Neuropathic Pain Characteristics and DNA Methylation of <em>TRPA1</em> in Human Peripheral Blood

A Cross-Sectional Web Survey of Satisfaction with Treatment for Pain in Participants with Suspected Diabetic Peripheral Neuropathic Pain in Both Feet

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