Transport telematics systems operate under various operational conditions. As elements, which are responsible, among others, for the transport process safety, they should maintain their usability. One of the key problems is to ensure the power supply continuity in the transport telematics systems. In order to provide it, relevant power supply systems are used. The state of unfitness of power supply constitutes a failure in the system operation, the result of which can be downtime in operation of the entire transport telematics system or its part. The article carried out a reliability and operation analysis of the power supply system, which consists of three independent energy sources. The relationships, which allow to specify the probabilities of the system’s staying in the distinguished states, were determined.