Advanced data mining techniques are potential tools for solving civil engineering (CE) problems. This study proposes a novel smart artificial firefly colony algorithm-based support vector regression (SAFCA-SVR) system that integrates firefly algorithm (FA), chaotic maps, adaptive inertia weight, Lévy flight, and least squares support vector regression (LS-SVR). First, adaptive approach and randomization methods are incorporated in FA to construct a novel and highly effective metaheuristic algorithm for global optimization. The enhanced FA is then used to optimize parameters in LS-SVR model. The proposed system is validated by comparing its performance with those of empirical methods and previous works via crossvalidation algorithm and hypothesis test through the realworld engineering cases. Specifically, high-performance concrete, resilient modulus of subgrade soils, and building cooling load are used as case studies. The SAFCA-SVR achieved 8.8%-91.3% better error rates than those of previous works. Analytical results confirm that using the proposed hybrid system significantly improves the accuracy in solving CE problems.