This paper presents a research method of reliability of Microgrid. Firstly, according to different features between the traditional power sources and distributed power supply, the models of power generation reliability evaluation including wind power and solar power are established. Secondly, on the basis of the different operation modes and the importance of the loads, the reliability evaluation index of the sensitive load and nonsensitive load in Microgrid are identified in the condition of their component failure, the external power failure, the micro-source fault as well as in case of lack of micro-source and so on when the Microgrid connected to the great power network or running isolated. Finally, a case of a typical Microgrid system is exhibited. The effectiveness and feasibility of the transactions and optimization model are also overall demonstrated by this simulation.